biomarker - CIRION Central Laboratory

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Electrocheminumiles- cence Immunoassay. C-Reactive Protein (CRP). Immunoturbidimetric. IP-10 (IL-12p70) - 2-plex. xMAP -
LIST OF BIOMARKERS BIOMARKERS

ANALYTICAL METHODS

BIOMARKERS

ANALYTICAL METHODS

Anemia Erythropoietin (EPO)

Chemiluminescent Immunoassay

Reticulocytes

Automated Hematology

Ferritin

Chemiluminescent Immunoassay

Soluble Transferrin Receptor (sTrR)

Immunoturbidimetric

Folic Acid (folates)

Chemiluminescent Immunoassay

Transferrin

Immunoturbidimetric

Hemoglobin

Colorimetric

Unsaturated Iron Binding Capacity (UIBC)

Colorimetric

Iron

Colorimetric

Vitamin B12

Chemiluminescent Immunoassay

Iron Saturation

Autoimmune Disease Anti-Double Stranded DNA Ab (dsDNA)

ELISA

Anti-Sjogren Syndrome Ab (SS-B/La)

ELISA

Anti-Nuclear Ab (ANA)

ELISA

Anti-Ribonucleo Protein Ab (RNP)

ELISA

Anti-Smooth Muscle Ab (ASMA)

ELISA

Anti-Mitochondrial Ab (AMA)

ELISA

Anti-Sjogren Syndrome Ab (SS-A/Ro)

ELISA

Anti-Thyroid Peroxidase Ab (TPO)

ELISA

Bone Diseases Alkaline Phosphatase (ALP)

Colorimetric

Osteocalcin

RIA

Aminoterminal Propeptide Type 1 Collagen (PINP)

RIA

Parathyroid Hormone (PTH)

Immunochemistry

Bone Specific Alkaline Phosphatase (BSAP)

ELISA

Tartrate Resistant Acid Phosphatase-5b (TRACP5b)

ELISA

Calcium (Ca)

Colorimetric

Vitamin D, 1,25 Dihydroxy

ELISA

C-Terminal Type I Collagen Telopeptide (CTx)

ELISA

Vitamin D, 25 Hydroxy

ELISA

N-terminal Type I Collagen Telopeptide (NTx)

ELISA

Endothelin-1

ELISA

Cardiac Markers Apolipoprotein E (Apo E)

Nephelometric

Brain Natriuretic Peptide (BNP)

ELISA

LDH

Colorimetric

CK

Colorimetric

Potassium

Automated Polarization

CKMB

Immunochemistry

Pro-B-type Natriuretic Peptide (Pro-BNP)

ELISA

C-Reactive Protein (CRP)

Immunoturbidimetric

Troponin I

Immunochemistry

CRPhs (ultrasensitive)

Immunoturbidimetric

Diabetes C-Peptide

ELISA/RIA

HbA1c

Immunoturbidimetric/ HPLC

Cholesteryl Ester Transfer Protein (CETP)

ELISA

IA-2 Antibody

ELISA

Free Fatty Acids (FFA)

Immunoturbidimetric

Insulin

Immunochemistry/RIA

Fructosamine

Immunoturbidimetric

Insulin Growth Factor (IGF-1)

ELISA

Glucagon

RIA

Microalbumin

Immunoturbidimetric

Glucose

Colorimetric

Proinsulin

ELISA

Glutamate Decarboxylase-65 (GAD-65 ) Antibody

ELISA

BIOMARKERS

ANALYTICAL METHODS

BIOMARKERS

ANALYTICAL METHODS

Endocrinology Alpha-Foetoprotein

Chemiluminescent Immunoassay

Growth Hormone

ELISA

Adrenal Corticotrophic Hormone (ACTH)

ELISA

Growth Releasing Factor (GRF)

ELISA

Corticosterone

RIA

Prolactin

ELISA

Cortisol

Chemiluminescent Immunoassay

Testosterone

Chemiluminescent Immunoassay

Follicle Stimulating Hormone (FSH)

Chemiluminescent Immunoassay

ELISA

Lipase

Enzymatic

Anti HBs

Immunometric

Hepatitis B Viral Load (quantitative)

RT-PCR

Anti-HBc

Immunometric

Hepatitis C Genotype

PCR

Anti-Hbe

Immunometric

Hepatitis C Viral Load (qualitative)

PCR

Anti-HCV

Immunometric

Hepatitis C Viral Load (quantitative)

RT-PCR

Anti-HIV I/II

Immunometric

HIV Viral Load (quantitative)

RT-PCR

Chlamydia Trachomalis

PCR

Mononucleosis

Agglutination - manual

Cytomegalovirus (CMV)

PCR

Mycobacterium Tuberculosis

PCR

HBsAg

Immunometric

Neissera Gonorrhoea

PCR

CD Cell Markers*

Flow Cytometry

Immunoglobulins (IgA, IgG, IgM)

Immunoturbidimetric

Clusterin (Apolipoprotein J)

ELISA

Intra-Cellular Adhesion Molecule-1 (ICAM-1) - 2plex

Electrocheminumilescence Immunoassay

C-Reactive Protein (CRP)

Immunoturbidimetric

IP-10 (IL-12p70) - 2-plex

xMAP - Luminex

Gastroenterology Gastrine

Infectious Diseases

Inflammation/Immunity

CRPhs (ultrasensitive)

Immunoturbidimetric

ISG15 gene expression

PCR

Endothelin-1

ELISA

ISG56 gene expression

PCR

Fibrinogen

Coagulometry

Macrophage Inflammatory Protein (MIP 1Į )

xMAP - Luminex

Glucose-6-Phosphate Dehydrogenase (G-6-PDH)

Colorimetric

Macrophage Inflammatory Protein (MIP 1ȕ )

xMAP - Luminex

HLA-A

PCR

Matrix Metalloproteinase-2 (MMP-2)

xMAP - Luminex

HLA-B

PCR

Matrix Metalloproteinase-9 (MMP-9)

xMAP - Luminex

HLA-C

PCR

Monokine Induced by IFNȖ (MIG/CXCL9)

ELISA

IFN-alpha

ELISA

Neopterin

ELISA

IFNȖ (IL-2,IL-4-IL-10) - 4-plex

xMAP-Luminex

OAS1 gene expression

PCR

IL-10

ELISA

OAS2 gene expression

PCR

IL-10 (IL-2,IL-4,IFNȖ) - 4-plex

xMAP - Luminex

OAS3 gene expression

PCR

IL-1ȕ

ELISA

Rantes/CCL5

xMAP - Luminex

IL-2 (IL-4,IL-10-IFNȖ) - 4-plex

xMAP- Luminex

Serum Amyloid Protein (SAA)

Nephelometric

IL-4 (IL-2,IL-10,IFNȖ) - 4-plex

xMAP- Luminex

Tumor Growth Factor (TGF-ȕ1)

ELISA

IL-6

Electrocheminumilescence Immunoassay/ELISA

Tumor Necrosis Factor (TNFĮ)

Electrocheminumilescence Immunoassay/ ELISA

IL-8

xMAP-Luminex/ELISA

Vascular Adhesion Molecule-1 (VCAM-1)- 2 plex

Electrocheminumilescence Immunoassay

BIOMARKERS

ANALYTICAL METHODS

BIOMARKERS

ANALYTICAL METHODS

Lipid Metabolism Apolipoprotein AI (Apo AI)

Nephelometric

Cholesterol

Colorimetric

Apolipoprotein AII (Apo AII)

Nephelometric

HDL-Cholesterol

Immunoturbidimetric

Apolipoprotein B-100 (Apo B)

Immunoturbidimetric

LDL-Cholesterol (Direct)

Enzymatic

Apolipoprotein B48 (Apo B48)

ELISA

Lecithin Cholesterol Acyltransferase (LCAT)

ELISA

Apolipoprotein CII (Apo CII)

Immunoturbidimetric

Paraxonase (PON1)

UV/Colorimetric

Apolipoprotein CIII (Apo CIII)

Immunoturbidimetric

Phosphatidyl Inositol Glycan F (PIGF)

ELISA

Apolipoprotein E (Apo E)

Nephelometric

Triglycerides

Colorimetric

Alpha-GST

ELISA

Glomerular Filtration Rate

Beta-2-Microglobulin (serum)

Immunoturbidimetric

Microalbumin

Immunoturbidimetric

Beta-2-Microglobulin (urine)

ELISA

N-Acetylȕ-Glucosaminidase (NAG)

Enzymatic

Collagen Type IV

ELISA

Pi-GST

ELISA

Creatinine

Colorimetric

Nephrology

Oncology Bcl-2/IGH

PCR

Placenta Growth Factor (PlGF)

ELISA

Carbohydrate Antigen 19-9 (CA19-9)

Immunochemistry

Prostate Specific Antigen (PSA)

Chemiluminescent Immunoassay

Carcinogenic Embryonic Antigen (CEA)

Chemiluminescent Immunoassay

Vascular Endothelial Growth Factor (VEGF)

ELISA

Fibroblast Growth Factor (FGFb)

ELISA

Thyroid Markers Anti-Thyroid Peroxidase Ab (TPO)

ELISA

Thyroid Stimulating Hormone (TSH)

Immunochemistry

Anti-Thyroglobulin Ab

ELISA

Total Thyroxin (T4)

Immunochemistry

Free Thyroxin (FT4)

Immunochemistry

Total Triiodothyronin (T3)

Immunochemistry

Free Triiodothyronin (FT3)

Immunochemistry

TSH Receptor Ab

RIA

Thyroglobulin

ELISA

*For a complete list of CD Cell Markers, please contact us at: [email protected]

The integration of each of our services provides the most accurate results for diagnosis, prognosis and patient monitoring. For more information regarding biomarkers, other Research and Development services and Central Laboratory services, please contact: [email protected]

CIRION Clinical Trial Services Inc. 2121 Berlier Street, Laval, QC H7L 3M9 - Tel: 1-866-688-2474 – Fax: 1-450-902-3060

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