shown using data from four longitudinal cohorts from childhood to adulthood that adult risk of ... cardiovascular system
DOI: 10.1161/CIRCULATIONAHA.111.085977
Childhood Physical, Environmental and Genetic Predictors of Adult Hypertension: The Cardiovascular Risk in Young Finns Study
Running title: Juhola et al; Childhood predictors of adult hypertension
Downloaded from http://circ.ahajournals.org/ by guest on November 13, 2017
Jonna Juhola, MD1; Mervi Oikonen, PhD1; Costan G. Magnussen, PhD1,4; Vera Mikkilä, PhD5; Niina Siitonen, PhD6; Eero Jokinen, MD, PhD7; Tomi Laitinen, MD, PhD8; Peter Würtz, PhD9; Samuel S. Gidding, MD10; Leena Taittonen, MD, PhD11; Ilkka Seppälä, MSc12; Antti Jula, MD, PhD13; Mika Kähönen, MD, PhD14; Nina Hutri-Kähönen, MD15, PhD; Terho Lehtimäki, MD, PhD12; Jorma S.A. Viikari, MD, PhD3; Markus Juonala, MD, PhD3; Olli T. Raitakari, MD, PhD1,2 1
Rsrch Ctr of Applied and Preventive Cardiovascular Medicine; 2Dept of Clinical Physiology; Phyysiiol olo ogy; 3De ogy; Dept pt ooff 4 Medicine, Univ of Turku and Turku Univ Hosp, Turku, Finland; Menzies Research Inst Tasmania, Univ of Tasmania, Hobart, Australia; 5Div of Nutrition, Dept of Food and Environmental Sciences, Univ of Helsinki, Helsinki; Hels He lsin ls inki in ki,, He ki Hels l in nki ki;; 6Dept of Clinical Nutrition and d Food Foo ood and Health Rsrch h Ct Ctr Ctr, r, Inst of Public Health & Clinical Nutrition, Eastern Finland, Kuopio; Cli Cl inicall N inic ut tion utriti on,, Un Univ iv ooff East ster e n Fi F n an nl nd, d Kuo uopi pio o; 7Chil Children’s ldr dren en’s H Hos, os,, He os Helsinki els lsin inki U Univ niiv Hosp Hosp, p, He Helsinki; 8 Dept Dep De pt of Clinical Clin nic i al Physiology, Phy h si siol olog ogy, og y U y, Univ niv ni v of E Eastern a te as tern rn nF Finland inla in landd & K Kuopio uopi uo pio pi o Un Uni Univ iv H iv Hosp, osp os p, K p, Kuopio; uoopi pio; o; 9In Inst s ffor st or M or Molecular olec ol eccul u ar M edi d cine Finland, Finland nd, Univ Univ v of of Helsinki, Hellsiinki He ink , Helsinki, He sin Hels ink ki, Finland; Fin nland d; 10Ne Medicine Nemours Nemo mou mo urss Ca Cardiac ard diac C Ctr, trr, Alfred Alfr lfred red I. I du duPont uPontt Ho uPo Hosp sp for Children, Wilmington, DE; C Chil hil ilddren, Wi Wilm lmin lm ngtton, DE E; 11De Dept p of Pe pt P Pediatrics, diaatricss, U Univ niv v ooff Ou Oul Oulu, lu, Ou lu, Oulu & Deptt ooff P Pediatrics, edia ed iatr t iccs, V Vaasa aassa Cen Central enttral en 12 14 15 Hosp, Hosp Ho sp,, Va sp Vaas Vaasa; asa; as a; De Dept ptt ooff Cl Clinical lin inic i all C Chemistry, hemi he mist mi stry ry y, Fi Fim Fimlab mlab ab L Laboratories; abor abor orat ator at orrie ies; s De s; Dept pt of of Clinical Clin in nic ical al Physiology; Phy hysi sio si olog olog ogy; y; Dept Deptt ooff Pediatrics, Pe edi diat atricss, Un U Univ iv off Ta Tamp Tampere mperre & Ta Tamp Tampere mpere Univ Univ Hosp, Hossp, Tampere, Tam mpe pere re,, Finland; Finl Fi nlan nd; 133De Dept pt of of He Heal Health alth h aand nd Fun Functional unct ctio i na nall Capacity, National Health Welfare, Turku Capa Ca paci pa c ty y, Na Nati t onnal IInst ti nstt fo ns forr He H a th aand al nd W elfa el faree, Tu fa Turk rku rk u
Address for Correspondence: Jonna Juhola, MD Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku Kiinamyllynkatu 10 FI-20520 Turku, Finland Tel: +358-2-333 7555 Fax: +358-2-333 7270 E-mail:
[email protected] Journal Subject Codes: [8] Epidemiology; [193] Clinical studies; [121] Primary prevention; [135] Risk Factors; [89] Genetics of cardiovascular disease 1
DOI: 10.1161/CIRCULATIONAHA.111.085977
Abstract:
Background - Hypertension is a major modifiable cardiovascular risk factor. The present longitudinal study aimed to examine the best combination of childhood physical and environmental factors to predict adult hypertension and furthermore, whether newly identified genetic variants for blood pressure (BP) increase the prediction of adult hypertension. Methods and Results - Study cohort included 2,625 individuals from the Cardiovascular Risk in Downloaded from http://circ.ahajournals.org/ by guest on November 13, 2017
Young Finns Study who were followed up for 21-27 years since baseline (1980, age 3-18 years). In addition to dietary factors and biomarkers related to blood pressure, we examined whether a genetic risk score (GRS) based on 29 newly identified single nucleotide polymo polymorphisms (SNPs) orp phi hism smss (S sm (SNP NPs) NP s enhances the prediction of adult hypertension. Hypertension in adulthood was defined as systolic BP 130mmHg condition. 13 130m 0mmH 0m mHg or ddiastolic mH iastolic BP 85mmHg or medication meedi dica c tion for the cond dit itio ion. Independent io childhood BP ch hilldhood risk riiskk ffactors actors act tors ffor or aadult dult du lt hhypertension yper yp erte er t nsio te nsio on in iincluded c ud cl uded iindividual’s ndiv nd ivid iv idua id uaal’ss ow ownn B P ((P
