7 Nov 2014 - Academy Sciences, Science, Respiratory Cell and Molecular Biology, Veterinary Microbiology,. Viral Immunolo
CURRICULUM VITAE
Kenneth Laurence Tyler, M.D. Reuler-Lewin Family Professor & Chair, Department of Neurology University of Colorado School of Medicine Neurology Mail Stop B-182 Research Complex -2 12700 East 19th Avenue Aurora, Co 80045
Education: The Noble and Greenough School, Dedham, MA Summa Cum Laude A.B., Harvard University, Cambridge, MA Magna Cum Laude M.D., The Johns Hopkins University School of Medicine, Baltimore, MD
Internship and Residencies: Intern and Resident, Internal Medicine, Peter Bent Brigham Hospital, Boston, MA Neurology Resident, Massachusetts General Hospital, Boston, MA Chief Resident, Neurology, Massachusetts General Hospital, Boston, MA Research Fellowships: Research Fellow, Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA Other Training: Program for Chiefs of Clinical Services, Harvard School of Public Health, Boston, MA
Selected Academic Appointments:
1
1986-1991
Assistant Professor of Neurology (Neuroscience), Harvard Medical School
1991-1995
Associate Professor of Neurology Associate Professor of Medicine, Microbiology, Immunology University of Colorado Health Sciences Center
1995-
Professor of Neurology (tenured) Professor of Medicine, Microbiology, Immunology University of Colorado Health Sciences Center
1997-2000
Vice-Chairman, Dept. of Neurology University of Colorado Health Sciences Center
1998-1999
Acting Chair, Dept. of Neurology University of Colorado Health Sciences Center
2001-
Reuler-Lewin Family Professor of Neurology
2009-
Chair, Department of Neurology, University of Colorado School of Medicine
2010-
Co-Director, University of Colorado School of Medicine Center for Neuroscience (CNS)
Selected Hospital Positions: 1986-1991
Assistant Neurologist, Massachusetts General Hospital
1991-
Physician, Neurology Service, VA Medical Center, Denver, CO
1995-2009
Chief, Neurology Service, VA Medical Center, Denver CO
2009-present
Chair, Neurology University of Colorado Hospital (UCH) Member, Medical Board, University of Colorado Hospital (UCH) Member, Board of Directors, University Physicians Inc. (UPI)
Other Professional Positions: Member, University of Colorado Cancer Center Graduate Faculty, Dept. Immunology-Microbiology, Univ. Colorado Health Sciences Center Faculty, Medical Scientist Training Program (MSTP) Univ. Colorado Health Sciences Center Faculty, Biomedical Sciences Program Univ. Colorado Health Sciences Center
2
Member, Neuroscience Program and Center Univ. Colorado Health Sciences Center
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Selected Honors & Awards: Phi Beta Kappa Alpha Omega Alpha Honor Medical Society S. Weir Mitchell Award, American Academy of Neurology Muscular Dystrophy Association Research Fellowship Physician-Scientist Award, National Institute of Allergy and Infectious Disease William F. Milton Fund Research Fellow, Harvard University Alfred P. Sloan Foundation Research Fellow Science College, Concordia University, Public Lecture Series, Montreal, Canada Rhea & Louis Boshes Visiting Professor Dept. Neurology, Northwestern University School of Medicine Member, American Society for Clinical Investigation (ASCI) Who’s Who in America® (2000 et seq, latest 2011, Marquis Who’s Who) Lawrence McHenry Jr. Award, American Academy of Neurology Best Doctors in America, 2001-current (http://www.bestdoctors.com) 5th Landau Lecturer, Washington University School of Medicine, St. Louis, MO. Julius Brendel Trust Visiting Professor, Auckland, New Zealand Inaugural Walter Friedlander Lecturer, University of Nebraska School of Medicine, Omaha, NE WT Connell Memorial Professor, Queens University, Ontario, Canada Chair, National Institute’s of Health (NIH) Clinical Neuroimmunology & Brain Tumors Study Section (CNBT) (thru June 2008) America’s Top Physicians, Guide to America’s Top Physicians, Consumers Research Council of America, (http://www.consumersresearchcncl.org) Fellow, American Association for the Advancement of Science Member, Association American Physicians (AAP)
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5
25th Andrew Mark Lippard Lecturer, Columbia University School of Medicine Keynote Speaker, University of Utah Baringer Resident Graduation Symposium Salt Lake City, Utah US News World Report, Top Doctors (neurologists) Fellow, American Academy of Microbiology 40th Robert Aird Visiting Professor, University of California San Francisco Elected, Henry Kunkel Society, Rockefeller University
Selected Memberships, Offices and Committee Assignments in Professional Societies: American College of Physicians (ACP), Fellow American Federation for Medical Research (AFMR) American Academy of Neurology (AAN), Fellow Director, (AAN Board of Directors) 2003-2007 American Society for Neurological Investigation; American Society for Microbiology (ASM) American Society for Virology (ASV) Society for Experimental Neuropathology Councilor, 1996-1999 Society for Neuroscience American Neurological Association (ANA), Fellow Treasurer Board of Directors (Council)(2012-) Scientific Program Committee (2006-2009) Long Range Planning Committee (1999-2000)(2004-2005) Colorado Society of Clinical Neurologists Secretary Treasurer, 1993-1995 Association of VA Neurologists Councilor, 1996-1998 American Society for Clinical Investigation
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International Society for Neurovirology Infectious Disease Society of America (IDSA), Fellow American Association for the Advancement of Science (AAAS), Fellow Association of American Physicians (AAP) International Advisory Committee, XVth International Congress of Virology Fellow, American Academy of Microbiology Steering Committee, West Nile Virus Colloquium (2013) Association of University Professors of Neurology (AUPN), Executive Council
Selected Active & Prior Major Committee Assignments and Study Sections: Institute of Medicine (IOM), National Academy of Sciences Research Briefing Panel on the Molecular Biology of Microbe-Host Interaction (consultant) National Multiple Sclerosis Society, Scientific Advisory Committee (fellowships) Ad Hoc reviewer: Visual Sciences C Study Section, NIH Ad Hoc reviewer: NINDS NSP-B (Program Projects) Committee, NIH Ad Hoc reviewer: Dept. Veterans Affairs Merit Review Board Special reviewer: Experimental Virology (EVR) Study Section, NIH Member, Medical Advisory Research Group (MRAG) (Neurological and Sensory Disorders), Dept. of Veterans Affairs NIAID Division of Microbiology & Infectious Diseases, Neurotropic Viruses Blue Ribbon Panel Board Examiner, American Board of Psychiatry and Neurology (Neurology) External Reviewer, Institut Pasteur, Structures de Recherche (Unite de Biologie Moleculaire de l’Expression Genique) Paris, France NIH/NIAID Neurology Advisory Group for West Nile Virus External Reviewer, Institut Pasteur, L’Evaluation Scientifique, Paris. France Temporary Member, Experimental Virology (EVR) Study Section, NIH
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Member, Special Emphasis Panel, ZRG1 (Neurovirology), Experimental Virology (EVR) Study Section, NIH Regular Member, Clinical Neuroimmunology and Brain Tumors Study Section (CNBT, Formerly BDCN-4), Study Section, NIH. Chair, NIH CNBT (Clinical Neuroimmunology & Brain Tumors) Study Section Member, NIH Special Emphasis Panel, ZRG1 IDM-R 02 (Pathogenic Viruses) Member, NIH Special Emphasis Panel, ZRG1 IDM-B (02) (Viral Pathogens)
Member, NIH Special Emphasis Panel, ZAG1 ZIJ-2 (05)(Aging and Disease) Reviewer, NIH Special Emphasis Panel, ZRG1 IMM-E(58)R (Immunologic Sciences) Reviewer, NIH Special Emphasis Panel, ZRG1 BDCN-Y (02) M, (Neurodegenerative Disorders) Board of Scientific Counselors, NINDS (Ad Hoc Reviewer) Welcome Trust (London, UK), External Peer Reviewer (Senior Investigator Awards) Temporary Member, VIRA (Virology A) Study Section, NIH Member, ZRG1 BDCN-L(52)R, US-India Bilateral Brain Research Collaborative Partnership Special Emphasis Panel Temporary Member, NURC (Neurosciences) Study Section, Dept. Veterans Affairs Alpha Omega Alpha Student Research Fellowship Reviewer Member, ZA/1LGR-M(S1), NIAID Clinical Trials Planning and Implementation Grants Special Emphasis Panel NIH Center for Scientific Review (CSR) Advisory Council (External Review Committee for Evaluation of Infectious Diseases and Microbiology (IDM) Integrated Review Group Study Sections) Reviewer, Efficacy and Mechanism Evaluation Program, Medical Research Council (MRC). National Institute for Health Research/National Health Service, United Kingdom Member (Temporary), NINDS Neurological Sciences and Disorders C (NSD C) Study Section Center for Zoonotic and Emerging Infectious Diseases, Montana State University, pilot project reviewer (COBRE-NIH NIGMS Centers for Biomedical Research Excellence)
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Member, ZAI1-JKB-M-M1, NIAID Clinical Trials Planning Special Emphasis Panel
Licensure and Board Certification: National Board of Medical Examiners Massachusetts License Board of Registration and Discipline in Medicine American Board of Internal Medicine American Board of Psychiatry and Neurology Colorado License Colorado State Board of Medical Examiners
Selected Review and Referee Work: Editorial Boards: (COMPLETED) Journal of the Neurological Sciences (Associate Editor) Journal of the History of Neuroscience Journal of Virology European Journal of Neurology Neurology Current Opinion in Neurology (Editor: Inflammatory Diseases & Infection, vol. 28(3), June 2015)
(ACTIVE) Microbial Pathogenesis Journal of Neurovirology (Senior Associate Editor, 2006-) Archives of Neurology Apoptosis
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Experimental Neurology Journal of Infectious Disease Virology Annals of Neurology Journal of Cell Death Neurology Today (Associate Editor)
Ad Hoc reviewer for the following additional journals: Annals Internal Medicine, Archives of Physical Medicine & Rehabilitation, BMC Infectious Diseases, BMC Veterinary Research, Brain, Brain Research, Cellular Microbiology, Clinical Infectious Diseases, Diabetologia, Epilepsia, European Journal of Clinical Microbiology & Infectious Diseases, Herpes Journal, Infections in Medicine, JAMA, Journal of Clinical Investigation, Journal of Clinical Virology, Journal of Experimental Medicine, Journal of Neuroimmunology, Journal of the Neurological Sciences, Journal of Neurology Neurosurgery & Psychiatry, Journal of Neuropathology & Experimental Neurology, Laboratory Animal Science, Lancet Infectious Disease, Lancet Neurology, Muscle & Nerve, Nature Clinical Practice in Neurology, Nature Immunology Reviews, Nature Medicine, Neuropsychologia, New England Journal of Medicine, Pediatric Infectious Disease, PLoS Pathogens, Proceedings National Academy Sciences, Science, Respiratory Cell and Molecular Biology, Veterinary Microbiology, Viral Immunology, Virus Research
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Selected Invited Extramural Lectures, Grand Rounds, Seminars, Symposia (2005 on): International 2006
Neurology Grand Rounds, Neurolgische Klinik und Poliklinik, Universitatsklinikum Wurzburg, Germany
2006
Seminar, Departement de Biologie Cellulaire et Morphologie (DBCM) and the Departement de Physiologie, Universite de Lausanne, Switzerland
2008
Chair, Symposium on Reo, rota, and orbiviruses. XIVth International Congress of Virology, Istanbul, Turkey, Aug 10-15, 2008
2008
Speaker, Infectious diseases of the nervous system: pathogenesis and worldwide impact (conference), Pasteur Institute, Paris
2009
Speaker, 6th Hong Kong University Pasteur Institute -Virology Course, Hong Kong University-Pasteur Research Center, Hong Kong, China
2010
Plenary Session Discussant, Contemporary Clinical Issues & Case Studies Plenary Session, 61st Annual Meeting, American Academy of Neurology, Toronto, Canada
2012
Keynote Speaker, Emerging Zoonotic Viral Infections of the Nervous System Symposium, Depart. Medical Microbiology, University of Manitoba, Winnipeg, Canada
2012
Plenary Speaker, 11th International Symposium on Double-Stranded RNA viruses, San Juan, PR
2012
Plenary Speaker, 11th International Symposium on Double-stranded RNA Viruses, San Juan, Puerto Rico
National: 2005
Neurology Grand Rounds, NYU School of Medicine, NY, NY
2005
Neurology Grand Rounds, Cornell University School of Medicine, NY, NY
2005
Seminar Speaker. Pathogenesis Affinity Group, The Scripps Research Institute, La Jolla, CA (How a virus kills a cell).
2005
New York Academy of Sciences. Neuroimmunology Discussion Group Meeting.
2006
Neurology Grand Rounds, Department of Neurology, Albert Einstein University School of Medicine, NY, NY.
2006
Neurology Grand Rounds, Department of Neurology, Columbia University
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School of Medicine, NY, NY. 2006
Neurology Grand Rounds, Department of Neurology & Neuroscience, University of California at San Diego
2007
Neurology Grand Rounds, New York University, NYC
2007
National Diabetes Trial Network (Diabetes TrialNet) Steering Committee
2007
40th Annual Winter Conference on Brain Research, Snowmass Village, CO
2007
B-Cell Summit: Targeting B Cells in the Treatment of Immune-Mediated Disease, Newport Beach, CA (Genentech/Biogen Idec)
2007
Neurology Grand Rounds, Massachusetts General Hospital, Harvard Medical School.
2007
Speaker, Presidential Plenary Symposium, American Neurological Association 132nd Annual Meeting, Washington DC
2008
University of Illinois College of Medicine at Peoria. Seminar. Department of Cancer Biology and Pharmacology.
2008
Neurology Grand Rounds, Yale University School of Medicine
2009
Symposium, Genentech, Immunology, Tissue Growth & Repair (ITGR) Group, San Francisco, CA
2009
Neurology Grand Rounds, University of Pittsburgh School of Medicine
2009
Special Lecturer & Workshop Chair (Signal Transduction & Cellular/viral Gene Expression), 9th International Symposium on Neurovirology, Miami Beach, FL
2009
Neurology Grand Rounds, Weil Medical College, Cornell University
2009
Keynote Speaker, 27th Annual Conference on Pediatric Infectious Diseases, Vail, CO
2010
Neurology Grand Rounds, University of Kentucky College of Medicine
2010
Department of Biological Sciences Seminar, University of Denver
2010
25th Andrew Mark Lippard Lecturer, Columbia University School of Medicine
2010
Neurology Grand Rounds, NIH National Institute of Neurological Diseases & Stroke (NINDS)
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2011
Keystone Symposium, Genetics, immunology and repair in MS (Macklin W, Giovannoni G, Hauser S, Organizers)
2011
Neurology Grand Rounds, Johns Hopkins University School of Medicine
2011
Keynote Speaker, J. Richard Baringer Neurology Resident Graduation Symposium, Department of Neurology, University of Utah School of Medicine
2011
Speaker, Seminar Series (CNS Infections), Hope Center for Neurological Disorders, Mini-symposium on neurovirology, Washington University St. Louis.
2011
Seminar speaker, Department of Immunology & Infectious Diseases, Montana State University
2012
Keynote Speaker, 7th Annual University of Alaska Biomedical Research Conference, Fairbanks, AK
2012
40th Robert B. Aird Visiting Professor, Neurology Department, University of California, San Francisco (UCSF)(scheduled, Sept., 2012)
2012
Neurology Grand Rounds, University of Maryland
2013
West Nile Virus, American Academy of Microbiology Colloquium, Denver, CO
2013
American Society for Microbiology (ASM) Conference for Undergraduate Educators, “Outbreak: West Nile virus”.
2014
Speaker & Panelist, Annual Meeting of the Association of Health Care Journalists, “What promise does the BRAIN initiative hold?” (Scott Hensley, NPR, moderator)
2014
22nd Annual Meeting, Henry Kunkel Society, Rockefeller University, invited speaker
2014
Neurohospitalist Society, 2nd Annual Meeting, Denver, CO invited speaker, “Neurovirology”
2015
67th Annual Meeting, American Academy of Neurology, Washington DC. Integrated Session Speaker (I7); Global Burden of Neurological Infections. West Nile Virus Neuroinvasive Disease.
2015
31st Clinical Virology Symposium, American Society for Microbiology (ASM), Daytona Beach, FL. Diagnostic Strategies for CNS Viral infections.
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2015
Weill Cornell School of Medicine, Neurology Grand Rounds
2015
Neurology Grand Rounds, University of Washington, Seattle (pending)
2016
Neurology Grand Rounds, University of Rochester, Rochester NY (invited)
Selected Graduate and Post-graduate Courses (2005 on): 2005
Co-Director, Course on the Neurological Complications of Emerging Infections and Bioterrorism (with J. Berger), 57th Annual Meeting American Academy of Neurology, Miami Beach, FL
2006
Faculty, Course on Infections of the Nervous System (Viral encephalitis) 58th Annual Meeting American Academy of Neurology, San Diego, CA.
2006
Faculty, Course on Neurological Complications of Emerging Infections and Bioterrorism, 58th Annual Meeting American Academy of Neurology, San Diego, CA.
2006
Faculty, Teaching Course on Current Treatments in Neurology (Herpes virus infection of the nervous system), 16th Meeting of the European Neurological Society, Lausanne Switzerland
2006
Chair, Symposium on Novel Neurotherapeutic Approaches to Neurological Diseases. American Neurological Association (ANA) 131st Annual Meeting, Chicago, IL
2006
Co-Director, Workshop on MS, JC Virus and PML. American Neurological Association (ANA) 131st Annual Meeting, Chicago, IL
2007
Faculty, Neurological Complications of Emerging Infections and Bioterrorism, 59th Annual Meeting, American Academy of Neurology, Boston, MA
2007
Chair, Derek Denny Brown Symposium, American Neurological Association (ANA) 132nd Annual Meeting, Washington, DC
2008
Faculty, Course on Infections in the Nervous System 60th Annual Meeting American Academy of Neurology, Chicago, IL
2009
Faculty, 6th Hong Kong University-Pasteur Research Centre Virology Course, Hong Kong, China (July 7-24, 2009)
2009
Faculty, 27th Annual Conference on Pediatric Infectious Diseases, Vail, CO
2010
Faculty, Course on Therapy in Neurology, 61st Annual Meeting American Academy of Neurology, Toronto, Canada
2011
Faculty, Course on Infections of the Nervous System, 61st Annual Meeting
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American Academy of Neurology, Honolulu, Hawaii 2015
Faculty, Infectious, Paraneoplastic, Autoimmune? (C28), 67th Annual Meeting, American Academy of Neurology, Washington, DC. Diagnosis and Management of Acute Viral Encephalitis.
2015
Faculty, Neurology Update I (C37), 67th Annual Meeting, American Academy of Neurology, Washington DC. Update in Acute Viral Encephalitis.
Grant Support I. Active Primary Research Awards as PI NIH 1R01 NS076512 Kenneth L. Tyler, P.I. Cellular genes and signaling pathways as therapeutic targets for viral CNS disease 09/15/2011-08/31/2015
Department of Veterans Affairs Kenneth L. Tyler, P.I. Merit Review Grant 1 01 BX000963 Mechanisms and treatment of viral myelitis and spinal motor neuron injury 10/1/11-9/30/15 NIH 5R33 AI101064 Kenneth L. Tyler, P.I. Identification and evaluation of novel therapeutic targets for virus-induced neurological disease 07/1/2014-6/30/2017
II. Training Grants NIH-2T32 NS007321 Neurovirology-Molecular Biology training grant NIH/NINCDS 7/1/10 - 6/30/15 Role: Executive Committee, Faculty
Donald H. Gilden, P.I.
NIH 5-T32-AI052055 Molecular Pathogenesis of Infectious Disease 8/1/13-7/31/18 Role: Associate Director
Andres Vazquez-Torres,
IV. Selected Completed Awards as PI NIH 1 R01 NS051403 Mechanisms of virus-induced apoptosis in neurons and CNS 02/07/2006-12/31/2010
NIH/NINDS 1R01 NS050138
Kenneth L. Tyler, P.I.
Kenneth L. Tyler, P.I.
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Mechanisms of apoptosis in the central nervous system 1/1/2005-12/31/2010
DAMD17-98-1-8614 US Army Medical Research & Material Command (Neurotoxin Exposure Research treatment Program) Mechanisms of virus-induced neural cell death 7/1/98-3/14/05
Kenneth L. Tyler, P.I.
Department of Veterans Affairs Kenneth L. Tyler, P.I. Research Enhancement Award Program (REAP) Mechanisms & prevention of cell death in neurodegenerative diseases 4/1/99-3/31/05
Department of Veterans Affairs Merit Review Grant Mechanisms of virus-induced apoptosis 5/1/01-4/31/06 V. Selected Completed Awards as Mentor NIH NINDS 1F30NS071630 Individual Predoctoral Fellowship Award Role of Daxx in reovirus-induced apoptosis 09/01/2010-8/30/2014
Kenneth L. Tyler, P.I.
Sponsor/Mentor: Kenneth L. Tyler Recipient/trainee: Kalen Dionne
NIH K08 1K08AI076518 Sponsor/Mentor: Kenneth L. Tyler Mentored Clinician-Scientist Award Recipient/Trainee: Dr. David Beckham Mechanisms of Apoptosis in virus-infected neurons and brain 10/1/08-9/30/13
NIH NINDS 1F31NS062583 Sponsor/Mentor: Kenneth L. Tyler Individual Predoctoral Fellowship Award Recipient/Trainee: Stephanie Schittone Mechanisms of virus-induced motor neuron injury and treatment of viral myelitis 3/1/2008-2/28/2011 Department of Veterans Affairs Research Career Development Award
Recipient: Roberta DeBiasi, M.D Sponsor/Mentor: Kenneth L. Tyler, Role of apoptotic signaling pathways in virus-induced cell death and their role as targets for antiviral therapy. 12/1/02-11/31/05 NIH/NIAID 1 K08 AI52261
Recipient: Roberta DeBiasi, M.D. Mentor: Kenneth L. Tyler
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Apoptotic signaling in viral myocarditis 9/1/2002-5/31/2007 Department of Veterans Affairs Recipient/Trainee: David Beckham, M.D., Research Career Development Award (RCDA) Sponsor/Mentor: Kenneth L. Tyler Mechanisms of apoptosis in virus-infected neurons and brain 10/1/2007-9/30/2008
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Bibliography: I. Peer-reviewed Journals: 1.
Tyler KL, Poletti CE, Heros RC. Cerebral amyloid angiopathy with multiple intracerebral hemorrhages. J Neurosurg 57:286-289, 1982.
2.
Tyler KL, Alder D. Twenty-eight years of benign recurring Mollaret's meningitis. Arch Neurol 40:42-43, 1983.
3.
Tyler KL. Diagnosis and management of acute viral encephalitis. Semin Neurol 4:480-489, 1984.
4.
Tyler KL, Tyler HR. Answers to questions on stroke. Hospital Medicine. 19:206-228, July 1983 (Part I); 19:89-104, August 1983 (Part II).
5.
Tyler KL, Tyler HR. Differentiating organic dementia. Geriatrics. 39:38-52, 1984.
6.
Tyler KL, Bronson RT, Byers KB, Fields BN. The molecular basis of viral neurotropism: experimental reovirus infection. Neurology 35:88-92, 1985.
7.
Tyler KL, Gross RA, Cascino GD. Unusual viral causes of transverse myelitis: hepatitis A virus and cytomegalovirus. Neurology 36:855-858, 1986.
8.
Kaye KM, Spriggs DR, Bassel-Duby R, Fields BN, Tyler KL. Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing). J Virol 59:90-97, 1986. [PMC253042]
9.
Tyler KL, McPhee DA, Fields BN. Distinct pathways of viral spread in the host determined by reovirus S1 gene segment. Science 233:770-774, 1986.
10.
Bassel-Duby R, Spriggs DR, Tyler KL, Fields BN. Identification of attenuating mutations on the reovirus type 3 S1 double-stranded RNA segment with use of a rapid sequencing technique. J Virol 60:64-67, 1986. [PMC253902]
11.
Gonzalez-Scarano F, Tyler KL. Molecular pathogenesis of neurotropic viral infections. Ann Neurol 22:565-574, 1987.
12.
Tyler KL. Host and viral factors which influence viral neurotropism. I. Cell receptors and viral cell attachment proteins. Trends Neurosci 10:455-460, 1987.
13.
Tyler KL. Host and viral factors which influence viral neurotropism. II. Viral genes, host genes, site of entry and route of spread of virus. Trends Neurosci 10:492-497, 1987.
14.
Tyler KL, McPhee DA. Molecular and genetic aspects of the pathogenesis of viral infections of the central nervous system. Crit Rev Neurobiol 3:221-243, 1987.
15.
Tyler KL, Davis KR, Hedley-Whyte T. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 45-1988. A 67-year old woman with
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chronic lymphocytic leukemia, homonymous hemianopia, confusion, and poor balance (Progressive Multifocal Leucoencephalopathy). N Engl J Med 319:1268-1280, 1988. 16.
Virgin HW IVth, Bassel-Duby R, Fields BN, Tyler KL. Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing). J Virol 62:4594-4604, 1988. [PMC253571]
17.
Lipkin I, Tyler KL, Waksman BH. Viruses, the immune system and central nervous system diseases. Trends Neurosci 11:43-45, 1988.
18.
Leib DA, Coen DM, Bogard CL, Hicks KA, Yager DR, Knipe DM, Tyler KL, Schaffer PA. Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. J Virol 63:759-768, 1989. [PMC247748]
19.
Coen DM, Kosz-Vnenchak M, Jacobson JG, Leib DA, Bogard CL, Schaffer PA, Tyler KL, Knipe DM. Thymidine kinase negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia, but do not reactivate. Proc Natl Acad Sci U.S.A 86:4736-4740, 1989. [PMC287348]
20.
Tyler KL, Virgin HW IVth, Bassel-Duby R, Fields BN. Antibody inhibits defined stages in the pathogenesis of reovirus serotype 3 infection of the central nervous system. J Exp Med 170:887-900, 1989.
21.
Sacks SL, Wanklin RJ, Reece DE, Hicks KA, Tyler KL, Coen DM. Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? Ann Intern Med 111:893-899, 1989.
22.
Tyler KL. Pathogenesis of Reovirus infections of the central nervous system. Semin Neurosci 3:117-124, 1991.
23.
Virgin HW IVth, Tyler KL. The role of immune cells in protection against and control of reovirus infection in neonatal mice. J Virol 65:5157-5164, 1991. [PMC248992]
24.
Virgin HW IVth, Mann MA, Fields BN, Tyler KL. Monoclonal antibodies to reovirus reveal structure/function relationships between capsid proteins and genetics of susceptibility to antibody action. J Virol 65:6772- 6781, 1991. [PMC250764]
25.
Ravilochan K, Tyler KL. Human transmissible neurodegenerative diseases (prion diseases). Semin Neurol 12:178-192, 1992.
26.
Tyler KL, Mann MA, Fields BN, Virgin HW IVth. Protective anti-reovirus monoclonal antibodies and their effects on viral pathogenesis. J Virol 67:3446-3453, 1993. [PMC237690]
27.
Sherry B, Li X-L, Tyler KL, Cullen JM, Virgin HW IVth. Lymphocytes protect against, and are not required for, reovirus-induced myocarditis. J Virol 67: 6119-6124, 1993. [PMC238034]
28.
Watson CPN, Tyler KL, Bickers DR, Millikan LE, Smith S, Coleman E.
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A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia. Clin Ther 15:510-526,1993. 29.
Tedder DG, Ashley R, Tyler KL, Levin MJ. Herpes Simplex virus infection as a cause of benign recurrent lymphocytic meningitis. Ann Intern Med 121:334-338,1994.
30.
Virgin HW IVth, Mann MA, Tyler KL. Protective antibodies inhibit reovirus internalization and uncoating by intracellular proteases. J. Virol 68:6719-6729, 1994. [PMC237093]
31.
Tyler KL, Sandberg E, Baum KF. Medial medullary syndrome and meningovascular syphilis: A case report in an HIV-infected man, and review of the literature. Neurology 44: 2231-2235,1994.
32.
Tyler KL. Polymerase chain reaction and the diagnosis of viral CNS diseases. Ann Neurol 36: 809-811, 1994.
33.
Paskavitz JF, Anderson CA, Filley CM, Kleinschmidt-Demasters BK, Tyler KL. Acute arcuate fiber demyelinating encephalopathy following Epstein-Barr virus infection. Ann Neurol 38: 127-131, 1995.
34.
Dermody TS, Chappell JD, Hofler JG, Kramp W, Tyler KL. Eradication of persistent reovirus infection from a B-cell hybridoma. Virology 212:272-276, 1995.
35.
Tyler KL, Squier MKT, Rodgers SE, Schneider BE, Oberhaus SM, Grdina TA, Cohen JJ, Dermody TS. Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein σ1. J Virol 69:6972-6979, 1995. [PMC189616]
36.
Tyler KL, Tedder DG, Yamamoto LJ, Klapper JA, Ashley R, Lichtenstein KA, Levin MJ. Recurrent brainstem encephalitis associated with herpes simplex virus type 1 DNA in cerebrospinal fluid. Neurology 45: 2246-2250, 1995.
37.
Almond JW, Brown P, Gore SM, Hofman A, Wientjens PW, Ridley RM, Baker HF, Roberts GW, Tyler KL. Creutzfeldt-Jakob disease and bovine spongiform encephalopathy: any connection? BMJ (British Medical Journal) 311:1415-1421, 1995. {Tyler KL. Risk of human exposure to bovine spongiform encephalopathy. BMJ (British Medical Journal) 311: 1420-1421, 1995.]
38.
Tyler KL, Squier MKT, Brown AL, Pike B, Willis D, Oberhaus SM, Dermody TS, Cohen JJ. Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: Role of the S1 and M2 genes. J Virol 70:7984-7991, 1996. [PMC190871]
39.
Rodgers SE, Barton ES, Oberhaus SM, Pike B, Gibson CA, Tyler KL, Dermody TS. Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by bcl-2. J Virol 71: 2540-2546,1997. [PMC191370]
40.
Oberhaus SM, Smith RL, Clayton GH, Dermody TS, Tyler KL. Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. J Virol
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71:2100-2106,1997. [PMC191302] 41.
Oberhaus SM, Dermody TS, Tyler KL. Apoptosis and the cytopathic effects of reovirus. Curr Top Microbiol.Immunol 233/2:23-49, 1998.
42.
Tyler KL. Pathogenesis of reovirus infections of the central nervous system. Curr Top Microbiol Immunol 233/2:93-124, 1998.
43.
Virgin HW IVth, Dermody TS, Tyler KL. Cellular and humoral immunity to reovirus infection. Curr Top Microbiol Immunol 233/2:147-161, 1998.
44.
Tyler KL, Sokol RJ, Oberhaus SM, Mysan L, Murphy JR, Low R, Brown WR. Detection of reovirus RNA in hepatobiliary tissues from patients with extrahepatic bile duct atresia and choledochal cysts. Hepatology 27:1475-1482, 1998.
45.
Fodor PA, Levin MJ, Weinberg A, Sandberg E, Sylman J, Tyler KL. Atypical herpes simplex virus encephalitis diagnosed by PCR amplification of viral DNA from CSF. Neurology 51:554-559,1998.
46.
Kleinschmidt-DeMasters BK, Mahalingham R, Shimek C, Tyler KL, Gilden DH. Profound CSF pleocytosis and Froin’s syndrome secondary to widespread necrotizing vasculitis in varicella-zoster encephalomyelitis. J Neurol Sci 159:213-218, 1998.
47.
Pelosi E, Rozenberg F, Coen DM, Tyler KL. A Herpes Simplex virus DNA polymerase mutant that specifically attenuates neurovirulence in mice. Virology 252:364-372, 1998.
48.
DeBiasi RL, Squier MKT, Pike B, Wynes M, Dermody TS, Cohen JJ, Tyler KL. Reovirusinduced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. J. Virol. 73:695-701, 1999. [PMC103876]
49.
Clifford DB, Yiannoutsos C, Glicksman M, Simpson DM, Singer EJ, Piliero PJ, Marra CM, Francis GS, McArthur JC, Tyler KL, Tselis AC, Hyslop NE. HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy. Neurology 52:623-625,1999.
50.
DeBiasi RL, Tyler KL. Polymerase chain reaction in the diagnosis and management of nervous system infections. Arch Neurol 56:1215-1219, 1999.
51.
Anderson CA, Sandberg E, Filley CM, Harris SL, Tyler KL. One and one-half syndrome with supranuclear facial weakness. Magnetic resonance imaging localization. Arch Neurol 56:1509-1511,1999.
52.
Connolly JL, Rodgers SE, Clarke P, Ballard DW, Kerr LD, Tyler KL, Dermody TS. Reovirus-induced apoptosis requires activation of transcription factor NF-κB J Virol 74:2981-2989, 2000. [PMC111796]
53.
Yijuri T, Ware M, Widmann C, Oyer R, Russell D, Chan E, Zaitsu Y, Clarke P, Tyler KL, Oka Y, Fanger GR, Henson P, Johnson GL.MEK kinase 1 gene disruption alters cell
21
migration and c-Jun NH 2 -terminal kinase regulation but does not cause a measurable defect in NF-κB activation. Proc Natl Acad Sci U.S.A 97:7272-7277, 2000. [PMC16535] 54.
Clarke P, Meintzer SM, Gibson S, Widmann C, Garrington TP, Johnson GL, Tyler KL. Reovirus-induced apoptosis is mediated by TRAIL. J Virol 74: 8135-8139, 2000. [PMC112347]
55.
Poggioli GJ, Keefer C, Connolly JL, Dermody TS, Tyler KL. Reovirus-induced G 2 /M arrest requires σ1s and occurs in the absence of apoptosis. J Virol 74:9562-9570, 2000. [PMC112387]
56.
DeBiasi R, Edelstein C, Sherry B, Tyler KL. Calpain inhibition protects against virusinduced apoptotic myocardial injury J Virol 75:351-361, 2001. [PMC113928]
57.
Tyler KL, Clarke P, DeBiasi RL, Kominsky D, Poggioli G. Reovirus and the host cell.. Trends Microbiol 9:560-564, 2001.
58.
Poggioli GJ, Dermody TS, Tyler KL. Reovirus-induced σ1s-dependent G2/M cell cycle arrest is associated with inhibition of p34cdc2. J Virol 75:7429-7434, 2001. [PMC114978]
59.
DeMasters BK, DeBiasi R, Tyler KL. Polymerase chain reaction as a diagnostic adjunct in herpesvirus infections of the nervous system. Brain Pathol.11:452-464, 2001.
60.
Clarke P, Meintzer SM, Widmann C, Johnson GL, Tyler KL. Reovirus infection activates JNK-dependent transcription factor c-Jun. J Virol 75:11275-11283, 2001. [PMC114712]
61.
Clarke P, Meintzer SM, Spalding AC, Johnson GL, Tyler KL. Caspase-8 dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus infection. Oncogene 20:6910-6919, 2001.
62.
Spalding AC, Jotte RM, Scheinman RI, Geraci MW, Clarke P, Tyler KL, Johnson GL. TRAIL and inhibitors of apoptosis are opposing determinants for NFκB-dependent, genotoxin-induced apoptosis of cancer cells. Oncogene 21:260-271, 2002.
63.
Poggioli GJ, DeBiasi RL, Bickel, R., Bickel R, Jotte R, Spalding A, Johnson GL, Tyler KL. Reovirus-induced alterations in gene expression related to cell cycle regulation. J Virol 76:2585-2594, 2002. [PMC135961]
64.
Redington JJ, Tyler KL. Viral infections of the nervous system 2002. Update on diagnosis and treatment. Arch Neurol 59:712-718, 2002.
65.
DeBiasi RL, Kleinschmidt-DeMasters BK, Weinberg A, Tyler KL. Use of PCR for the diagnosis of herpesvirus infections of the central nervous system. J Clin Virol 25 (suppl):511, 2002.
66.
Kominsky D, Bickel RJ, Tyler KL. Reovirus induced apoptosis requires both deathreceptor- and mitochondrial-mediated caspase-dependent pathways of cell death. Cell Death and Differentiation 9:926-933, 2002.
22
67.
Richardson-Burns S, Tyler KL. Reovirus induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors. J Neurovirol 8:365-380, 2002.
68.
Weinberg A, Li S, Palmer M, Tyler KL. Quantitative CSF PCR in Epstein-Barr virus infections of the central nervous system. Ann Neurol 52:543-548, 2002.
69.
Kominsky DJ, Bickel R, Tyler KL. Reovirus-induced apoptosis requires mitochondrial release of Smac/DIABLO and involves reduction of cellular inhibitor of apoptosis protein levels. J Virol 76:11414-11424, 2002. [PMC136770]
70.
DeBiasi RL, Kleinschmidt-DeMasters BK, Richardson-Burns S, Tyler KL. Herpes simplex virus and cytomegalovirus encephalitis in humans are associated with CNS apoptosis. J Infect Dis 186:1547-1557, 2002.
71.
Richardson-Burns S, DeBiasi R, Kleinschmidt-DeMasters BK, Tyler KL. Progressive multifocal leukoencephalopathy is associated with apoptosis of infected oligodendrocytes in the CNS of AIDS and non-AIDS patients. Arch Neurol 59:1930-1936, 2002.
72.
Mann MA, Tyler KL, Knipe DM, Fields BN. Type 3 reovirus neuroinvasion after intramuscular inoculation: Viral genetic determinants of lethality and spinal cord infection. Virology 303:213-221, 2002.
73.
Clarke P, Tyler KL. Reovirus-induced apoptosis: A minireview. Apoptosis 8:141-150, 2003.
74.
Clarke P, Meintzer S, Moffitt L, Tyler KL. Two distinct phases of virus-induced NF-κB regulation enhance TRAIL-mediated apoptosis in virus-infected cells. J Biol Chem 278:18092-18100, 2003.
75.
Gonzales N, Tyler KL, Gilden DH. Recurrent dermatomal vesicular skin lesions. A clue to diagnosis of herpes simplex virus 2 meningitis. Arch. Neurol. 60:868-869, 2003.
76.
DeBiasi RL, Clarke P, Meintzer S, Jotte R, Kleinschmidt-DeMasters BK, Johnson GL, Tyler KL. Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis. J Virol 77: 8934-8947, 2003. [PMC167209]
77.
Cuevas BD, Abell AN, Witowsky JA, Yujiri T, Johnson NL, Kesavan K, Ware M, Jones PL, Weed SA, DeBiasi RL, Oka Y, Tyler KL, Johnson GL. MEKK1 regulates calpaindependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. EMBO J 22:3346-3355, 2003. [PMC165646]
78.
McCabe K, Tyler KL, Tanabe J. Diffusion-weighted MRI abnormalities: a clue to the diagnosis of herpes simplex encephalitis. Neurology 61:1015-1016, 2003.
79.
Edelmann KH, Richardson-Burns S, Alexopoulou L, Tyler KL, Flavell RA, Oldstone MBA. Does Toll-like receptor 3 play a biological role in virus infections? Virology 322:231-8, 2004.
23
80.
Richardson-Burns SM, Tyler KL. Regional differences in viral growth and CNS injury correlate with apoptosis. J Virology 78:5466-75, 2004. [PMC400348]
81.
Tyler KL, Barton ES, Ibach ML, Robinson C, Campbell JA, O’Donnell SM, Valyi-Nagy T, Clarke P, Wetzel JD, Dermody TS. Isolation and characterization of a novel type 3 reovirus from a child with meningitis. J Infect Dis 189:1664-75, 2004.
82.
Hoyt C, Bouchard R, Tyler KL. Novel nuclear herniations induced by nuclear localization of a viral protein. J Virology 78:6360-6369, 2004. [PMC416550]
83.
Tyler KL, West Nile virus in the United States. Arch Neurol 61:1190-1195, 2004.
84.
Kleinschmidt-DeMasters BK, Marder B, Levi M, Laird SP, McNutt T. Escott E, Everson GT, Tyler KL. Naturally-acquired West Nile virus encephalomyelitis in transplant recipients: Clinical, laboratory, diagnostic and neuropathological features. Arch Neurol 61:1210-1220, 2004.
85.
Tyler, KL. Herpes simplex virus infections of the central nervous system: Encephalitis and meningitis, including Mollaret’s. Herpes 11 (suppl 2):57A-64A, 2004.
86.
DeBiasi RL, Tyler KL. Molecular methods for diagnosis of viral encephalitis. Clinical Microbiol Rev. 17:903-925, 2004. [PMC523566]
87.
DeBiasi RL, Robinson BA, Sherry B, Bouchard R, Brown RD, Rizeq M, Long C, Tyler KL. Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo. J. Virol. 78:11040-11050, 2004. [PMC521817]
88.
Clarke P, Meintzer SM, Wang Y, Moffitt LA, Richardson-Burns SM, Johnson GL, Tyler KL. JNK regulates the release of pro-apoptotic mitochondrial factors in reovirus-infected cells. J. Virology 78:13132-13138, 2004. [PMC524973]
89.
Tyler KL. Infectious Diseases: West Nile virus. Rev. Neurol. Dis. 1:49-51, 2004.
90.
Tyler KL. West Nile virus infection. Rev. Neurol. Dis. 1:83-90, 2004.
91.
Tyler KL. Update on herpes simplex encephalitis. Rev. Neurol. Dis. 1:169-178, 2004.
92.
Weinberg A, Bloch KC, Li S, Tang Y-W, Palmer M, Tyler KL. Dual infections of the central nervous system with Epstein-Barr virus. J. Infect. Dis. 191:234-237, 2005.
93.
Hoyt C, Richardson-Burns S, Goody R, Tyler KL. Reovirus non-structural protein σ1s is a determinant of virulence in the heart and CNS. J. Virol. 79:2743-2753, 2005. [PMC548430]
94.
Beckham JD, Tyler KL. Progressive multifocal leukoencephalopathy following natalizumab therapy. Rev.Neurol. Dis. 2:158-163, 2005.
95.
Tyler KL, Khalili K. Natalizumab and progressive multifocal leukoencephalopathy.. Rev.
24
Neurol. Dis. 2:144-149, 2005. 96.
Richardson-Burns, SM, Tyler KL. Minocycline delays disease onset and mortality in a murine model of viral encephalitis. Exp. Neurol. 192:331-339, 2005. [PMC2362387]
97.
Clarke P, Richardson-Burns SM, DeBiasi RL, Tyler KL. Mechanisms of apoptosis during reovirus infection. Curr. Topics Microbiol. Immunol. 289: 1-24, 2005. [PMC2367090]
98.
Clarke P, DeBiasi RL, Goody R, Hoyt CC, Richardson-Burns S, Tyler KL. Mechanisms of reovirus-induced cell death and tissue injury: Role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation. Viral Immunol. 18:89-116, 2005. [PMC2366905]
99.
Clarke P, DeBiasi RL, Meintzer SM, Robinson BA, Tyler KL. Inhibition of NF-κB activity and cFLIP expression contribute to viral-induced apoptosis. Apoptosis 10:513-524, 2005.
100. Le SS, Loucks A, Udo H, Richardson-Burns S, Phelps RA, Bouchard RJ, Barth H, Aktories K, Tyler KL, Kandel ER, Heidenreich KA, Linseman DA. Inhibition of Rac GTPase triggers a c-Jun and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. J. Neurochem. 94:1025-39, 2005. [PMC2366110] 101. DeMasters BK, Tyler KL. Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon-β-1a for multiple sclerosis. N. Engl. J. Med. 353:369-374, 2005. 102. Goody RJ, Hoyt CC, Tyler KL. Reovirus infection of the CNS enhances iNOS expression in areas of virus-induced injury. Exp. Neurol. 195:379-90, 2005. [PMC2367058] 103. Lapadat R, DeBiasi RL, Johnson GL, Tyler KL. Genes induced by reovirus infection have a distinct modular cis-regulatory arrangement. Current Genomics 6:501-514, 2005. 104. Tyler KL, Pape J, Goody RJ, Corkill M, Kleinschmidt-DeMasters BK. CSF in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis. Neurology 66:361-365, 2006. 105. Debiasi RL, Tyler KL. West Nile virus meningoencephalitis. Nature Clin. Pract. Neurol. 2: 264-275, 2006. 106. Beckham JD, Tyler KL. Initial management of acute bacterial meningitis in adults: Summary of IDSA guidelines. Rev. Neurol. Dis. 3:57-60, 2006. 107. Davis LE, DeBiasi RL, Goade DE, Haaland KY, Harrington JA, Harnar JB, Pergam SA, King MK, DeMasters, B.K., Tyler KL. West Nile virus neuroinvasive disease. Annals Neurol. 60:286-300, 2006. 108. Clarke P, Tyler KL. Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis. Apoptosis 12:211-223, 2007. [PMC2365758]
25
109. Gilden DH, Mahalingam R, Cohrs RJ, Tyler KL. Herpesvirus infections of the nervous system. Nature Clin. Pract. Neurology 3:82-94, 2007. 110. Tyler KL, Aksamit AJ, Keegan BM, Parisi JE. An 85-year-old man with chronic lymphocytic leukemia and altered mental status. Neurology 68:460-7, 2007. 111. Anderson CA, Bosque P, Filley CM, Arciniegas DB, Kleinschmidt-DeMasters BK, Pape JW, Tyler KL. Colorado surveillance program for chronic wasting disease transmission to humans: lessons from two highly suspicious but negative cases. Arch. Neurol. 64:439441, 2007. 112. Beckham JD, Goody RJ, Clarke P, Bonny C, Tyler KL. Novel strategy for the treatment of viral central nervous system infection by using a cell-permeable inhibitor of c-Jun Nterminal kinase. J. Virol. 81:6984-6992, 2007. [PMC1933289] 113. Goody R, Rutsova K, Beckham, D, Tyler KL. J. Neurovirol. JAK-STAT signaling pathways are activated in the brain following reovirus infection. J. Neurovirol. 13:373-383, 2007. [PMC2367059] 114. Zimmerman AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA. Glutathione binding to the BCL-2 homology-3 domain groove: A molecular basis for BCL2 antioxidant function at mitochondria. J. Biol. Chem. 282:29296-29304, 2007 [PMC 2386251] 115. Beckham JD, Tyler KL. Infectious disease-Developments in the field of Creutzfeldt-Jakob disease. Rev. Neurol Dis. 4: 168-172, 2007. [PMC2613287] 116. Hudson LA, Rollins YD, Anderson CA, Johnston-Brooks C, Tyler KL, Filley CM. Reduplicative paramnesia in Morvan’s syndrome. J. Neurol. Sci.267:154-157, 2008. 117. Tyler KL, Beckham JD. Management of acute shingles (herpes zoster). Rev. Neurol. Dis. 4: 203-208, 2007. 118. Hall DA, Tyler KL, Frey KL, Kozora E, Arciniegas DB. Persistent neurobehavioral signs and symptoms following West Nile Fever. J. Neuropsychiatry & Clin. Neurosci. 20:122123, 2008. 119. Goody RJ, Schittone SA, Tyler KL. Experimental reovirus-induced acute flaccid paralysis and spinal motor neuron cell death. J. Neuropathol. Exp. Neurol. 67:231-239, 2008. [PMC2365907] 120. Tyler KL. Acute pyogenic discitis (spondylodiscitis) in adults. Rev. Neurol. Dis. 5:8-13, 2008. 121. Davis LE, Beckham JD, Tyler KL. North American encephalitic arboviruses. Neurol. Clin. 26 :727-757, 2008. [PMC2866042] 122. Tyler KL. Genes determining susceptibility to human herpes simplex virus encephalitis.
26
Rev. Neurol. Dis. 5: 206-8, 2008. 123. Tyler KL. Neurological infections: Advances in therapy, outcome and prediction. Lancet Neurol. 8:19-21, 2009. 124. Clarke P, Tyler KL. Apoptosis in animal models of virus-induced disease. Nature Rev. Microbiol. 7:144-55, 2009. [PMC2772826] 125. Tyler KL. Prednisolone-but not antiviral drugs-improves outcome in patients with Bell’s palsy. Nature Clin Prac Neurology 5:74-5, 2009. 126. Beckham JD, Tuttle K, Tyler KL. Reovirus activates TGF-β and BMP signaling pathways in the CNS which contribute to neuronal survival following infection . J. Virol. 83:503545, 2009. [PMC2687381] 127. Boster A, Hreha S, Berger JR, Bao F, Penmesta R, Tselis A, Endress C, Zak I, Perumal J, Caon C, Vazquez J, Tyler KL, Racke MK, Mills S, Khan O. Progressive multifocal leukoencephalopathy and relapsing-remitting multiple sclerosis: a comparative study. Arch. Neurol. 66:593-599, 2009. 128. Clarke P, Hoyt C, Beckham JD, Tyler KL. Fas-mediated apoptotic signaling in the mouse brain following reovirus infection. J. Virol. 83:6165-6170, 2009. [PMC2687381] 129. Miyamoto SD, Brown RD, Robinson BA, Tyler KL, Long CS, DeBiasi RL. Cardiac cellspecific apoptotic and cytokine responses to reovirus Infection: Determinants of myocarditic phenotype. J Card Fail 15:529-39, 2009. [PMC2772824]. 130. Levi ME, Quan D, Ho JT, Kleinschmidt-DeMasters BK, Tyler KL, Grazia TJ. Impact of rituximab-associated B cell defects on West Nile virus meningoencephalitis in solid organ transplant recipients. Clin Transplantation 24:223-8, 2009. [PMC2873850] 131.
Korman BD, Tyler KL, Korman NJ. Progressive multifocal leukoencephalopathy, efalizumab, and immunosuppression: a cautionary tale for dermatologists. Arch. Derm. 145:937-42, 2009.
132. Tyler KL. Emerging viral infections of the central nervous system: Part 1. Arch. Neurol. 66:939-48, 2009. [PMC2873855] 133. Tyler KL. Emerging viral infections of the central nervous system. Part II. Arch. Neurol. 66:1065-74, 2009. [PMC2876734] 134. Blakely P, Kleinschmidt-DeMasters BK, Tyler KL, Irani D. Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection. J. Neuropathol. Exp. Neurol. 68:1061-72, 2009. [PMC2854566] 135. Tyler KL, Leser JS, Phang TL, Clarke P. Gene expression in the brain during reovirus encephalitis. J. Neurovirol. 16:56-71, 2010. [PMC2891017] 136. Beckham JD, Tuttle K, Tyler KL. Caspase 3 activation is required for reovirus-induced
27
encephalitis in vivo. J Neurovirol. 16:306-17, 2010. [PMC3023174]] 137. Dionne KR, Leser JS, Lorenzen KA, Beckham JD, Tyler KL. A brain slice culture model of viral encephalitis reveals an innate CNS cytokine response profile and the therapeutic potential of caspase inhibition. Exp. Neurol 228:222-31, 2011. [PMC3060973] 137. Berens HM, Tyler KL. The pro-apoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis. J. Virol. 85:3858-71, 2011. 138. Clifford DB, Ances B, Costello C, Rosen-Schmidt S, Andersson M, Parks D, Perry A, Yerra R, Schmidt R, Alvarez E, Tyler KL. Rituximab associated progressive multifocal leukoencephalopathy in rheumatoid arthritis . Arch. Neurol. (epub ahead of print 9 May), 2011. [PMID 21555606] 139. Dionne KR, Galvin JM, Schittone SA, Clarke P, Tyler KL. Type I interferon signaling limits reoviral tropism within the brain and prevents lethal systemic infection. J. Neurovirol. 17:314-26, 2011. [PMID 21671121] 140. Clifford DB, Ances B, Costello C, Rosen-Schmidt S, Andersson M, Parks D, Perry A, Yerra R, Schmidt R, Alvarez E, Tyler KL. Rituximab associated progressive multifocal leukoencephalopathy in rheumatoid arthritis . Arch. Neurol. 68:1156-1164, 2011. [PMID 21555606] 141.
Wilson MR, Tyler KL. Issues and updates in emerging neurologic viral infections. Semin. Neurol. 31:245-53, 2011. [PMID 21964843].
142.
Beckham JD, Tyler KL. Neuro-intensive care of patients with acute CNS infections. Neurotherapeutics, (epub ahead print 19 Nov, 2011). [PMID 22102180].
143.
Stankiewicz TR, Loucks FA, Schroeder EK, Nevalainen MT, Tyler KL, Aktories K, Bouchard RJ, Linseman DA. Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by the inhibition of Rac GTPase activity J. Biol. Chem. 287:16835-48, 2012. [PMID: 22378792].
144.
Schittone S, Dionne K, Tyler KL, Clarke P. Activation of innate immune responses in the CNS during reovirus myelitis. J.Virol. 86:8107-18, 2012. [PMC3421655]
145.
Beatman, E., Oyer R, Shives KD, Hedman K, Brault AC, Tyler KL, Beckham JD. West Nile virus growth is independent of autophagy activation. Virology 433:262-72, 2012 [PMC3444629]
146.
Dionne K, Zhuang Y, Tyler KL, Clarke P. Daxx upregulation in the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis. J. Virol. 87:3447-3460, 2013 [PMC3592169].
147.
Tyler KL, Johnson EC, Cantu DS, Haller BL. A 20-year-old woman with headache and transient numbness. The Neurohospitalist 3:101-110, 2013. [PMC3726119]
148.
Davis LE, Oyer R, Beckham JD, Tyler KL. Elevated CSF cytokines in the Jarisch-
28
Herxheimer reaction of general paresis. JAMA Neurol. 70: 1060-1064, 2013. [PMID23732875]. 149.
Nath A, and Tyler KL. Novel approaches and challenges to treatment of CNS viral infections. Ann. Neurol. 74:412-22, 2013. [PMID23913580].
150.
Dionne KR, Tyler KL. Slice culture modeling of central nervous system (CNS) viral infection. Methods Mol. Biol. 1078:97-117, 2013. [PMID23975824].
151.
Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death receptor mediated apoptotic signaling is activated in the brain following infection with West Nile Virus in the absence of a peripheral immune response. J. Virol 88:1080-9, 2014. [PMC3911655].
152.
Tyler KL. Current developments in understanding of West Nile virus central nervous system disease. Curr. Opin. Neurol 27:342-8, 2014. [PMID 24722324]
153.
Clarke P, Leser JS ,Bowen RA , Tyler KL. Virus-induced transcriptional changes in the brain include the differential expression of genes associated with interferon, apoptosis, IL17RA and glutamate signaling as well as the flavivirus-specific up-regulation of tRNA synthetases. MBio 5(2):e00902-14. doi. 10.1128/mBio.00902-14. [PMC3952157].
154. Quick, ED., Leser JS., Clarke P, Tyler K. Activation of intrinsic immune responses and microglial phagocytosis in an ex vivo spinal cord slice model of West Nile virus infection. J. Virol. 88:13005-13014, 2014. [PMC4249089].
II.
History of Neurology (Original Articles and Book Chapters)
1.
Tyler KL, McHenry LC Jr. Classics in Neurology: Pseudohypertrophic muscular dystrophy and Gower's sign. Neurology. 33:88-89, 1983.
2.
Tyler KL. Classics in Neurology: "Tetanoid Chorea" and progressive lenticular degeneration. Neurology. 33:461-462, 1983.
3.
Tyler KL, McHenry LC Jr. Classics in Neurology: The knee jerk and other tendon reflexes. Neurology. 33:609-610, 1983.
4.
Tyler KL. Hughlings Jackson: The early development of his ideas on epilepsy. J. Hist. Med Allied Sci. 39:55-64, 1984.
5.
Tyler HR, Tyler KL. Charles Edouard Brown-Sequard: professor of physiology and pathology of the nervous system at Harvard Medical School. Neurology. 34:1231-1236, 1984.
6.
Tyler HR, Tyler KL. Classics in Neurology: “Organic remains of a former world”. Neurology 35:371, 1985.
7.
Tyler HR, Tyler KL. Classics in Neurology: Drawings of Leonardo da Vinci. Neurology
29
35:636, 1985. 8.
Tyler HR, Tyler KL. Classics in Neurology: Communication between lateral and third ventricle: First description. Neurology 35: 1298, 1985.
9.
Tyler KL, Tyler HR. The secret life of James Parkinson (1755-1824): The writings of Old Hubert. Neurology. 36:222-224, 1986.
10.
Tyler KL. A History of Parkinson's Disease. In: Koller WC (Ed.). Handbook of Parkinson's Disease. M Dekker Inc., NY, 1987:1-33.
11.
Tyler KL, Vignette: William G. Spiller (1863-1940). Annals Neurol. 31: 686, 1992.
12.
Tyler KL. A History of Parkinson's Disease. In: Koller WC (Ed.).Handbook of Parkinson's Disease (2nd ed.) M. Dekker Inc., NY, 1992:1-34.
13.
Tyler HR, Tyler KL. Cushing: The book collector. In: Black P, Moore M, Rossitch E (Eds.). Harvey Cushing at the Brigham. Amer. Assoc. Neurological Surgeons, Park Ridge, IL, 1995. Tyler KL, Tyler HR. Sir William Richard Gowers (1845-1915): Exhumation and decoding of his shorthand publications. In: Rose FC (Ed.): A short history of neurology. The British Contribution 1660-1910. Butterworth-Heinemann, Oxford,1999:208-221.
14.
15.
Tyler KL, Roberts D, Tyler HR. The shorthand publications of Sir William Richard Gowers. Neurology 55:289-293, 2000.
16.
Tyler KL, Malessa R. The Goltz-Ferrier debates and the triumph of cerebral localizationist theory. Neurology 55:1015-1024, 2000.
17.
Tyler KL. Gowers, William Richard In: Aminoff MJ, Daroff RB (Eds.). Encyclopedia of the neurological sciences. Academic Press, Amsterdam, 2003: vol. 2:481-484.
18.
Tyler KL. Mitchell, Silas Weir. In: Aminoff MJ, Daroff RB (Eds.). Encyclopedia of the neurological sciences. Academic Press, Amsterdam, 2003: vol. 3:183-190.
19.
Tyler KL. Goltz, Friedrich Leopold. In: Aminoff MJ, Daroff RB (Eds.). Encyclopedia of the neurological sciences. Academic Press, Amsterdam, 2003: vol. 2:479-480.
20.
Tyler KL. Hitzig, Eduard. In: Aminoff MJ, Daroff RB (Eds.). Encyclopedia of the neurological sciences. Academic Press, Amsterdam, 2003: vol. 2:560-561.
21.
Tyler KL, York GK, Steinberg DA et al. History of 20th century neurology: decade by decade. Ann Neurol 53 (suppl 4): S27-S45, 2003.
22.
Tyler KL. Origins and early descriptions of “Duchenne muscular dystrophy”. Muscle & Nerve 28:402-422, 2003.
23.
Tyler KL. William Richard Gowers (1845-1915). J Neurol. 250:1012-1013, 2003.
30
24.
25.
Tyler KL. A history of bacterial meningitis. In: Finger S, Boller F, Tyler KL (Eds.): History of Neurology, Handbook of Clinical Neurology, 3rd Series, Elsevier, NY, 2010: 95:417-433. Tyler KL and Tyler HR. The appointment of Dr. Derek Denny-Brown as head of the Neurologic Unit at Boston City Hospital and Harvard Medical School. In: The Cradle of American Neurology: The Harvard Neurological Unit at the Boston City Hospital, Dawson DM, Sabin TD (Eds.), HoLLis Publishing, Hoollis NH, 2011:63-81
26.
Tyler KL, Goltz, Fredrich Lopold. In Encyclopedia of the Neurological Sciences (2nd edition), Daroff RB, Aminoff MJ (Eds). Elsevier, NY, 2014: vol. 2: 469-470.
27.
Tyler KL. Gowers, William Richard in Encyclopedia of the Neurological Sciences (2nd ed), Daroff RB, Aminoff MJ (Eds). Elsevier, NY, 2014, vol. 2:471-474.
28.
Tyler KL. Hitzig, Eduard. In Encyclopedia of the Neurological Sciences (2nd edition) Elsevier, Daroff RB, Aminoff MJ (Eds). NY, 2014: vol. 2:580-581.
29.
Tyler KL. Mitchell, Silas Weir In: Encyclopedia of the Neurosciences (2nd edition). Daroff MB, Aminoff MJ (Eds.), Elsevier, NY 2014: vol. 2:78-80
31
III.
Book Chapters
1.
Folkman J, Tyler K. Tumor Angiogenesis: Its Possible Role in Metastasis and Invasion. In: Day SB, Stacey B. et al. (ed.). Progress in Cancer Research and Therapy, Vol. 5. Cancer Invasion and Metastasis: Biological Mechanisms and Therapy. Raven Press. NY, 1977:95-103.
2.
Tyler KL, Tyler HR. Huntington's Disease. In: Tyler HR and Dawson D (Eds.). Current Neurology. Houghton Mifflin, Boston, (Volume I), 1978:116-141.
3.
Tyler HR, Tyler KL. Parkinson's Disease. In: Tyler HR and Dawson D (Eds.). Current Neurology. Houghton Mifflin, Boston, (Volume I), 1978:142-165.
4.
Tyler KL. Huntington's Disease Update. In: Tyler HR and Dawson D (Eds.). Current Neurology. Houghton Mifflin, Boston, (Volume II), 1979:157-167.
5.
Tyler KL. Parkinson's Disease Update. In: Tyler HR and Dawson D (Eds.). Neurology. Houghton Mifflin, Boston, (Volume II), 1979:168-181.
6.
Tyler KL, Tyler HR. Neurologic Complications of Uremia. In: Eknoyan G, Knochel J (Eds.) Systemic Consequences of Renal Failure. Grune & Stratton, 1984:311-330.
7.
Tyler KL. Seizures. In: Hyman S (Ed.). Manual of Psychiatric Emergencies. Little Brown, Boston, 1984:161-169.
8.
Tyler KL, Fields BN. Reoviruses. In: Fields BN, Knipe DM, Chanock RM, Melnick JL, Roizman B, Shope RE (Eds.): Virology. Raven Press, NY, 1985:817-822.
9.
Tyler KL, Fields BN. Reovirus and its Replication. In: Fields BN, Knipe DM, Chanock RM, Melnick JL, Roizman B, Shope RE (Eds.): Virology. Raven Press, NY, 1985:823-863.
10.
Tyler KL, Fields BN. Reoviruses. In: Fields BN and Knipe DM (Eds.): Fundamental Virology. Raven Press, NY, 1986:391-395. [republication of #8]
11.
Tyler KL, Fields BN. Reovirus and its Replication. In: Fields BN and Knipe DM (Eds.): Fundamental Virology. Raven Press, NY, 1986:397-436. [republication of #9]
12.
Tyler KL, Tyler HR. Neurologic Manifestations of Endocrine Diseases. In: Asbury A, McKahn G, McDonald WI (Eds.). Diseases of the Nervous System. Saunders, Philadelphia, 1986:1552-1562.
13.
Tyler KL. Localized Infections of the Central Nervous System. In: Current Therapy in Infectious Disease. Kass EH, Platt R (Eds.). BC Decker, Philadelphia, 1986:216-225.
14.
Tyler KL, Fields BN. Reovirus Infections in Laboratory Rodents. In: Bhatt PN et al.
Current
32
(Eds.). Viral and Mycoplasmal Infections of Laboratory Rodents: Effects on Biomedical Research. Academic Press, NY, 1986:277-303. 15.
Tyler KL, Fields BN. Principles of Virology. In: Braunwald E, Isselbacker J, Petersdorf RG et al. (Eds.). Harrison's Principles of Internal Medicine (11th edition), McGraw Hill, NY, 1987:659-668.
16.
Tyler KL. Localized Infections of the Central Nervous System. In: Current Therapy in Internal Medicine-2. Bayless TM, Brain MC, Cherniak RM (Eds.). BC Decker, Philadelphia, 1987:231-240. [republication of #13]
17.
Tyler KL. Encephalitis. In: Adelman G. (Ed.). Encyclopedia of Neuroscience. Birkhauser, Boston, 1987:387-389.
18.
Tyler KL. The Neurologic Examination (Chapter 151), Aphasia (Chapter 154), Epilepsy (Chapter 156), Multiple Sclerosis (Chapter 161), Parkinson's Disease (Chapter 162), Chronic Progressive Myopathies and Muscular Dystrophies (Chapter 167), Amyotrophic Lateral Sclerosis (Chapter 168), Alcoholism (Chapter 176). In: Braunwald E, Isselbacher KJ, Petersdorf RG, Wilson JD, Martin JB, Fauci AS (Eds.). Harrison's Principles of Internal Medicine (11th ed.) Companion Handbook. McGraw-Hill, NY, 1988.
18.
Tyler KL. Host and Viral Factors Which Influence Viral Neurotropism. In: Harding A and Rosenberg R (Eds.). The Molecular Biology of Neurological Disease. Butterworths, London, 1988:94-108.
20.
Tyler KL, Fields BN. Reovirus Infections of the Central Nervous System. In: Johnson RT, Lyon G (Eds.). Viral Infections of the Developing Nervous System. Kluwer, Dordecht, 1988:11-19.
21.
Tyler KL, Fields BN. Reoviridae: The Reoviruses. In: Lennette EH, Halonen P, Murphy FA (Eds.). Laboratory Diagnosis of Infectious Disease, Principles and Practice (Vol. II). Springer-Verlag, NY, 1988:353-374.
22.
Tyler KL, Fields BN. Pathogenesis of Neurotropic Viral Infections: In: McKendall RR (Ed.). Viral Disease (Handbook of Clinical Neurology, revised series, Vol. 12(56). Elsevier, Amsterdam 1989:25-49.
23.
Tyler KL. Fields BN. Pathogenesis of Viral Infections. In: Fields BN, Knipe DM (Eds.). Virology (2nd ed.), Raven Press, NY 1990:191-239.
24.
Tyler KL, Fields BN. Reoviridae: A Brief Introduction. In: Fields BN, Knipe DM (Eds.). Virology (2nd ed.), Raven Press, NY, 1990:1271-1273.
25.
Tyler KL. Fields BN. Reoviruses. In: Fields BN, Knipe DM (Eds.).Virology (2nd ed.), Raven Press, NY, 1990:1307-1328.
33
26.
Lehrich JR, Tyler KL. Slow Infections of the Central Nervous System. In: Mandell GL, Douglas RG, Bennett JE (Eds.). Principles and Practice of Infectious Diseases (3rd ed.). Churchill Livingstone, NY 1990:769-777.
27.
Tyler KL, Fields BN. Introduction to Viruses and Virus Diseases. In: Mandell GL, Douglas RG, Bennett JE (Eds.). Principles and Practice of Infectious Diseases (3rd ed.), Churchill Livingstone, NY 1990:1124-1134.
28.
Tyler KL. Prions. In: Mandel GL, Douglas RG, Bennett JE (Eds.). Principles and Practice of Infectious Diseases (3rd ed.), Churchill Livingstone, NY 1990:1419-1423.
29.
Tyler KL. Infections: Viruses. In: Pearlman AL and Collins R (Eds.). Neurobiology of Disease. Oxford Univ. Press, NY 1990:435-453.
30.
Tyler KL. Localized Infections of the Central Nervous System. In: Current Therapy in Internal Medicine (3rd ed.). Kassirer JP (Ed). BC Decker, Philadelphia 1991:199-209.
31.
Tyler KL, Fields BN. Pathogenesis of Viral Infections. In: Fields BN, Knipe DM (Eds.). Fundamental Virology (2nd ed.), Raven Press, NY 1991:191-239. [republication of #23]
32.
Tyler KL, Fields BN. Reoviridae: A Brief Introduction. In: Fields BN, Knipe DM (Eds.). Fundamental Virology (2nd ed.), Raven Press, NY, 1991:583-585. [republication of #24]
33.
Tyler KL, Fields BN. The Biology of Viruses. In: Wilson J, Braunwald E, Isselbacher KJ, et al. (Eds.). Harrison's Principles of Internal Medicine (12th edition), McGraw Hill, NY, 1991:669-677.
34.
Tyler KL. The Neurologic Examination (Chapter 154), Epilepsy (Chapter 157), Multiple Sclerosis (Chapter 162), Parkinson's Disease Chapter 163), Amyotrophic Lateral Sclerosis (Chapter l65), Chronic Progressive Myopathies and Muscular Dystrophies (Chapter 170), Aphasia (Chapter 173), Alcoholism (Chapter 179). In: Wilson JD, Braunwald E, Isselbacher KJ, et al., (eds.). Harrison's Principles of Internal Medicine (12th ed.) Companion Handbook. McGraw-Hill, NY, 1991.
35.
Tyler KL, Martin JB, Scheld WM. Focal Suppurative Infections of the Central Nervous System. In: Tyler KL, Martin JB (Eds.): Infectious Diseases of the Central Nervous System, FA Davis, NY, 1993: 157-175.
36.
Martin JB, Tyler KL, Scheld WM. Bacterial Meningitis. In: Tyler KL, Martin JB (Eds): Infectious Diseases of the Central Nervous System, FA Davis, NY, 1993: 176-187.
37.
Tyler KL. The Neurological Examination (Chapter 160), Epilepsy (Chapter 162), Viral Infections of the Nervous System, Including Slow Viruses (Chapter 166), Multiple Sclerosis (Chapter 167), Parkinson's Disease (Chapter 169), Motor Neuron Disease Including ALS (Chapter 170),Aphasia (Chapter 172), Myopathies and Muscular Dystrophies (Chapter 180), Alcoholism (Chapter 185). In: Isselbacher KJ, Braunwald E,
34
Wilson JD, et al. (Eds.). Harrison's Principles of Internal Medicine (13th ed.) Companion Handbook, McGraw-Hill, NY, 1995. 38.
Tyler KL. Pathogenesis. In: Webster RG, Granoff A (Eds). Encyclopedia of Virology, Academic Press, London, 1994: 1076-1083.
39.
Tyler KL, Fields BN. The Biology of Viruses. In: Isselbacher KJ, Braunwald E, Wilson JD, et. al.(Eds.): Harrison's Principles of Internal Medicine (13th ed.). McGraw Hill, NY, 1994:768-776.
40.
Tyler KL. Viral and Prion Diseases of the Nervous System. In: Isselbacher KJ, Braunwald E, Wilson J, Martin J, Fauci A, Kasper D (Eds.): Harrison's Principles of Internal Medicine (l3th edition), McGraw-Hill, NY, 1994: 2309-2320.
41.
Tyler KL, Blume GM. Herpes Simplex Encephalitis. In: Feldman, E. (Ed.): Current Diagnosis in Neurology, Mosby-Yearbook Inc., St. Louis, Missouri, 1994: 88-92.
42.
Tyler KL. Animal Models of Reovirus Infection. In: McKendall RR, Stroop WG (Eds.): Handbook of Neurovirology. Marcel Dekker, Inc., NY,1994: 671-679.
43.
Tyler KL. Prion Diseases of the Central Nervous System. In: Mandell GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (4th ed). Churchill Livingstone, NY, 1995: 881-887.
44.
Tyler KL, Fields BN. Introduction to Viruses and Virus Diseases. In: Mandel GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (4th ed), Churchill Livingstone, NY, 1995:1314-1325.
45.
Tyler KL. Prions. In: Mandel GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (4th ed.), Churchill Livingstone, NY, 1995:1674-76.
46.
Tyler KL, Fields BN. Pathogenesis of Viral Infections. In: Fields BN, Knipe DM, Howley PM (Eds.) Virology (3rd ed). Lippincott-Raven, Philadelphia, 1996:173-218.
47.
Tyler KL, Fields BN. Reoviruses. In: Fields BN, Knipe DM, Howley PM (Eds.): Virology (3rd ed). Lippincott-Raven, Philadelphia, 1996:1597-1623.
48.
Tyler KL, Fields BN. Pathogenesis of Viral Infections. In: Fields BN, Knipe DM, Howley PM (Eds). Fundamental Virology (3rd ed.), Lippincott-Raven, Philadelphia, 1996:161-206. [republication of #46]
49.
Pfister HW, Tyler KL. Other Spirochetal Infections. In: Brand T, Caplan LR, Dichgans J, Diener HC, Kennard C (Eds.). Neurological Disorders: Course and Treatment, Academic Press, San Diego, 1996:423-432.
50.
Malessa R, Tyler KL. Viral Infections of the Central Nervous System. In: Brandt T,
35
Caplan LR, Dichgans J, Diener HC, Kennard C (Eds.). Neurological Disorders: Course and Treatment, Academic Press, San Diego, 1996:443-454. 51.
Nathanson N, and Tyler KL. Entry, Dissemination, Shedding, and Transmission of Viruses. In: Nathanson N (Ed.) Viral Pathogenesis, Lippincott-Raven, Philadelphia, 1997:13-33.
52.
Virgin HW IVth, Tyler KL, Dermody TS. Reovirus. In: Nathanson N (Ed.). Viral Pathogenesis, Lippincott-Raven, Philadelphia, 1997:669-699.
53.
Tyler KL, Gonzalez-Scarano F. Viral Diseases of the Central Nervous System: Acute Infections. In: Nathanson N (Ed.). Viral Pathogenesis, Lippincott-Raven, Philadelphia, 1997:837-853.
54.
Nathanson N. and Tyler KL. The Pathogenesis of Viral Infections. In: Collier L (ed.). Topley & Wilson's Microbiology and Microbial Infections (9th ed.), Vol. I: Mahy BWJ, Collier LH (Eds.). Virology, Edward Arnold, London, 1997:149-172.
55.
Tyler KL. Aseptic meningitis, viral encephalitis, and prion diseases. In: Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL (Eds.). Harrison’s Principles of Internal Medicine (14th ed.), McGraw-Hill, NY, 1998:24392451.
56.
Tyler KL. The Neurological Examination (Chapter 171), Bacterial Infections of the Central Nervous System (Chapter 176), Aseptic Meningitis, Viral Encephalitis, and Prion Diseases (Chapter 177), Motor Neuron Disease, Including ALS (Chapter 182), Aphasia (Chapter 183). In: Fauci AS, Braunwald E, Isselbacher KJ, et al. (Eds.) Harrison’s Principles of Internal Medicine (14th ed.) Companion Handbook, McGraw-Hill, NY, 1998.
57.
Tyler KL. Prognosis of acute viral encephalitis. In: Gilchrist JM (Ed). Prognosis in Neurology. Butterworth-Heinemann, Boston,1998:233-238.
58.
Tyler KL, Encephalitis. In Adelman G., Smith BH (Eds.). Encyclopedia of Neuroscience (2nd ed.) Elsevier, Amsterdam, 1999:646-649.
59.
Anderson CA, Tyler KL. Meningitis. In: Adelman G, Smith B (Eds.). Encyclopedia of Neuroscience (2nd edition), Elsevier Science, Amsterdam, 1999:1145-1148.
60.
Tyler KL, Pathogenesis. In: Granoff A, Webster RG (Eds.). Encyclopedia of Virology (2nd ed.), Academic Press, London, 1999:1175-1184.
61.
Tyler KL, Reovirus: General features. In: Webster RG, Granoff A (Eds.). Encyclopedia of Virology (2nd ed.), Academic Press, London,1999:1454-1464.
62.
Tyler KL. Prion diseases of the central nervous system. In: Swartz MN, Remington JS (Eds.). Current Clinical Topics in Infectious Disease (19th ed.), Blackwell Science, Malden,
36
MA 1999:226-251. 63.
Dermody TS, Tyler KL. Introduction to viruses and viral diseases. In: Mandell GL, Bennett JE, Dolin R (Eds.) Principles and Practice of Infectious Diseases (5th ed.), Churchill Livingstone, Philadelphia, 2000:1536-1552.
64.
Tyler KL. Prions and prion diseases of the central nervous system (Transmissible neurodegenerative diseases). In: Mandell GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (5th ed.), Churchill Livingstone, Philadelphia, 2000:19711985.
65.
Corboy JR, Tyler KL. Neurovirology. In: Bradley WG, Daroff RB, Fenichel GM, Marsden CD (Eds.). Neurology in Clinical practice (3rd edition), Butterworth-Heinemann, Boston 2000:823-840.
66.
Debiasi R, Tyler KL. Recurrent aseptic meningitis. In: Davis LE, Kennedy PGE (Eds.). Infectious diseases of the nervous system, Butterworth Heinemann, Oxford England, 2000:445-479.
67.
Tyler KL. Diseases of the central nervous system caused by prions-I. In Rose BD (Ed.). UpToDate, [Infectious Disease Section, M. Hirsch, Ed.] (CD-ROM). Up To Date Inc., Wellesley, MA. 2000 [Updates 2001-2006]
68.
Tyler KL. Diseases of the central nervous system caused by prions-II. In Rose BD (Ed.). UpToDate, [Infectious Disease Section, M. Hirsch, Ed.] (CD-ROM). Up To Date Inc., Wellesley, MA. 2000 [Updates 2001-2006].
69.
Tyler KL. Prions. In Rose BD (Ed.). UpToDate, [Infectious Disease Section, M. Hirsch, Ed.] (CD-ROM). Up To Date Inc., Wellesley, MA. 2000 [Updates 2001-2006].
70.
Roos KL, Tyler KL. Bacterial meningitis and other suppurative infections. In: Braunwald E, Fauci AS, Kasper DL, Hauser SI, Longo DI, Jameson JL (Eds.). Harrison’s Principles of Internal Medicine (15th edition). McGraw-Hill, NY:2001:2462-2471.
71.
Tyler KL. Viral meningitis and encephalitis. In: Braunwald E, Fauci AS, Kasper DL, Hauser SI, Longo DI, Jameson JL (Eds.). Harrison’s Principles of Internal Medicine (15th edition). McGraw-Hill, NY:2001:2471-2481.
72.
Tyler KL, Nathanson N. Pathogenesis of viral infections. In: Knipe DM, Howley PM, et al. (Eds.) Fields Virology (4th edition), Lippincott-Williams & Wilkins, Philadelphia, 2001: 199-243.
73.
Tyler KL. Mammalian Reoviruses. In: Knipe DM, Howley PM, et al. (Eds.) Fields Virology (4th edition), Lippincott-Williams & Wilkins, Philadelphia , 2001:1729-1745.
37
74.
Tyler KL, Pathogenesis of viral infections. In: Knipe DM, Howley PM (Eds.). Fundamental Virology (4th edition), Lippincott-William & Wilkins, Philadelphia, 2001:199-243. [republication of #72]
75.
DeBiasi R, Tyler KL. Viral meningitis and encephalitis. Infectious Disease, Continuum 8: 59-87, 2002 (American Academy of Neurology, published by Lippincott Williams & Wilkins, Philadelphia).
76.
Malessa R, Tyler KL. Acute viral infections of the nervous system. In: Brandt T, Caplan LR, Dichgans J, Diener HC, Kennard C (Eds.). Neurological disorders: Course and treatment, 2nd edition. Academic Press, Amsterdam, 2003:601-613.
77.
DeBiasi RL, Tyler KL. Infections of the nervous system. Viral infections. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J (Eds.). Neurology in Clinical practice (4th edition), Butterworth-Heinemann, Philadelphia, 2004:1515-1543.
78.
Corboy JR, Tyler KL. Neurovirology. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J (Eds.). Neurology in Clinical practice (4th edition), Butterworth-Heinemann, Philadelphia, 2004:831-848.
79.
Tyler KL. Acute viral myelitis. In: Scheld M, Whitley RJ, Marra CM. Infections of the central nervous system (3rd edition). Lippincott William & Wilkins, Philadelphia, 2004:305-322.
80.
Anderson CA, Tyler KL. Meningitis. In: Adelman G, Smith BH (Eds.): Encyclopedia of Neuroscience, 3rd edition (CD-ROM), Elsevier, 2004.
81.
Tyler KL. Meningitis. In: Adelman G, Smith BH (Eds): Encyclopedia of Neuroscience, 3rd edition (CD-ROM), Elsevier, 2004.
82.
Roos K, Tyler KL. Meningitis, encephalitis, brain abscess and empyema. Chapter 360. In: Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL (Eds). Harrison’s Principles of Internal Medicine (16th edition). McGraw Hill, Boston, 2005:2471-2490.
83.
Dermody TS, Tyler KL. Introduction to viruses and viral diseases. In: Mandell GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (6th ed.), Churchill Livingstone, Philadelphia, 2005:1729-1742.
84.
Tyler KL. Prions and prion diseases of the central nervous system (Transmissible neurodegenerative diseases). In: Mandell GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (6th ed.), Churchill Livingstone, Philadelphia, 2005:22192235.
85.
Tyler KL, Anderson CA. Biology and genetics of prions. UpToDate. (CD-ROM) Ver 13.2, 2005. (see also 67-69 for earlier editions)
38
86.
Tyler KL, Anderson CA. Diseases of the nervous system caused by prions. UpToDate (CD-ROM), Ver 13.2, 2005. (see also 67-9 for earlier versions)
87.
Tyler KL, Anderson CA. Creutzfeldt-Jakob Disease. UpToDate (CD-ROM), Ver 13.2, 2005 (see also #67-9 for earlier versions)
88.
Tyler KL, Anderson CA. Variant Creutzfeldt-Jakob Disease. UpToDate (CD-ROM), Ver 13.2, 2005 (see also #67-9 for earlier versions)
89.
Nathanson N, Tyler KL. Pathogenesis of Viral Infections. In: Collier L (Ed.). Topley & Wilson's Microbiology and Microbial Infections (10th ed.), Vol. I: Virology; Mahy BWJ, ter Meulen V (Eds.). Hodder Arnold & ASM Press, London, 2005:236-269.
90.
Gilden DH, Tyler KL. Herpesvirus infection and peripheral neuropathy. In: Dyck PJ, Thomas PK (Eds.). Peripheral neuropathy (4th edition), Elsevier Saunders, Philadelphia, 2005:2117-2127.
91.
DeBiasi R, Tyler KL. Viral meningitis and encephalitis. In: Infectious Disease, Continuum (American Academy of Neurology, published by Lippincott Williams & Wilkins, Philadelphia), 12(2): 58-94, 2006.
92.
Roos KL, Tyler KL. Meningitis, encephalitis, brain abscess, and empyema. In: Hauser SL (Ed.): Harrison’s Neurology in Clinical Medicine. McGraw-Hill, NY, 2006:423-455. (updated reprinting of #82)
93.
Brown HG, Lee JM, Tyler KL, Anderson CA. Creutzfeldt-Jakob Disease. In: UpToDate (CD-ROM), Ver 14.2, 2006. (see #67-9, 85-8 for earlier versions)
94.
Brown HG, Lee JM, Tyler KL, Anderson CA. Variant Creutzfeldt-Jakob Disease. In: UpToDate (CD-ROM), Ver 14.2, 2006. (see #67-9, 85-8 for earlier versions)
95.
Brown HG, Lee JM, Tyler KL, Anderson CA. Diseases of the central nervous system caused by prions. In: UpToDate (CD-ROM), Ver 14.2, 2006. (see #67-9, 85-8 for earlier versions)
96.
Brown HG, Lee JM, Tyler KL, Anderson CA. biology and genetics of prions. In: UpToDate (CD-ROM), Ver 14.2, 2006. (see #67-9, 85-8 for earlier versions)
97.
Anderson CA, Tyler KL. Prion diseases. Chapter 56, In: Engleberg NC, DiRita V, Dermody TS (Eds.): Schaechter’s Mechanisms of Microbial Disease, 4th edition, Lippincott William & Wilkins, Philadelphia, 2007:534-540.
98.
DeBiasi RL, Tyler KL. Infections of the central nervous system. Chapter 61, In: Engleberg NC, DiRita V, Dermody TS (Eds.): Schaechter’s Mechanisms of Microbial Disease, 4th edition, Lippincott William & Wilkins, Philadelphia, 2007:588-602.
39
99.
Schiff LA, Nibert M, Tyler KL. Orthoreoviruses and their replication. In: Knipe DM, Howley PM (Eds.): Fields’ Virology (5th edition), Lippincott William & Wilkins, Philadelphia, 2007:1853-1915.
100. Solbrig MV, Tyler KL. Infections of the nervous system: Viral infections (Chapter 57B). In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J. (Eds.): Neurology in Clinical Practice, 5th edition, Butterworth-Heinemann Elsevier, Philadelphia, 2008:1457-1488. 101. Roos K, Tyler KL. Meningitis, encephalitis, brain abscess and empyema. In Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J (Editors): Harrison’s principles of internal medicine (17th edition), McGraw Hill, NY, 2008:26212641. 102. Tyler KL, Gilden DH. Clinical management of viral encephalitis (Chapter 19). In: Reiss C (Ed.). Neurotropic viral infections. Cambridge University Press, 2008:347-361. 103. Beckham JD, Tyler KL. Clinical manifestations of neurological disease. In: Diamond M (Ed.): West Nile encephalitis virus infection: pathogenesis and the host immune response. Springer, NY, 2009:69-95. 104. DeBiasi R, Tyler KL. Orthoreoviruses and orbiviruses. In: Mandell GL, Bennett JE, Dolin R (Eds): Principles and practice of infectious diseases (7th ed). Elsevier, NY, 2009:2097-99. 105. DeBiasi R, Tyler KL. Coltiviruses and seadornaviruses (Colorado Tick Fever). In: Mandell GL, Bennett JE, Dolin R (Eds): Principles and practice of infectious diseases (7th ed). Elsevier, NY, 2009:2101-3. 106. Bosque P, Tyler KL. Prions and prion diseases of the nervous system (Transmissible neurodegenerative diseases) In: Mandell GL, Bennett JE, Dolin R (Eds): Principles and practice of infectious diseases (7th ed). Elsevier, NY, 2009:2423-2438. 107. Beckham JD, Tyler KL. Encephalitis. In: Mandell GL, Bennett JE, Dolin R (Eds): Principles and practice of infectious diseases (7th ed). Elsevier, NY, 2009:1243-1263. 108.
Roos KL, Tyler KL. Meningitis, encephalitis, brain abscess and empyema. In: Hauser SL (Ed). Harrison’s Neurology in Clinical Medicine (2nd edition). McGraw Hill, NY, 2010: 451-483. In: Kasper DL, Fauci AS. Harrison’s Infectious Disease. McGraw Hill, NY, 2010: 303332
109. Kleinschmidt-DeMasters BK, Tyler KL. Infections and Inflammatory Disorders. In: Perry A and Brat DJ (Eds). Practical surgical neuropathology: A diagnostic approach. Churchill Livingstone Elsevier, NY, 2010:455-484.
40
110. Beckham JD, Solbrig ML, Tyler KL. Viral encephalitis and meningitis. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J (Eds): Neurology in Clinical Practice (6th edition), Elsevier, Philadelphia, 2010. 111. Roos K, Tyler KL. Meningitis, encephalitis, brain abscess and empyema (Chapter 381). In Longo D, Fauci AS, Kasper D, Hauser S, Jameson JL, Loscalzo J (Editors): Harrison’s principles of internal medicine (18th edition), McGraw Hill, NY, 2011:3410-34. 112. Anderson CA, Tyler KL. Prion disease (Chapter 56), In: Engleberg NC, DiRita V, Dermody TS (Eds): Mechanisms of microbial disease (5th edition). Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia, 2013: 552-559. 113. DeBiasi R, Tyler KL. Infections of the central nervous system (Chapter 61). In: Engleberg NC, DiRita V, Dermody TS (Eds): Mechanisms of microbial disease (5th edition). Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia, 2013: 612-627. 114. Oyer R, Beckham JD, Tyler KL. West Nile and St. Louis encephalitis viruses (Chapter 20). In: Tselis AC and Booss J (Vol. Eds.) Neurovirology, Handbook of Clinical Neurology (vol. 123, 3rd series) (Aminoff MJ, Boller F, Swaab DF Series Editors), Elsevier, Edinburgh, 2014:433-447. [PMCID24722324]. 115. Roos K, Tyler KL. Meningitis, encephalitis, brain abscess and empyema (Chapter 164). In Kasper D, Fauci AS, Hauser S, Longo D, Jameson JL, Loscalzo J (Editors): Harrison’s principles of internal medicine (19th edition), McGraw Hill, NY. 2015:883-906. 116. Beckham JD, Tyler KL. Encephalitis (Chapter 91). In: Bennett JE, Dolin R, Blaser M (Eds): Principles and practice of infectious diseases (8th edition), Elsevier, Philadelphia, 2015:1144-1163. 117. Debiasi RL, Tyler KL. Orthoreoviruses and orbiviruses (Chapter 150). In: Bennett JE, Dolin R, Blaser M (Eds): Principles and practice of infectious diseases (8th edition), Elsevier, Philadelphia, 2015:1848-50. 118. Debiasi RL, Tyler KL. Coltiviruses and Seadornaviruses (Chapter 151). In: Bennett JE, Dolin R, Blaser M (Eds): Principles and practice of infectious diseases (8th edition), Churchill Livingstone (Elsevier), Philadelphia, 2015:1851-3. 119. Bosque PJ, Tyler KL., Prion and prion diseases of the ventral nervous system (Transmissible neurodegenerative diseases)(Chapter 181), In: Bennett JE, Dolin R, Blaser M (Eds): Principles and practice of infectious diseases (8th edition), Elsevier, Philadelphia, 2015:2142-53.
IV. Books 1.
Tyler KL, Martin JB (Eds). Infectious Diseases of the Central Nervous
41
System. Contemporary Neurology Series 41. FA Davis, Philadelphia, 1993. 2.
Tyler KL, Oldstone MBA (Eds). Reoviruses I: Structure, Proteins and Genetics. . Current Topics in Microbiology & Immunology Vol. 233/1, Springer-Verlag, Heidelberg, 1998.
3.
Tyler KL, Oldstone MBA (Eds.). Reoviruses II: Cytopathogenicity and Pathogenesis. Current Topics in Microbiology and Immunology. Vol. 233/2, Springer-Verlag, Heidelberg, 1998.
4.
Tyler KL. Associate Editor, Aminoff MJ, Daroff RB (Editors): Encyclopedia of the Neurological Sciences, Academic Press, Amsterdam, 2003.
5.
Finger S, Boller F, Tyler KL (Eds). History of Neurology. Handbook of Clinical Neurology, vol. 95, 3rd Series (Aminoff MJ, Boller F, Swaab DF Series Editors). Elsevier, Amsterdam, 2010.
V. Editorials & Commentaries 1.
Tyler KL. Prions [editorial] Infections in Medicine 11:382-383, 1994.
2.
Tyler KL, Diagnosis of herpes simplex encephalitis: Application of polymerase chain reaction to cerebrospinal fluid from brain-biopsied patients and correlation with disease. [commentary] Neurology Network Commentary 1:9-13, 1997.
3.
Tyler KL, Cerebrospinal-fluid polymerase chain reaction and the diagnosis of viral infections of the central nervous system. [commentary] Neurology Network Commentary 1:276-282, 1997.
4.
Tyler KL, Rabies [commentary]. Neurology Network Commentary 3:64-67, 1999.
5.
Tyler KL. Viruses in Amyotrophic Lateral Sclerosis. [commentary] Lancet Neurology Network 4:1, 2001 (e-published at www.lancetneuronet.com).
6.
Tyler KL. West Nile Virus encephalitis in America . [editorial] N Engl J Med 344: 18581859, 2001.
7.
Tyler KL, McArthur JC. Through a glass darkly: The role of CSF viral load (HIV-1 RNA) measurements in understanding the pathogenesis of HIV infection of the CNS. [editorial]. Arch Neurol 59:909-912, 2002.
8.
Tyler KL. Creutzfeldt-Jakob Disease [editorial perspective]. N Engl J Med. 348: 681-682, 2003.
9.
Tyler KL. Human herpesvirus 6 and multiple sclerosis [editorial]. J Infect Dis. 187:1360-
42
1364, 2003. 10.
Tyler KL. The uninvited guest. JC virus infection of neurons in PML [editorial]. Neurology 61:734-735, 2003.
11.
Tyler KL. Commentary: Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC. Oral transmission of Kuru, Creutzfeldt-Jakob disease, and scrapie to non-human primates. J Infect Dis 1980; 142:205-208. [Centennial Perspective]. J Infect Dis 190:653-660, 2004.
12.
Davis LE, Tyler KL. Molecular diagnosis of CNS viral infections. [editorial commentary]. Journal of Neurology, Neurosurgery, and Psychiatry 76:10, 2005. [PMC1739295]
13.
Tyler KL. Rabies in four organ transplant recipients [article commentary]. Journal Watch Neurology (from the publishers of the N Engl J Med) 7:55, 2005.
14.
Gilden DH, Tyler KL. Bell’s palsy- Is glucocorticoid treatment enough ? [editorial]. N. Engl. J. Med. 357:1653-5, 2007.
15.
Tyler KL. Bacterial meningitis: An urgent need for further research to reduce mortality and morbidity [editorial]. Neurology 70:2095-6, 2008.
16.
Bosque PJ, Tyler KL. Prions’ travels-Feces and transmission of prion diseases. [editorial] J. Infect. Dis. 198:8-9. 2008.
17.
Tyler KL. Cortical demyelination in MS and progressive multifocal leukoencephalopathy [article commentary]. Journal Watch Neurology (from publishers of the N Engl J Med) 10:51, 2008.
18.
Tyler KL. PML’s 50th birthday- New insights into pathogenesis [editorial]. Annals Neurol. 64:359-61, 2008.
19.
Tyler KL. Progressive Multifocal Leukoencephalopathy: Can we reduce risk in patients receiving biological immunomodulatory therapies? [editorial] Annals Neurol. 68: 271-274, 2010. Tyler KL. PML therapy: “It’s Déjà vu all over again” [editorial]. J. Neurovirol. 19:311313, 2013.
20.
21.
Steiner I, Tyler KL. The toll (like receptor 3) to the pathogenesis of herpes simplex encephalitis [editorial]. Neurology 83:1882-3, 2014.
22.
Tyler KL. Fingolimod and risk of varicella-zoster virus infection: Back to the future with an old infection and a new drug.[editorial]. JAMA Neurol. 72:10-13, 2015
23.
Tyler KL. Rationale for the evaluation of fluoxetine in the treatment of enterovirus-D68associated acute flaccid myelitis [viewpoint] JAMA Neurol 72:493-4, 2015.
43
24.
Tyler KL. Failure of adjunctive valacyclovir to improve outcomes in Herpes Simplex encephalitis. Clin Infect Dis (epub ahead of print). PMID 25956893
VI. Other Products of Scholarship (Audio cassette recordings, Book reviews, Obituaries) 1.
Tyler KL. Lawrence C McHenry Jr (1929-1985).[Obituary] Archives Neurology 42:1202-1203, 1985.
2.
Tyler KL. Therapy of viral diseases of the central nervous system.[Audio cassette recording]. Clinical Neuroscience Review (Stanley H. Appel, editor), #307, 1985.
3.
Tyler KL. Molecular basis of viral neurovirulence. [Audio cassette recording] Clinical Neuroscience Review (Stanley H. Appel, editor), #604, 1986.
4.
Tyler KL. An Early History of Craniotomy: From Antiquity to the Napoleonic Era by L Bakay. [book review] Neurology 36:1013-1014, 1986.
5.
Tyler KL. Founders of Child Neurology, Ashwal S (Ed.). [book review] Annals Neurology 30:856, 1991.
6.
Tyler KL. Molecular Neurovirology, Roos R (Ed). [book review] J. Neurol. Sci. 118:223, 1993.
7.
Tyler KL, Viral Infections of the Nervous System (2nd ed.), Johnson RT, [book review] Annals Neurology 45:549, 1999.
8.
Tyler KL, [book review]. Segmented double-stranded RNA viruses:structure and molecular biology. Paton JT (Ed.) [book review] Lancet Infectious Disease, 8:224, 2008.
VII. Published Syllabi: 1.
Tyler KL, Neuroanatomy, neurophysiology, and neuropathology in 19th century France. History of Neurology (Course #231, K.L. Tyler, Director), American Academy of Neurology, Chicago, 1989.
2.
Tyler KL, Introduction to the history of neurology in the 18th and early 19th centuries. History of Neurology (Course #425, K.L. Tyler, Director), American Academy of Neurology, Miami Beach, 1990.
3.
Tyler KL, Diagnosis of aseptic meningitis and encephalitis. Infections of the Nervous System (Course #246, R.T. Johnson, Director), American Academy of Neurology, Boston, 1991
4.
Tyler KL, Introduction to the history of neurology in the 18th century and early 19th centuries. History of Neurology (Course #220, K.L. Tyler, Director), American Academy
44
of Neurology, Boston, 1991. 5
Tyler KL, The recurrent meningitis syndrome. Infections of the Nervous System I (Course #121, P. Coyle, Director), American Academy of Neurology, Seattle, 1995.
6.
Tyler KL, Treatment of acute herpes virus infections of the nervous system. Therapy in Neurology I (Course #126, A.E. Miller, Director), American Academy of Neurology, Seattle, 1995.
7.
Tyler KL, Viral meningitis and encephalitis. Infections of the Nervous System I (Course #223, C. Marra, Director), American Academy of Neurology, Boston, 1997.
8.
Tyler KL, Neurology in Boston: From the Winthrop Fleet (1630) to the mid-19th Century. Bostonian Neurological History Revisited (Course #365, S. Mishra, Director), American Academy of Neurology, Boston, 1997.
9.
Tyler KL, Intracranial subdural empyema and epidural abscess. Infections of the Nervous System I (Course #7FC006, C. Marra, Director), American Academy of Neurology, Minneapolis, 1998.
10.
Tyler KL, William Alexander Hammond (1828-1900). Origins of American Neurology (Course #3PC.008, E. Pappert, Director), American Academy of Neurology, Minneapolis, 1998.
11.
Tyler KL, Silas Weir Mitchell (1829-1914). Origins of American Neurology (Course #3PC.008, E. Pappert, Director), American Academy of Neurology, Minneapolis, 1998.
12.
Tyler KL, Herpes simplex virus infections of the nervous system. Infections in the Nervous System. (Course #3FC.004, C. Marra, Director), American Academy of Neurology, Minneapolis, 1999.
13.
Tyler KL, William Richard Gowers (1845-1915). Masters of Neurology: The 19th Century. (Course #4PC.003, E. Pappert, Director), American Academy of Neurology, Minneapolis, 1999.
14.
Tyler KL, Clash of the Titans: The Goltz-Ferrier debates and the triumph of cerebral localizationist theory. Clash of the Titans: The Great Debates of 19th Century Neurology (Course #5PC.002, E. Louis, Director), American Academy of Neurology, San Diego, 2000.
15.
Tyler KL, Bacterial Brain Abscess. Infections of the Nervous System (Course #2FC.004, C. Marra, Director), American Academy of Neurology, San Diego, 2000.
16.
Tyler KL. Recurrent Viral Meningitis and Chronic Viral Encephalitis. Neurovirology (Course #3AC.005, R. Johnson, Director), American Academy of Neurology, Denver, 2002.
45
17.
Tyler KL. Acute Viral Encephalitis. Infections of the Nervous System (Course #7FC.003, K. Roos, Director), American Academy of Neurology, Denver, 2002.
18.
Tyler KL, William Richard Gowers (1845-1915). An evening with great books from the AAN history of neurology archives (Course #2DS.005, K.L. Tyler, director), American Academy of Neurology, Denver, 2002.
19.
Tyler KL. Update on Herpes simplex virus encephalitis. Neurovirology (Course #7PC.006, K. Tyler, Director), American Academy of Neurology, Honolulu, 2003.
20.
Tyler KL, Acute viral encephalitis. Infections of the Nervous System (3FC.002, K. Roos, Director), American Academy of Neurology, San Francisco, 2004.
21.
Tyler KL, Unusual manifestations of infectious diseases. Unusual manifestations of infectious diseases (Course #3AS.008, J. Berger, Director), American Academy of Neurology, San Francisco, 2004.
22.
Tyler KL, Seminal cases in frontal lobe function: The American crowbar case. Seminal Cases in the History of Neurology (Course #4PC.003, V. Henderson, Director, American Academy of Neurology, Miami Beach, 2005)
23.
Tyler KL, West Nile virus. The Neurological complications of emerging infections and bioterrorism. (Course #4BS.002, J. Berger, Director, American Academy of Neurology, Miami Beach, 2005).
24.
Tyler KL, Nipah and Hendra viruses. The Neurological complications of emerging infections and bioterrorism. (Course #4BS.002, J. Berger, Director, American Academy of Neurology, Miami Beach, 2005).
25.
Tyler KL, Nipah and Hendra Viruses. Neurological Complications of emerging infections and bioterrorism. (Course #3DS.007, J. Berger, Director, American Academy of Neurology, San Diego, 2006).
26.
Tyler KL, West Nile virus. Neurological Complications of emerging infections and bioterrorism. (Course #3DS.007, J. Berger, Director, American Academy of Neurology, San Diego, 2006).
27.
Tyler KL, Acute viral encephalitis. Infections of the nervous system. (Course #7FC.005, A. Aksamit, Director, American Academy of Neurology, San Diego, 2006).
28.
Tyler KL, West Nile virus. Neurological Complications of emerging infections and bioterrorism. (Course #3DS.005, J. Berger, Director, American Academy of Neurology, Boston, 2007).
29.
Tyler KL, Japanese encephalitis. Neurological Complications of emerging infections and bioterrorism. (Course #3DS.005, J. Berger, Director, American Academy of Neurology, Boston, 2007).
46
30.
Tyler KL, West Nile virus. Infections of the nervous system. (Course #7FC.003, R. Bartt, Director, American Academy of Neurology, Chicago, 2008).
31.
Tyler KL. Acute viral encephalitis. (Course #3FC.002, S. Fahn, Director, American Academy of Neurology, Toronto, 2010).
47
32.
33.
Tyler KL. Acute viral encephalitis. (Course #3FC.006, R. Bartt Director, American Academy of Neurology, Honolulu, 2011). CDC. Acute flaccid myelitis: interim considerations for clinical management. Centers for Disease Control (CDC)(posted 7 November, 2014; http://www.cdc.gov/ncird/downloads/acute-flaccid-myelitis.pdf) Participants: Abzug M, Jackson M, Byington C, Clark R, Dominguez S, Glaser C, Jackson M, Larsen G, Laughlin C, Modlin J, Messacar K, Sawyer M, Schreiner T, Simon D, Tyler KL, van Haren K, Waubant E, Wizniter M. CDC Participants: Sejvar J, Pastula D, Cortese M, Feiken D, Leshan E, Oberste S, Pallansch M, Seward J.
