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DIAZINON 1. Exposure Data
1.1.2 Structural and molecular formulae, and relative molecular mass
1.1 Identification of the agent 1.1.1 Nomenclature
N
Chem. Abstr. Serv. Reg. No.: 333-41-5 Chem. Abstr. Serv. Name: O,O-diethyl O-[6methyl-2-(1-methylethyl)-4-pyrimidinyl] phosphorothioate Preferred IUPAC Name: O,O-diethyl O-[6methyl-2-(propan-2-yl)pyrimidin-4-yl] phosphorothioate Synonyms: Bazudine, Diazinon, Dimpylate, Neocidol, Neotsidol Trade Names: Diazinon products have been sold in various countries under numerous trade names, including, for example, Basudin; Cekuzinon; Dianon; Diazol; Dragon; Kayazinon; Knox Out; Neocidol; Spectracide; Terminator (Farm Chemicals International, 2014; NCBI, 2015)
O O
P O
N
S
Molecular formula: C12H21N2O3PS Relative molecular mass: 304.35 Additional chemical structure information is available in the PubChem Compound database (NCBI, 2015).
1.1.3 Chemical and physical properties of the pure substance Description: The pure form is a colourless oily liquid. The technical grade is light amber to dark brown in colour, and the insecticide formulation is a colourless liquid with a faint ester-like odour (NIOSH, 2010; NCBI, 2015). Solubility: Slightly soluble in water at 60 mg/L (NCBI, 2015) at 20 °C. Completely miscible with common organic solvents, e.g. ethers, alcohols, benzene, toluene, hexane, cyclohexane, dichloromethane, acetone, petroleum oils (NCBI, 2015) 1
IARC MONOGRAPHS – 112 Volatility: Vapour pressure, 9.01 × 10−5 mm Hg (25 °C); low vapour pressure suggests that little volatilization from soil would be expected (NCBI, 2015). Stability: More stable in alkaline formulations than at neutral or acid pH (NCBI, 2015) Reactivity: Susceptible to oxidation above 100 °C (Tomlin, 2000) Octanol/water partition coefficient (P): log Kow 3.81 (NCBI, 2015) Henry’s law: 1.13 × 10–7 atm m3 mol–1; the low Henry’s law constant suggests that little volatilization from water surfaces would be expected (NCBI, 2015). Conversion factor: Assuming normal temperature (25 °C) and pressure (101 kPa), mg/m3 = 12.4 × ppm.
2000–3000 tonnes in 2001 (diazinon was ranked third among organophosphate insecticides) to
