Talent Times - Agency for Science, Technology and Research (A*STAR)

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stay informed of potential opportunities, especially those that interest you. Switching from the lab to a career outside
VOLUME 7

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A Publication of Agency for Science, Technology and Research

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A*STAR and Industry

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contents 02 MAKING AN IMPACT BEYOND THE LAB

VOLUME 7

Talent Times

04 PASSIONATE ABOUT BEING THE WORLD’S FIRST

06 DEDICATION TO THE FIGHT AGAINST DISEASE

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08 ADVANCING THE AI WORK

10 The Agency for Science, Technology and Research (A*STAR) is Singapore’s lead public sector agency that spearheads mission-oriented research. Beyond developing cutting-edge technology and fostering talent, we drive innovation by promoting collaborations between our researchers and industry. We help industry partners position themselves competitively for the future and assist local enterprises to evolve and grow in a fast-changing economy, while providing support to aspiring entrepreneurs. In this issue of Talent Times, we shine the spotlight on talents who work with industry partners to advance capabilities and those who have become entrepreneurs spinning off their own companies as a result of research developments. With varying interests and personalities, our pool of diverse talent share a common goal − to impact lives through science and together build a better future. Read on to find out more about their inspiring journeys!

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Talent Times Vol. 7

A*STAR and Industry

TEEING UP THE ENTREPRENEURIAL SPIRIT

12 NURTURING TOMORROW’S TALENT

MAKING AN IMPACT BEYOND THE LAB DR HO WEN QI Associate, Lightstone Singapore Pte Ltd

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rom a young age, Dr Ho Wen Qi knew that science was her calling. Her passion eventually led her from the classroom to the lab to the corporate world – all made possible by the A*STAR National Science Scholarship. “It provided me with a great opportunity to pursue my interests in biomedical research.”

various industry project leads gave her a first-hand glimpse into the alternative paths beyond academic science and sparked a strong appreciation of what scientific training can achieve. “I realised that there are opportunities to apply what I’ve learned from my scientific training to careers outside of academia.”

Upon graduating from Stanford University, she joined the A*STAR Singapore Immunology Network (SIgN) as a Research Fellow where she delved into allergies and asthma while fronting public education programmes, exhibitions and other events.

With her desire to enrich her experiences beyond labs and contribute to Singapore’s life science ecosystem, she leapt at the chance for a secondment to Lightstone Singapore, which invests in early stage life science start-ups. Since November 2015, she has been elbow-deep in exploring potential

Her interactions with fellow scientists, clinicians and

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WEN QI’S TIPS FOR EXPLORING CAREER OPTIONS BEYOND THE LAB

Network with people outside of academia by building new relationships with people in the fields you are interested in.

Gain experience outside the lab, whether through secondments, fellowships or simply volunteering your time.

investments, identifying commercial opportunities from academic science and networking with the movers and shakers in Singapore’s life sciences circle, from government agencies and private companies to innovative scientists, entrepreneurs and investors. “No two days are the same!” she exclaims. “The scientific training and critical thinking skills I’ve gained through my postdoctorate at A*STAR have been extremely helpful in assessing the life sciences technologies we come across.” Still, making the jump has had its challenges.

“A big part of assessing the commercial viability of a technology is in the business strategy, many aspects of which I’m still picking up.” much excited about her new ventures in life sciences and fulfilling her personal goals with her secondment. “I hope to facilitate the translation of an idea to a commercial product that will have a positive impact on human health and the Singapore life science eco-system.”

“Coming from academic science, I lack business experience,” she admits. “A big part of assessing the commercial viability of a technology is in the business strategy, many aspects of which I’m still picking up.” With an eye firmly fixed on the prize, Wen Qi is staying level-headed in the game, though very

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Cast your net wide and stay informed of potential opportunities, especially those that interest you.

Switching from the lab to a career outside of academia can be a daunting experience. Have the courage and tenacity to pursue the opportunities that come your way.

PASSIONATE ABOUT BEING THE WORLD’S FIRST DR LIM XINHONG Principal Investigator, Institute of Medical Biology

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s a Principal Investigator at A*STAR’s Institute of Medical Biology (IMB), Dr Lim Xinhong’s work takes him deep into the realm of molecular biology, where he endeavours to save the world one skin ailment at a time. “In our lab, we seek to understand and alleviate common skin problems like hair loss and acne,” said Xinhong, whose ground-breaking research on skin stem cells saw him garnering the prestigious Young Scientist Award last year. By analysing how skin stem cells behaviours may be imbalanced in such cases, he and his team work closely with academic and industry partners for new ways to control them.

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SKIN AND HAIR CARE APPLICATIONS OF MOLECULAR BIOLOGY

“In our lab, we seek to understand and alleviate common skin problems like hair loss and acne.” “We’re making good progress developing novel models that are biologically accurate for acne and sebum production, that could be used to identify better skincare products!” he explains. “As far as we know, we’re one of the first in the world to develop some of these models and that is very exciting for me personally.”

the opportunity to enrol in the Stanford Graduate School of Business’s Program in Innovation and Entrepreneurship, now known as Ignite. He pitched an idea for an app company, formed a team around it and built the business over several months, even pitching to Silicon Valley’s venture capitalists.

While being very passionate about his work, Xinhong recognises the importance of anchoring research to reality. His journey in science and his path at A*STAR has taken him outside the lab and given him the experience to take on different roles as inventor, entrepreneur and investor.

Apart from this, he interned with A*STAR’s commercialisation arm, ETPL, where he gained new insights into moving discoveries from the lab to the market, from patenting to intellectual property (IP) strategy.

It all began when he accepted an A*STAR National Science Scholarship, which led him to his Bachelor of Science and later to the Stanford University School of Medicine for his PhD. There, he had

The knowledge gleaned from his experiences continues to shape his research efforts today. “My experiences have taught me to think of my work beyond the science, into how the work might be translated to the clinic and market. I understand what might be most attractive to the market, and can strengthen our products to draw investors.” With a potentially viable skincare line well in the works, Xinhong is hopeful that his research efforts will translate and sell well in the real world with A*STAR’s support. “A*STAR is supportive of venture formation, and there are many people we can turn to in the organisation for help with the process.”

A stem cell producing keratinised daughter cells (in green) that fill up the epidermis, the outermost layer of skin. The blue portions represent the nucleus of the cells. Lim Xinhong’s lab has developed methods to visualise these stem cells (bottom of image, in green) and the signals that control them with unprecedented resolution, and has used mathematical modelling to understand how they behave in a population to maintain tissue.

He adds, “All in all, I feel like I have a realistic sense of what it takes to build a business. This knowledge and experience will help me a lot in my subsequent entrepreneurial endeavours.” 05

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Molecular biology deals with macromolecules such as proteins and nucleic acids that are essential to life.

This branch of biology investigates how cells develop, operate, communicate with other tissues and organs throughout the body, and control their activities.

Xinhong uses techniques developed in this field to innovate fresh methods for skin and hair care applications.

Scan here to learn more about Xinhong’s work.

DEDICATION TO THE FIGHT AGAINST DISEASE DR ROSEMARY TAN Chief Executive Officer & Founder, Veredus Laboratories

“I believe we are doing something meaningful. It’s not a glamourous job, with lots of hard work and hard decisions.”

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person driven by her convictions and dedication to science. That, in a nutshell, sums up Dr Rosemary Tan, CEO of Veredus Laboratories, a medical device company specialising in portable diagnostic tool kits. The company she founded is one which combines her belief that tools to diagnose diseases should be readily available to all, and one which ignites her passion to prevent the spread of diseases effectively through low-cost, robust and efficient diagnostic tools. Rosemary’s journey began in 1996 when she joined A*STAR’s Institute of Molecular and Cell Biology (IMCB). The one year proved to be a defining one where she learnt three lessons: 1) Create an impact from the work that you do. 2) Love what you do and excel at it. 3) Make friends everywhere you go.

One of the key products from Veredus Laboratories – the VereChipTM is a Lab-on-Chip device.

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TAKING HEALTH AND SAFETY TO THE NEXT LEVEL Veredus Laboratories’ Lab-on-Chip (LOC) devices can detect and identify multiple pathogens in one test. From tuberculosis, flu epidemics and food safety to biological weapons, avian disease and more, the company has developed several practical applications that address health and safety issues with some of the advantages as follows:

Quick: Fast turnaround time

With these takeaways, Rosemary founded Veredus in 2003. Her first commercialised kits were the Malaria and H5N1 PCR tests – both of which tapped A*STAR’s licences in the respective areas. However, the challenge was that such kits require a lot of handson work. Rosemary had a vision for the kit to be multiplexing − an approach that can detect multiple targets or pathogens in a single test – and to work effectively based on a simpler workflow. In her relentless pursuit of perfection, she came across ST Microelectronics’ Lab-on-Chip (LOC) which she felt could solve the challenge. The company was looking for a bio-application partner to design DNA panels on the chip which led to their collaboration in 2006, with ST Microelectronics becoming a major investor in 2011. Three years later, the majority shareholdership changed hands

to Accuron, a wholly owned subsidiary of Temasek Holdings, and Veredus acquired the LOC DNA spotting capability. Today, Veredus continues to fulfil Rosemary’s vision to arrest the spread of disease through cost-effective solutions. The company has several new developments on hand, one of which is a chip that can detect and identify the big six bacteria that contaminate beef produce – thus bridging a gap in food safety. While the entrepreneurship journey has been challenging, Rosemary remains steadfast. “I believe we are doing something meaningful. It’s not a glamourous job, with lots of hard work and hard decisions. I am proud that we are visionary and daring in our approach. At the end of the day, it’s not just a job, but a part of life’s purpose to help humanity.”

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Mobile: Portable for use at areas such as checkpoints and borders

Comprehensive: Tests for multiple pathogens

Easy to use: Simple workflow for use by minimally trained personal

HOW KOOKI’S AI POWERS A BETTER WORLD

Wee Tiong with his co-founder, Ang Tee Wee.

Job Intelligence: Kooki teamed up with an investor to form JobTech. The AI-based job search service studies job advertisements to help jobseekers streamline their search and direct them to quality, authentic jobs.

Media Intelligence: The AI bot gleans social media data from blogs, forums and other portals, analyses them to pick out trends and reflect market sentiment. The results help companies to enhance their product or service portfolio to better meet customer needs.

Customer Intelligence: This sales AI bot chats with customers and analyses their preferences to present various options and guide them toward making a purchase. While the sale still has to be closed by a human, it significantly shortens the sales cycle.

Market Intelligence: Still in its infancy, the AI bot improves and builds a company’s intellectual capital by capturing information from emails, documents and other channels to ensure knowledge is not lost, even if an employee leaves the organisation.

ADVANCING THE AI WORK ANG WEE TIONG Founder & Chief Executive Officer, Kooki Pte Ltd

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hile some may shy away from the thought of a robotpowered world, Ang Wee Tiong remains pragmatic. “Like it or not, machines are here to stay.”

With a background in computer science and astrophysics, the artificial intelligence (AI) researcher spent 10 years at A*STAR’s Institute for Infocomm Research (I2R) where he spearheaded AI research, development and translation. There, he witnessed firsthand commercialisation of research IP and various collaborations with multinational corporations (MNCs) and local small and mediumsized enterprises (SMEs).

Seeing his research applied to real-world problems inspired him to set up his own company in October 2015. Kooki, his brainchild, is a start-up that develops AI to boost the productivity and knowledge retention of enterprise professionals. Since then, it has made headway in four key areas, aiding job seekers (job intelligence), helping companies improve their products and services (media intelligence), driving online sales (customer intelligence) and capturing institutional knowledge (market intelligence). “It’s a whole new world. Research has a logical process, but business also involves a lot of intuition, emotion, courage and luck,” 08

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said Wee Tiong. “It’s not easy to switch mindsets and succumb to the fact that the sum total of the success of your seemingly greatest-ever invention could depend on something as ‘illogical’ as timing and others’ perception.” “As an entrepreneur, the hours are long and you don’t get a break,” he added. Despite the challenges and the steep learning curve, if he could live his life all over again, he says it would without a doubt, be a decision he would make again. “I am really inspired when people benefit from my research and when my research is later used to generate solutions to problems.”

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While he works on making inroads in the corporate sector, Wee Tiong continues his ties with A*STAR. Kooki is currently operating out of A*START Central, a coinnovation space created by A*STAR ETPL to inspire, incubate, develop, train and support technopreneurs and promote the use of A*STAR technologies in building successful start-ups and businesses, with the company tapping on A*STAR’s research IPs. “We have regular meetings with A*STAR. It’s a twoway conversation where we provide feedback on industry needs and A*STAR’s latest research and technologies are shared with start-ups in these areas.”

“It’s a crazy idea. But I have this dream that my kids can talk to a virtual me after I’m gone and I can give them advice.”

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Even though he has a lot on his plate, Wee Tiong has carved out time for a pet project – a transcendence prototype which can transfer knowledge and consciousness into a machine, thus allowing humans to “live forever”. “It’s a crazy idea. But I have this dream that my kids can talk to a virtual me after I’m gone and I can give them advice and guidance.” Dreams do become reality, and Wee Tiong has this advice for fellow dreamers. “In a business, especially a start-up, you have to be someone who can take risks, be flexible and live with adversity and uncertainty. At the end of the day, you just have to do it.”

TEEING UP THE ENTREPRENEURIAL SPIRIT DR ISAKOV DMITRY Principal Investigator, Precision Measurement Group, Singapore Institute of Manufacturing Technology

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rom aerospace to air-conditioning, Dr Isakov Dmitry’s research forges new frontiers with applications that can help develop value to both industries and individuals. After eight years at A*STAR’s Singapore Institute of Manufacturing Technology (SIMTech), the Principal Investigator with the Precision Measurement Group developed an entrepreneurial streak and decided to find new challenges in the world of business. “What made me consider an entrepreneurial adventure was the clear vision that I could help others through more efficient products and stay profitable while doing that.” The urge to step out for a breather away from regular

lab work prompted Isakov to sign up for his first secondment under A*STAR’s T-Up programme. Its Growing Enterprises through Technology Upgrade (GET-Up) programme’s expert secondment scheme, designed to help SMEs through A*STAR’s research community, effectively connected Isakov with a Singapore-based company that designs, fabricates and distributes optical components and systems. “The goal was to help them grow their business and explore possibilities in system development through scientific expertise,” he explains. “On a personal level, I was very interested in understanding the new infrared detection technology which they were introducing into the market.”

His one year stint in 2014 saw him delve into high speed uncooled mid-infrared detectors – a device that the company was distributing – and convert them into a system that they could sell under the company’s brand. With Isakov on board, the team set about exploring different applications and eventually focused on laser welding monitoring. As the device can detect high temperatures, it is able to monitor the welding process with millisecond precision and stop it if something is going wrong. Although his secondment is long over now, Isakov still maintains contact with the company. “We have built a strong relationship. Sometimes

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they will consult me if they encounter issues with other projects and I consult them on which solutions are available in addressing similar issues.” Beyond expanding his expertise in infrared detection technology, the secondment into industry also pushed him in the right direction to fulfil his entrepreneurial dream. Upon his return to A*STAR in 2015, he focused on advancing aerospace technologies for the aerospace industry which he researched earlier, and this led to patent applications filed that same year. Today, he has brought the Technology Relevance Levels of his inventions to standards high enough for industry adoption.

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IDEAS FOR SCIENTISTS PURSUING ENTREPRENEURSHIP For scientists who recognise that their innovations have the potential to be commercialised, Isakov shares his plans on how he would bridge the gap between science and entrepreneurship: 1.

x10 Identify how much profit your technology can potentially bring to a potential customer. If your solution in the foreseeable future does not lead to a profit equivalent to 10 times of your technology cost, it is not a viable solution.

2.

“It may be ambitious, but it’s good to set a target so that I have a goal to focus on.” Both techniques are currently under evaluation by a global aerospace manufacturer and a local company focused on aerospace maintenance, repair and overhaul (MRO). One of these technologies, called Vacuum Assisted Thermography, also received SIMTech’s Best Research Achievement Award in 2015.

of cooling down buildings. To this end, Isakov has received a grant to research his ground-breaking airconditioning idea.

As inspection technologies require high levels of customisation and are demanded in low volumes by customers, these drawbacks make them less viable as a business. Recognising this, Isakov switched gears and focused attention on other areas of research. One of these endeavours is looking at more effective methods

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Today, Isakov is several steps closer to launching his own business. “Depending on how the R&D goes, I’m looking to start my own company as this same technology can be used over multiple platforms. I aim to finish the research in two years,” he says hopefully. “It may be ambitious, but it’s good to set a target so that I have a goal to focus on.”

Talent Times Vol. 7

Talk to potential customers to test your assumptions.

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Learn how to sell your vision − focus on conveying your idea in an easy to understand manner for potential customers, partners, future employees and investors.

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Connect the dots of opportunity that don’t yet exist into a scalable business. You will never know where it may lead you.

NURTURING TOMORROW’S TALENT PROF ALFRED HUAN Former Executive Director, A*STAR Graduate Academy Executive Director, Institute of High Performance Computing Executive Director, Institute of Materials Research and Engineering

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ith a keen focus on nurturing the next generation of scientists and researchers, the A*STAR Graduate Academy (A*GA) offers scholarships, fellowships and collaborative partnerships with universities, to develop young scientific talents to their full potential. We caught up with Prof Alfred Huan on how the organisation hopes to foster an entrepreneurial spirit among its scholars to ready them for a future economy where innovation drives all things forward. What does A*GA do? The major pipeline of A*STAR’s Singaporean talent core starts at A*GA. We recruit from among the brightest in our schools and provide the opportunities for them to be trained and nurtured in the best science and engineering institutions around the world. As they acquire the skills that prepare them to take on the challenges of a research career, we progressively acquaint them with A*STAR’s mission through our research attachment programmes where they work with our researchers to gain first-hand experience. Upon their return, they are well-equipped to take up positions in our Research Institutes (RI) and make their mark in science and technology. Another aspect of A*GA’s work is to increase the diversity of our PhD student population through the Singapore International Graduate Award (SINGA) Programme.

We actively recruit from a spread of undergraduate universities, from South America and Europe to countries in the Far East and Middle East. The different expertise and perspectives resulting from the diversity of backgrounds and training enhances the work of the RIs. In addition, the students help us establish an international network for future collaborations even as they return to their home countries. A*GA also leads the interactions with overseas universities in partnerships for joint PhD training under the A*STAR Research Attachment Programme (ARAP) scheme, and this has proved to be a highly effective scheme for international collaborations. What are some of the challenges and changes that A*GA has gone through over the years? While A*GA has always aimed to create a stream of local scientific talent for A*STAR, it has become clear that a variety of skills will be required for a vibrant innovation ecosystem. The ability to create useful technologies and to take them towards commercialisation or adoption by industry will be valuable. Hence we have been flexible in allowing scholars to gain postdoctoral experience in high tech companies and start-ups, but at the same time, ensuring that they stay relevant to A*STAR’s economic mission. Another challenge comes in the form of maintaining the right level of engagement while the scholars are 12

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pursuing their studies. There are over 900 scholars in various stages of their academic journeys and they are spread over numerous locations, so staying in touch with them is a daunting task. This is especially crucial during the PhD years when the demands of rigorous scientific training can at times leave the scholar feeling isolated and adrift. Hence, efforts are made to meet the scholars through the Connect, Advise, Reach out to and Engage (CARE) Programme Trips. The A*GA officers have invested much time in keeping track of the scholars’ progress, and not surprisingly, they have become friends with the scholars through the rapport that has been built up. This is immensely satisfying and supplies the human touch to an otherwise transactional relationship. To be sure, we can always do more to spot the scholar who needs help, and we encourage scholars to keep a network of friends and to meet up with their mentors once each year.

In today’s context of fast-evolving disruptive technologies, how does A*STAR help nurture an entrepreneurial spirit in scholars? At several university settings in the US and UK, there is a strong spirit of enterprise and of staying relevant. Scholars who are immersed in these highly entrepreneurial setups often return to A*STAR brimming with confidence and energy. They can join existing research groups with welldefined goals or gather with like-minded people to pursue novel ideas. Through our spin-off friendly policies, we encourage them to explore the local ecosystem and learn, to experiment with their ideas and to stretch beyond their usual reach. Further opportunities are available for scholars to intern at ETPL, the commercialisation arm of A*STAR. This can take place during their undergraduate training or just before embarking on their PhD. The learning objectives are twofold: • Assessment of technologies and market opportunities, understanding product development and commercialisation; • Gaining insight on translating tech ideas into businesses and challenges faced by start-ups. Scholars can use these opportunities to gain a better perspective on the impact of their R&D and make more informed decisions on their PhD directions.

Lastly, it is important that we make efforts to grow our local scientific talent base. Improving our outreach to students and inspiring them to take up a career in science has always been a challenge. Science Centre Singapore is one of our key partners who has supported our STEM objectives through activities that arouse the curiosity in students about natural phenomena and events that raise the awareness of the impact of science. These events include the annual Singapore Science Festival and the Singapore Science and Engineering Fair. But by far, the biggest contributions come from our own researchers who expend large amounts of time and effort in mentoring students in projects. They also play an active part in giving talks, outlining their personal journeys and sharing their experiences with the students. What differentiates A*STAR’s scholarships from other science scholarships offered in Singapore? The rich and diverse environment at A*STAR exposes our scholars to a full range of activities, from conducting world-leading scientific research to developing cutting-edge technologies. They can take part in roadmapping exercises and technology scans, or partner with industries on real problems and technology transfer. They get to understand issues on licensing and handling intellectual property, and how collaboration agreements are structured. We strongly encourage them to explore collaborations with other agencies in the R&D ecosystem. Several scholars have started their own companies from the technologies that they have developed, and A*STAR offers advice and help in testing the robustness and viability of their ideas. At the outset, we ask our scholars to think and plan creatively, and the only mandate we impose on them is to bring benefit to Singapore.

NURTURING SCIENTIFIC TALENTS THE A*STAR WAY

Gain a top-notch education locally or overseas through our wide array of scholarships, ranging from undergraduate to PhD to post-doctoral.

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Can you share what your typical day at work is like? At A*GA, our main concern is the welfare of the scholars and students who are under our care. We constantly review the support that we provide, and find opportunities to strengthen the bonds between the scholars and the organisation. A typical day could begin with a review of existing policies, followed by a discussion of problems faced by a scholar in training or a request for leave of absence. The afternoon could be spent on analysing the effectiveness of our STEM outreach programmes as well as discussing ways to strengthen our several overseas partnerships. The day usually ends with a surf on Facebook, to keep myself updated on some of the latest trends while also reading up the posts or comments by our scholars. It is always heartening to read their comments as it enables me to appreciate them as they are, while also keeping in tune with the scholars’ views. At A*STAR, we care about the future of our scientific talent, a major part of which would be our scholars. At the end of the day, I want to see a success story in every scholar, each forging his or her own way ahead.

Arm yourself with the necessary skills you need to excel as a scientist with our variety of research attachments.

Talent Times Vol. 7

Explore opportunities within the industry, join a start-up, intern at a leading technology firm or start-up your own company.

Change the future with an A*STAR scholarship Cancer is a highly complex disease with patients responding very differently to treatments. Treatment failure has been attributed to rare cancer stem cells growing within tumors and resisting conventional therapies. The team of scientists at A*STAR worked with clinicians to pinpoint the hallmarks of cancer stem cells that can be controlled and treated. Using advanced pre-clinical human tumors models, we were able to demonstrate that the therapeutic agents discovered can act specifically and potently against cancer stem cells. These findings catalyzed extensive clinical and industry collaborations to develop new clinically viable drugs that may finally put an end to cancer progression and give patients a new lease of life.v

OUR SCIENTISTS HAVE UNLOCKED SECRETS OF CANCER STEM CELLS THAT WILL MAKE THEM VULNERABLE TO NEW DRUGS

Dr. Tam Wai Leong A*STAR Scholar Principal Investigator, Genome Institute of Singapore, A*STAR and Cancer Science Institute of Singapore, National University of Singapore

Targeting cancer stem cells

Adjunct Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore

Building pre-clinical human tumor avatars

If you are challenged by the demands of the future, move ahead with an A*STAR scholarship.

Developing better drugs

Dr. Daniel Tan Clinician-Scientist Fellow, Genome Institute of Singapore, A*STAR Senior Consultant, Division of Medical Oncology, National Cancer Centre Singapore Adjunct Associate Professor, Duke-NUS Medical School

CREATING GROWTH, ENHANCING LIVES

Apply for an A*STAR scholarship at www.a-star.edu.sg

Precision oncology