Jun 22, 2011 - and 28 days respectively each, while Groups A2 and B2 were withdrawal groups for A1 and B1 which .... at
International Journal of Medicine and Medical Sciences Vol. 3(6), pp. 219-222, June 2011 Available online http://www.academicjournals.org/ijmms ISSN 2006-9723 ©2011 Academic Journals
Full Length Research Paper
Effect of monosodium glutamate on hematological parameters in Wistar rats Ashaolu J. O.1*, Ukwenya V. O.1, Okonoboh A. B.2, Ghazal O. K.2, Jimoh A. A. G.3 1
Department of Anatomy, College of Health Sciences, Bowen University, Iwo, Osun State, Nigeria. Department of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria. 3 Department of Obstetrics and Gynaecology, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria.
2
Accepted 22 June, 2011
Monosodium glutamate (MSG) is a food additive commonly consumed as a flavor enhancer. However, both animal models and human clinical reports have established its harmful effects. The rats in two groups (A1 and B1) were administered with 5.5 g/kg body weight (b.wt) and 2.75 g/kg b.wt of MSG for 14 and 28 days respectively each, while Groups A2 and B2 were withdrawal groups for A1 and B1 which were sacrificed 14 days post-administration. At the end of the study periods, blood samples were analyzed for hematological parameters. Test results showed significant effect (p
