Figure S1 D A C B E H G F S LE BM a s pira te S LE BM b iops y BT BT

0 downloads 113 Views 620KB Size Report
Figure S1. D. A. C. B. Meg. E. H. G. F. LE. S. LE. BM a s pira te. S. LE. BM b iops y. LE cells. PC. Dyspoietic erythroi
Figure S1

SLE BM aspirate

A

Dead cells

B Dyspoietic erythroid cells

Meg

D

C ↑ plasma cells

PC

LE cells

SLE BM biopsy

E

G

BT

LE

F

H

BT

Figure S1. Abnormalities in human SLE BM aspirates. BM aspirates from SLE patients were stained with Wright-Giemsa (A-D) and BM biopsies with H&E (E-H). A, Numerous apoptotic/necrotic cells (arrowheads). B, Erythroid dyspoiesis (arrows) with inset showing megakaryocytic cells engulfing nuclear material (red arrowhead). C, Increased plasma cells (PC, arrowheads). D, LE cells (red arrowheads and inset) and hemophagocytosis by a macrophage (green arrow). E, BM showing low cellularity. F, BM stromal damage with disorganization/degeneration. G, interstitial lymphoid aggregate. H, moderately increased reticulin fibers due to reactive stromal fibroblast activation. BT, bone trabeculae.