Hepatitis B - World Health Organization

... of Communicable Diseases Surveillance and. Response. This document has been downloaded from the WHO/CSR Web site. See http://www.who.int/emc for ...
706KB Sizes 3 Downloads 221 Views
WHO/CDS/CSR/LYO/2002.2:Hepatitis B

Hepatitis B

World Health Organization Department of Communicable Diseases Surveillance and Response This document has been downloaded from the WHO/CSR Web site. See http://www.who.int/emc for more information.

© World Health Organization This document is not a formal publication of the World Health Organization (WHO), and all rights are reserved by the Organization. The document may, however, be freely reviewed, abstracted, reproduced and translated, in part or in whole, but not for sale nor for use in conjunction with commercial purposes. The views expressed in documents by named authors are solely the responsibility of those authors. The mention of specific companies or specific manufacturers' products does no imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. The designations employed and the presentation of the information in this document do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.

Hepatitis B

Table of contents ACKNOWLEDGEMENTS....................................................................................................................... 5 HEPATITIS B - AN INTRODUCTION ..................................................................................................... 6 What causes the disease? ................................................................................................................ 6 How is HBV spread? ......................................................................................................................... 6 Who is susceptible to infection?...................................................................................................... 7 Where is HBV a problem, globally? ................................................................................................. 7 When is hepatitis B contagious? ..................................................................................................... 8 Why is there no treatment for the acute disease?.......................................................................... 8 THE HEPATITIS B VIRUS HBV ........................................................................................................... 10 The hepatitis B virus life cycle ....................................................................................................... 12 Scheme of genome replication....................................................................................................... 13 Morphology and physicochemical properties .............................................................................. 13 Schematic representation of viral particles found in serum of HBV-infected people ..................... 14 Genome and proteins...................................................................................................................... 15 HBV coding organization................................................................................................................ 17 Hepatitis B virus DNA and hepatocellular carcinoma .................................................................... 17 HBV mutants .................................................................................................................................. 18 Nomenclature of hepatitis B ........................................................................................................... 19 Antigenicity ...................................................................................................................................... 19 Stability............................................................................................................................................. 20 THE DISEASE .........