antigens of Salmonella adelaide may be induced in vitro by the exposure of mouse spleen cells for 6 hr to an immunogenic
Immunological tolerance, // J. Wiley & Sons, 1998 // 1998 // 9780471978435 // Gregory Bock, Jamie Goode // 240 pages Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein, the mammalian immune system discriminates between modes of cell death; necrosis often results in inflammation and adaptive immunity, whereas apoptosis tends to be anti-inflammatory and promote immune tolerance. We have examined apoptosis for the features. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques, two methods were used to demonstrate the presence of tumor-specific antigens in adenocarcinomata of the human colon:(a) rabbits were immunized with extracts of pooled colonic carcinomata, and the antitumor antisera thus produced were absorbed with a pooled. Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways, cancer vaccines targeting'self'antigens that are expressed at consistently high levels by tumor cells are potentially useful in immunotherapy, but immunological tolerance may block their function. Here, we describe a novel, naked DNA vaccine encoding an alphavirus. Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression, treatment of patients with allergic asthma using low doses of peptides containing T cell epitopes from Fel d 1, the major cat allergen, reduces allergic sensitization and improves surrogate markers of disease. Here, we demonstrate a key immunological mechanism. Immunological tolerance: the key feature in human filariasis, filariasis is a widespread tropical disease caused by a group of nematode parasites that can survive for many years in immunocompetent hosts. The paradox of filariasis has always been the inverse association between parasite density, in terms of circulating microfilariae. Tim-3 inhibits T helper type 1-mediated auto-and alloimmune responses and promotes immunological tolerance, abstract Although T helper (TH) cell-mediated immunity is required to effectively eliminate pathogens, unrestrained TH activity also contributes to tissue injury in many inflammatory and autoimmune diseases. We report here that the TH type 1 (TH 1)-specific Tim-3 (T cell. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self, abstract Naturally arising CD25+ CD4+ regulatory T cells actively maintain immunological self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. A reduction in their number or function can also elicit tumor immunity, whereas their. Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells, in this study we examined the immunological parameters underlying the natural immunity to inhaled nonpathogenic proteins. We addressed this question by examining the effect of intranasal exposure to OVA in both wild-type mice and mice reconstituted with OVA-TCR. Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance, oral administration of antigens, including allergens and autoantigens, may be an efficient way to prevent diseases associated with untoward immune responses to self-and non-self-antigens. However, this approach has met with limitations because it usually requires. Induction of immunological tolerance by porcine liver allografts, liver allografting experiments with pigs show that animals given no immunosuppression will survive for prolonged periods with orthotopic liver transplants. Similar animals can reject skin, kidneys and hearts rapidly. Orthotopic and accessory heterotopic liver allografts protect. Immunological tolerance, immunologieal tolerance may be described as a state of indifference or nonreactivity towards a substance that would normally be expected to excite an immunologieal response. The term first came to be used in the context of tissue transplantation immunity? that. Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity, iT has been shown in mice that specific immunological unresponsiveness to contact sensitisation with picryl chloride induced by pretreatment with picryl sulphonic acid is a positive phenomenon rather than an absence of specific immunocompetent cells 1. In this. A mechanism for the induction of immunological tolerance by antigen feeding: antigen-antibody complexes, we have previously reported on the induction, in mice, of a systemic (splenic) immune response with IgA as the dominant antibody, as a result of a short (4 day) intragastric immunization course with foreign erythrocytes. This response was followed by a prolonged. Infectious immunological tolerance, previous studies have shown that thymectomized lethally irradiated bone marrow grafted mice, reconstituted with thymocytes and pretreated with a large dose of sheep red blood cells (SRBC), are unable to respond to a subsequent immunizing injection of SRBC even. Intranasally induced immunological tolerance is determined by characteristics of the draining lymph nodes: studies with OVA and human cartilage gp-39, mucosal tolerance is a naturally occurring immunological phenomenon that prevents harmful inflammatory responses to ingested or inhaled environmental, predominantly nondangerous, Ags. The nasal mucosa is an extremely efficient compartment. CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance, we examined the relationship between cell death and tolerance induction following antigen injection into the anterior chamber of the eye. Our data show that when inflammatory cells undergo apoptosis following infection with HSV-1, tolerance to the virus was observed. Drug-induced immunological tolerance, pREVIOUS work in this laboratory demonstrated that administration of a purine analogue, 6-mercaptopurine, suppressed the antibody response to a soluble antigen (human serum albumin) in rabbits 1. It was shown that the antimetabolite could block completely. The PD-1-PD-L pathway in immunological tolerance, since the first observation of spontaneous autoimmune diseases in programmed cell death 1 (PD-1) knockout mice, PD-1 has been postulated to have essential roles in the regulation of autoimmunity but the precise mechanism was largely unknown. Recent studies clearly. Antibody-mediated suppression of the immune response in vitro: II. A new approach to the phenomenon of immunological tolerance, immunological tolerance to H antigens of Salmonella adelaide may be induced in vitro by the exposure of mouse spleen cells for 6 hr to an immunogenic dose of polymerized flagellin in the presence of low concentrations of specific antibody. Such antibody-mediated. Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance, emerging evidence suggests critical roles for APCs in suppressing immune responses. Here, we show that zymosan, a stimulus for TLR2 and dectin-1, regulates cytokine secretion in DCs and macrophages to induce immunological tolerance. First, zymosan induces. by DAW Wolvers, CJJ Coenen
