M ATTHEW D. M ANSH 5150 Diamond Heights Blvd, Apt B306 • San Francisco, CA 94131 •
[email protected]
EDUCATION Stanford University, Stanford, California
MD
2015
SCHOLARLY CONCENTRATION: Molecular Basis of Medicine & Cancer Biology RESEARCH WORK: “ZFN-mediated gene therapy in iPSC models of sickle disease” RELEVANT COURSEWORK: Translational Immunology, Clinical Basis of Cancer Biology, Bioengineering,
Pharmaceutical Bioinnovation, Entrepreneurship: Formation of New Ventures
Haverford College, Haverford, Pennsylvania
Bachelor of Science
2008
MAJOR: Molecular Biology MINOR: Chemistry THESIS: “A novel role for the classic morphogen Sonic Hedgehog in Retinal Ganglion Cell Axon Guidance” RELEVANT COURSEWORK: Cell Signaling, Advanced Genetics, Biochemistry, Vaccine Development,
Immunology, Biopsychology, Physical Chemistry, Molecular Neurobiology
King’s College London, London, England
Junior Year Abroad (JYA)
2007
PROGRAM: Medicine, Biochemistry, and Pharmacology DISSERTATION: “Maternal mortality and healthcare economics under neoliberal reforms in Mexico” RELEVANT COURSEWORK: Practice of Medicine, Regenerative Medicine, Cardiovascular Pharmacology
R E RESEARCH EXPERIENCE L E V Medical Scholar, UNIVERSITY OF CALIFORNIA, SAN FRANCISCO , San Francisco, CA 2013- Present A Clinical research investigator in the lab of Dr. Sarah Arron at the University of California, San Francisco. Work comprises studying a personalized genomics approach to asses both clinical andNgenetic risk factors for developing squamous cell T carcinoma and invasive aspergillosis in lung transplant recipients taking prophylactic voriconazole. C O Investigator, LGBT MEDICAL EDUCATION RESEARCH GROUP (MERG), Stanford, CA 2011- Present U Research investigator on the LGBT MERG project established to study R LGBT education in the United States and Canadian medical schools. Work comprises two projects aimed at developing San interactive database for LGBT medical curricular materials and analysis of a study concerning the perspectives of LGBT E students during undergraduate medical education. W O Medical Scholar, STANFORD SCHOOL OF MEDICINE, Stanford, CA 2011- 2012 Medical Scholars research project in the lab of Dr. Matthew Porteus R in the Department of Pediatric Hematology at Lucille K focused on the development of Zinc Finger Nuclease Packard Children’s Hospital. Independent basic science research project
: in an effort to develop novel cell replacement therapy. (ZFN) mediated gene therapy in ES cell models of Sickle Cell Disease One of 40 national recipients of an American Society of HematologyP(ASH) Research Trainee Award for project support. r a Research Assistant, CHILDREN’S HOSPITAL OF PHILADELPHIA , Philadelphia, PA 2008-2010 c Independent research in the lab of Paul Gadue studying the role of TGF-Beta signaling in the formation of endoderm using t mouse and human embryonic stem cells. Served as active member ofi the newly formed Center for Cellular and Molecular Therapeutics. Extensive laboratory work supplemented by literature based research, collaboration with a diverse set of c researchers and physician-scientists, and attendance at local and national conferences. e o Howard Hughes Interdisciplinary Scholar, HAVERFORD COLLEGE, Haverford, PA 2006- 2008 f Received two undergraduate grants from HHMI to conduct independent M research in the lab of Andrea Morris on the mechanisms by which protein guidance cues regulate neural development in the visual system of the African frog Xenopus Laevis. Extensive e laboratory work supplemented by literature based research, collaboration with colleagues, and presentations at local conferences. d i c i n e , T
Research Assistant, KING’S COLLEGE LONDON SCHOOL OF MEDICINE, London, UK
2007
Research investigation working in the lab of Dr. Michael Curtis on an independent project to assess the target selectivity and toxicity of novel potassium channel drugs utilizing the Langendorrff preparation in rat models of reperfusion induced arrhythmias.
PUBLICATIONS Mansh, M., Amann, L.C., Cheng, X., Ying, L., Disimone, A., and Gadue, Paul. Lhx1 is a TGF-beta induced regulator of endoderm formation from embryonic stem cells. (manuscript in preparation). Lesbian, Gay, Bisexual, and Transgender Medical Education Research Group (LGBT MERG), (2013). Medical Student Comfort and Preparedness in Caring for LGBT Patients. Teaching and Learning in Medicine: An International Journal, 25: 112. Mansh, M. (2011). Ipilimumab and Cancer Immunotherapy: A New Hope for Advanced Melanoma. Yale Journal of Biology and Medicine. 84(4): 381–389. Gordon, L., Mansh, M., Kinsman, H. and Morris, A. R. (2010). Xenopus sonic hedgehog guides retinal axons along the optic tract. Developmental Dynamics, 239: 2921–2932. Kinsman, H., Mansh, M., Carlson, L., and Morris, A. (2008). Xenopus sonic hedgehog is involved in retinal axon guidance. Developmental Biology, 39(2): 540.
PRESENTATIONS Nuclease Enhanced Homologous Recombination in Human ES Cells for a Gene Therapy Approach to Treating Sickle Cell Disease Internal Medicine 2013: San Francisco, CA
April 2013
Nuclease-Mediated Homologous Recombination in Human Embryonic Stem Cells for a Gene Therapy Approach to Treating Sickle Cell Disease 29th Annual Medical Student Research Symposium: Stanford, CA
May 2012
National Survey Results: Medical Student Comfort and Preparedness in Caring For LGBT Patients Society for Teachers of Family Medicine: Medical Education Conference: Long Beach, CA
February 2012
Lesbian, Gay, Bisexual and Transgender Medical Student Student Experiences: “Out” in Medical School and Perspectives on Curricular Content. AAMC Research in Medical Education (RIME) Annual Conference: Denver, CO
November 2011
Transgender Content in Medical Curricula. 28th Annual Medical Student Research Symposium: Stanford, CA
May 2011
Identification of novel markers of early endoderm and their regulatory effects. UPenn's Institute for Diabetes Spring Symposium: Philadelphia, PA
March 2010
A novel role for Activin/Nodal and BMP Signaling in Endoderm Formation UPenn's Institute of Regenerative Medicine Annual Retreat: Philadelphia, PA
February 2010
“Lhx1, a novel target of Activin A/Nodal signaling during endoderm formation.” Keystone Symposia: Stem Cell Differentiation and Dedifferentation: Keystone, Colorado
February 2010
“A novel role for Activin/Nodal and BMP Signaling in Endoderm Formation.” UPenn’s Colloquim on "Translating Islet Biology into Clinical Therapy”: Philadelphia, PA
October 2009
“A novel role for Activin/Nodal and BMP Signaling in Endoderm Formation.” International Society for Stem Cell Research (ISSCR) Annual Retreat: Barcelona, Spain
July 2009
“Xenopus Sonic Hedgehog Guides Retinal Axons Along the Optic Tract” Society for Developmental Biology Annual Meeting: Orlando, Florida
June 2008
“Xenopus Sonic Hedgehog controls axon guidance along the optic tract” Undergraduate Science Research Symposium: Haverford, PA
October 2007
“Defining a role for hedgehog genes in axon guidance.” Undergraduate Science Research Symposium: Dickinson, PA
October 2006
ACTIVITIES Treasurer, LGBT MEDS, Stanford, CA
2011- Present
Led a medical student orientation organization centered out both creating a vibrant support community for LGBT medical students and health professionals and for representing and advocating for LGBT curricular changes at Stanford Medical School. Organized social gatherings, campus wide mixers, and off-campus LGBT retreats, created a Stanford “Out List” to facilitate mentorship opportunities, and helped run an elective course for medical students focused on “Queer Health and Medicine”. Currently in the process of drafting an AMA resolution to include sexuality and gender identity data collection in AMA sponsored surveys.
Arbor Free Clinic Steering Committee, CARDINAL FREE CLINICS, Stanford, CA
2011-2012
Served as board member on the Arbor Free Clinic Steering Committee, a Stanford run free clinic serving uninsured patients in Menlo Park and East Palo Alto. Helped develop broad organizational goals, fostered new clinical initiatives, organized for funding, and oversaw recruitment of medical students and other volunteers.
Teaching Assistant, STANFORD SCHOOL OF MEDICINE Stanford, CA
2011
Served as a teaching assistant for a first-year medical school course, Cells to Tissues, highlighting basic cell biology, histology, cell signaling, development, etc. Led twice weekly histology lab sections, weekly literature review discussion sessions on basic science and translational primary research, led scientifie method review sections, assisted with the production of graded quiz material, privately tutored students and held weekly office hours.
SWEAT Leader, STANFORD UNIVERSITY SCHOOL OF MEDICINE, Stanford, CA
2011
Team leader and mentor on planned medical school orientation trip consisting of a 4-day hiking and camping excursion in the Sierra Nevada Mountains. Extensive training in leadership and mentorship through a course-based lecture series. Wilderness First Aid trained and certified.
Laboratory Instructor, HAVERFORD BIOLOGY DEPARTMENT, Haverford, PA
2008
Served as laboratory instructor and teaching assistant for an upper level molecular biology course on neural stem cell biology and differentiation offered to juniors and seniors in the biology department. Assisted students with fluorescent microscopy and image analysis of cultured neurons and oligodendrocytes twice weekly.
Social Medicine Seminar Leader, CENTER FOR PEACE AND GLOBAL CITIZENSHIP
2008
Led a discussion based, student-run seminar course focused on the political, economic, and social impacts of medicine, from the realities of infant mortality in Brazil to the ethics of stem cell research on a national and global scale. Responsibilities included designing and planning a syllabus for the course, organizing trips to regional health conferences, and advising a group of twelve underclassmen on careers in medicine.
Marathon Runner
2006-Present
Completed the 2006 Philadelphia Marathon (4:15), the 2007 ING New York City Marathon (3:54), and the 2009 Philadelphia Marathon (4:10).
Teaching Assistant Coordinator, HAVERFORD BIOLOGY DEPARTMENT, Haverford, PA
2006-2008
Led and organized twice-weekly lecture question and answer sessions for undergraduates taking introductory and advanced biology courses. Responsible for coordinating a team of eight department tutors and arranging private tutoring when necessary.
Admissions Associate, HAVERFORD ADMISSIONS DEPARTMENT, Haverford, PA
2005- 2008
Led self-designed tours of Haverford’s campus to prospective students, hosted guests in the waiting room before interviews, and collaborated with admissions officers on molding future classes. Served as a summer intern in 2005, working full-time in the office and serving as an assistant to admissions counselors.
Member, AIDS SERVICE NETWORK
2005- 2007
Volunteered with local AIDS service organizations in Philadelphia, including the AIDS Walk and Gay Bingo. Interned for a week at the Gay Men’s Health Crisis in Manhattan and interacted with HIV+ patients. Served on various committees responsible for bringing the AIDS quilt to Haverford College.
Residential Advisor and Student Resource Person (SRP), HAVERFORD COLLEGE
2005 - 2007
Served as Customs Person (CP) for first year students, living as a residential advisor in a freshman dorm. Led and facilitated discussions on alcohol, religion, sexuality, gender, and individual health, while also serving as an academic advisor for a diverse, multicultural group of new students. Additionally served as a student advisor to a group of transfer and international exchange students from around the globe.
Student Council Representative, HAVERFORD COLLEGE STUDENTS COUNCIL
2004 - 2005
Discussed and formulated campus life and policy issues as a class representative at weekly council meetings. Served on budgeting committee responsible for allocating over $300,000 of student activities funds to campus organizations and events.
CLINICAL EXPERIENCE Coordinator, ARBOR NEUROLOGY SPECIALTY CLINIC, Menlo Park, CA
2011-2012
Lead coordinator of a monthly neurology specialty clinic at Arbor Free Clinic. Established referral system for neurology patients from local community clinics, scheduled patients, recruited attendings to staff clinic, and assisted in conducting and teaching pre-clinical students the neurological physical exam.
Volunteer, ARBOR FREE CLINIC, Menlo Park, CA
2010-2012
Volunteered monthly at Arbor Free Clinic, a student run community clinic located at the VA Menlo Park Hospital. Interviewed patients, performed physical examinations, completed patient paper work, referrals, and prescriptions, and assisted in specialty clinics including dermatology, women’s health, and cardiology.
Volunteer, WASHINGTON WEST PROJECT, Philadelphia, PA
2009-2010
Volunteered weekly (4 hours/week) as a staff assistant and patient coordinator at the Washington West Project, a free HIV testing center in Center City Philadelphia that caters to the members of the LGBQT community.
Volunteer, PENNSYLVANIA HOSPITAL, Philadelphia, PA
2008
Spent ten weeks (4 hours/week) as a volunteer in Emergency Medicine at Pennsylvania Hospital. Worked with physicians, nurses, and other health professionals to provide a warm atmosphere for patients. Observed physicians and assisted staff with care of patients.
Extern, JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE, Baltimore, MD
2008
Shadowed Jeffrey Rumbaugh, MD, PhD, residents, and medical students over a two week period in the Department of Neurology. Clinical experience included stroke, general neurology, and a specialized multiple sclerosis clinic. Lab experiences included studying rat models of HIV dementia.
Extern, NATIONAL HEALTH SERVICE (NHS), London, UK
2007
Shadowed physicians, nurses, and health professionals and worked in number of clinical settings over five weeks throughout diverse sections of London. Clinical experiences included general practice, palliative care, district nursing, emergency medicine, cardio-thoracic surgery, sexual health clinics, walk-in centers, and homeless clinics.
Volunteer, LYDIA CLINIC OF ST. THOMAS HOSPITAL, London, UK
2007
Worked and shadowed physicians in the genito-urinary/sexual health clinic of St. Thomas Hospital for 3-4 hours/week over a 9 week period. Escorted patients to examination rooms, observed consultations, and assisted the waiting room staff.
Volunteer, GAY MEN’S HEALTH CRISIS, New York, NY
2006
Volunteered for one week in the food service program of the GMHC, preparing and serving meals to disadvantaged HIV positive patients. Interned briefly in the legal department, worked on advertising campaigns for the NYC AIDS Walk and took part in holistic healing sessions with patients.
Extern, BUCKS COUNTY DEPARTMENT OF HEALTH, Warrington, PA
2004
Externship with the head of epidemiology of Bucks County, Pennsylvania over a one week period. Shadowed physicians and social workers in a prenatal care clinic for low-income mothers and spent two days working with nurses and inmates at the health center of a local corrections facilities.
HONORS AND AWARDS Markowski-Leach Scholarship Beckman Medical Scholar, Stanford University American Society of Hematology (ASH) Research Trainee Award Ariel L. Loewy Prize for Senior Research High Honors, Haverford College Department of Biology Howards Hughes Medical Institute (HHMI) Interdisciplinary Scholar
2012 & 2013 2011 2011 2008 2008 2006 & 2007
