Service, Ireland. Relative risk was deter- mined as the observed ..... c n d 5 u d d t , D . o t r , C r r n r F . i ' p
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Br J Psychiatry1998Oct;173:325-9
Mortality in schizophrenia.Antipsychoticpolypharmacyand absenceof adjunctiveanticholinergicsover the courseof a 10year prospectivestudy. Waddington JL, Youssef HA, Kinsella A Departmentof Clinical Pharmacology,Royal College of Surgeonsin Ireland, Dublin.
[email protected] BACKGROUND: Although increasedmortality is one of the most consistentand accepted epidemiologicalfindings in schizophrenia,a high rate of suicideappearsunableto account fully for this burdenwhich remainspoorly understood.METHOD: A cohort of 88 in-patientswas followed prospectivelyover a l0-year period and predictorsof survival sought among demographic,clinical and treatmentvariables.RESULTS: Over the decade,39 of the 88 patients(44%) died, with no instances of suicide.Reducedsurvival was predictedby increasingage,male gender,edentulousness and time sincepre-terminalwithdrawal of antipsychotics;additionally,two indicesof polypharmacypredicted reducedsurvival: maximum numberof antipsychoticsgiven concurrently(relative risk2.46,95% Cl T.l0-5.47;P : 0.03) and absenceof co-treatmentwith an anticholinergic(relativerisk 3.33, 95% CI 0.99-11.1l; P : 0.05). CONCLUSIONS:Receivingmore than one antipsychoticconcurrentlywas associatedwith reducedsurvival, in the face of little or no systematicevidenceto justify the widespreaduse of antipsychoticpolypharmacy.Conversely,over-cautiousattitudesto the use of adjunctiveanticholinergicsmay require re-evaluation. PMID: 9926037.W. 99124860
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i'lortality in schizophrenia .\ntrpsychotic and absenceof adjunctive oolypharmacy
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t h c c i r c u n r s t a n c c so i e a c h d c : r t h r v a s t h e r c fore available. 1'he objectivc oi thc present study was to idcntifi' predictors oi reduccd
andANTHONY KINSELLA l o H N L . W A D D I N G T O N ,H A N A F Y A . Y O U S S E F
survival over a 10-ycar pcriod in circumstances that allowed isolation of nons u i c i d e - r e l a t e do r o t h e r n o n - n a t u r a l c a u s c s .
METHOD
Background Althoughincreased '' ,.r:ialrtyisone ofthe most consistent
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as t l o g i c a l i i n c l i n g s ( . af b l e n s k r ' , 1 9 9 . 5 ); irr the
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Method
A c o h o r to f 8 8 r n - p a t i e n t s
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