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The contribution of metabolomics research to the environmental risk assessment of genetically modified plants A literature review

Ruud A. de Maagd & Robert D. Hall

Commissioned by The Netherlands Commission on Genetic Modification (COGEM) and the GMO office of the National Institute for Public Health and the Environment (RIVM)

Clusters Plant Development Systems and Metabolic Regulation, BU Bioscience, Plant Research International, Wageningen University and Research Centre, Wageningen, The Netherlands

Plant Research International, part of Wageningen UR Business Unit Bioscience September 2013

Report 528

© 2013 Wageningen, Foundation Stichting Dienst Landbouwkundig Onderzoek (DLO) research institute Plant Research International. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior written permission of the DLO, Plant Research International, Business Unit Bioscience

Plant Research International, part of Wageningen UR Business Unit Bioscience Address Tel. Fax E-mail Internet

: : : : : :

Droevendaalsesteeg 1, Wageningen, The Netherlands P.O. Box 619, 6700 AP Wageningen, The Netherlands +31 317 48 60 01 +31 317 41 80 94 [email protected] www.pri.wur.nl

PREFACE Assigned by the Netherlands Commission on Genetic Modification (COGEM) and the National Institute for Public Health and the Environment (RIVM), an exploratory desk study was performed concerning “The contribution of metabolomics research to the environmental risk assessment of genetically modified plants.” This report describes the state of the art in metabolomics research and the expected developments in this research field in the future. Metabolomics aims to give a wide overview of all metabolites present in a specific sample of a plant at a specific time. In the interaction with the environment changes in metabolite composition play an important role. Such composition might be influenced by genetic modification, both intentionally and unintentionally. This raised the question whether metabolomics could be used in the risk analysis of transgenic plants and in this way improve the existing Environmental Risk Assessment (ERA) procedures. Such studies on metabolomics are not yet required for the assessment. The main conclusion of the report is that metabolomics is a fast developing discipline and might in the future contribute to ERA of transgenic crops; however, the potential contribution to ERA is limited for the time being. This is mainly due to the fact that there is limited knowledge of the role of any particular metabolite in the interaction of a particular plant with a particular component of the environment. The study was performed by Dr. Ruud de Maagd en Dr. Robert Hall of Plant Research International, part of Wageningen UR, and was supervised by a committee consisting of experts in the field of metabolomics and GM regulations.

Chairman Advisory Committee Prof. dr. J.J.M. Dons

ADVISORY COMMITTEE Prof. Dr. J.J.M. Dons, BioSeeds B.V., member of COGEM Prof. Dr. R. Verpoorte, Leiden University Dr. J.M. Kooter, Vrije Universiteit Amsterdam, member of COGEM Prof. Dr. Ir. Nicole van Dam, department of Ecogenomics, Radboud University Nijmegen Dr. D.C.M. Glandorf, GMO office, National Institute of Public Health and the Environment B. Erkamp MSc, COGEM Secretariat

Table of contents Page

Samenvatting

2

Summary

5

1

7

Introduction 1.1 1.2

1.3 2

State of the art in metabolomics and expected future developments

14

2.1

14 14 14 14 15 16 16 16 17 17 17 17 18

2.2

2.3

3

Current state of the art 2.1.1 Metabolomics is the science of measuring small mo