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Apr 29, 2012 - analysis and construction of a clinical lung metastasectomy ... for survival [9-13]; however, conflicting
original articles

Annals Of Oncology

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Annals of Oncology 23: 2649–2655, 2012 doi:10.1093/annonc/mds100 Published online 29 April 2012

Colorectal cancer pulmonary oligometastases: pooled analysis and construction of a clinical lung metastasectomy prognostic model S. Salah1*, K. Watanabe2,3, S. Welter4, J. S. Park5, J. W. Park6, J. Zabaleta7, F. Ardissone8, J. Kim5, M. Riquet9, K. Nojiri10, M. Gisabella8, S. Y. Kim6, K. Tanaka10 & B. Al-Haj Ali1 1

Medical Oncology Department, King Hussein Cancer Center, Amman, Jordan; 2Department of Surgery, Tohoku University, Sendai; 3Department of Surgical Oncology, National Cancer Center Hospital East, Chiba, Japan; 4Department of Thoracic Surgery and Thoracic Endoscopy, Ruhrlandklinik, Essen, Germany; 5Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 6Center for Colorectal Cancer, National Cancer Center. Gyeonggi-do, Korea; 7Thoracic Surgery Service, Hospital Donostia, San Sebastian, Spain; 8Department of Clinical and Biological Sciences, Thoracic Surgery Unit, University of Turin, San Luigi Hospital, Orbassano (Torino) Italy; 9Department of Thoracic Surgery, Georges Pompidou European Hospital, Paris-Descartes University, Paris, France; 10Department of Gastroenterological Surgery, Yokohama City University, Yokohama City, Japan

Received 3 December 2011; revised 14 February 2012; accepted 15 February 2012

Background: Although resecting colorectal cancer (CRC) pulmonary metastasis is associated with long-term survival, identification of prognostic groups is needed for future randomized trials, and construction of a lung metastasectomy prognostic model (LMPM) is warranted. Patients and methods: We searched the PubMed database for retrospective studies evaluating prognostic factors following resecting CRC lung metastasis. Individual patient data were analyzed. Independent prognostic factors were used to construct an LMPM. Results: Between 1983 and 2008, 1112 metastasectomies were carried out on 927 patients included in eight studies. Five-year survival rate was 54.3% following the first lung resection. Multivariate analysis identified three independently poor prognostic factors: pre-thoracotomy carcinoembryonic antigen ≥5 ng/ml, disease-free interval