Jul 31, 2012 - and more thick-cap fibroatheroma, but fewer non-culprit lesion major adverse ...... Cox Adjusted HR: 0.38
DOI: 10.1161/CIRCULATIONAHA.111.055004
Prevalence, Distribution, Predictors, and Outcomes of Patients with Calcified Nodules in Native Coronary Arteries: A Three-Vessel Intravascular Ultrasound Analysis from PROSPECT Running title: Xu et al.; Calcified coronary nodules in PROSPECT Downloaded from http://circ.ahajournals.org/ by guest on October 4, 2017
Yingjia Xu, MD1*; Gary S. Mintz, MD1; Anthony Tam, BA1; John A. McPherson, MD2; Andres Iniguez, MD3; Jean Fajadet, MD4; Martin Fahy, MD1; Giora Weisz, MD1; Bernard Bern rnar ardd De Bruyne, ar Bru ruyn yne, yn MD, PhD5; Patrick W. Serruys, MD, PhD6; Gregg W. Stone, MD1; Akiko Maehara, MD1 1
2
Columb Columbia C o mb bia Univ Uni nivv Medical Medi Me dica cal Center Ce er & Cardiovascular Car a di d ov ovaascuular Research Res esea e rchh Foundation, F un Fo unda dattion,, New New York, Yoork rk,, NY;; 3 Vanderbilt V Vanderbi a ilt U Univ niv Me niv Medi Medical diica call Ce Cent Center, nter nt e , Na er N Nashville, ash shviill l e, T TN; N; Ho Hospital osp spit ital it al M Meixoeiro, e xo ei xoei eiiro, Vi Vigo, igo go,, Sp Spai Spain; ain; ai n; 4Cl Clinique Clin iniq in ique iq u Pasteur, Pasteur, Tou Toulouse, ulo ousee, F France; rannce; e; 5Ca Cardiovascular Card rdiiovascuula ula r C Center ennterr Aa Aal Aalst, lstt, OLV LV Ho Hospital, osppitaal,, Aals Aalst, st, Belgium; Beelg gium m; 6 Thoraxcenter, T horax orax xceent nterr, Er Eras Erasmus asmu m s Medi mu M Medical edi dicaal C Center, enter nterr, Ro Rot Rotterdam, tteerda erdaam, tthe he N Netherlands ethherl et herl r an andds ds Ying Yi ngji ng jiaa Xu is ji is a permanent perm pe rman rm anen an entt employee en empl em ploy pl oyee oy ee of of Shanghai Shan Sh angh an ghai gh ai Chest Che hest st Hospital, Hos ospi pita pi tall, Shanghai ta Sha hang ngha ng haii Ji ha Jiao ao T ongg on * Yingjia Tong University, U Un iveersi iv ersity ity,, Shanghai, Shan Sh angh ghai gh aii, China Ch hin inaa
Address for Correspondence: Akiko Maehara, MD Cardiovascular Research Foundation 111 East 59th Street, 12th floor New York, NY, 10022 Tel: 646-434-4569 Fax: 646-434-4464 E-mail:
[email protected] Journal Subject Codes: [3] Acute coronary syndromes; [29] Coronary imaging: angiography/ultrasound/Doppler/CC
1
DOI: 10.1161/CIRCULATIONAHA.111.055004
Abstract:
Background - Pathologic studies suggest that calcified coronary nodules are a rare cause of thrombotic events. The frequency, distribution, predictors, and outcomes of calcified nodules have never been described. Methods and Results - Following successful stenting in 697 patients (167 female, median age=58.1 years) with acute coronary syndromes (ACS), three-vessel grayscale and virtual histology (VH) intravascular ultrasound (IVUS) was performed in the proximal-mid segments of all three coronary arteries as part of a prospective, multicenter study. Based on recent histologic Downloaded from http://circ.ahajournals.org/ by guest on October 4, 2017
validation, an independent core lab identified calcified nodules as distinct calcification with an irregular, protruding and convex luminal surface. Patients were followed for (median) three years. Overall, 314 calcified nodules were detected in 250 of 1573 analyzable arteries (1 1855 ooff 62 6233 (185 patients). Thus, the prevalence of calcified nodules was 17% per artery and 30% % pe perr pa pati tien ti ent. en t T t. wo patient. Two or more calcified nodules were detected in 48 coronary arteries (3%) in 76 patients (12%). The ocaatiion ooff th he ca alc lcif i ied nodules were
