Oct 26, 2015 - The Coronary Artery Risk Development in Young Adults (CARDIA) Study .... on electron beam CT scanners (Ch
DOI: 10.1161/CIRCULATIONAHA.114.012562
The Association of Fruit and Vegetable Consumption During Early Adulthood With the Prevalence of Coronary Artery Calcium After 20 Years of Follow-Up: The CARDIA Study Running title: Miedema et al.; Fruits, Vegetables and Coronary Calcium Downloaded from http://circ.ahajournals.org/ by guest on October 2, 2017
Michael D. Miedema, MD, MPH1,2; Andrew Petrone, MPH2, James M. Shikany, DrPH3; Philip Greenland, MD4; Cora E. Lewis, MD3; Mark J. Pletcher, MD, MPH5; J. Michael Gaziano, Gaz aziaano no,, MD2; Luc Djousse, MD, MPH, ScD2 1 2
Minneapolis Minnea Mi apo polis Heart Heart Institute and Minneapolis Heart He He Institute Foundation, Fou o ndat attion, io Minneapolis, MN;
Brigham B righam andd Women’s Wome men’ n’ss Hospital, n’ Hosp Ho spittal, Division sp Diiviisionn of of Aging, Agiing, g, and and d Boston Bosttonn Veterans Vete Ve t ranss A Affairs fffai airs rss H Healthcare e lt ea lthc hcar hc aree ar
Sys Sy System, st stem, Harv Harvard rvard Medi rv Medical dical S School, chhool, Bo B Boston stoon M st MA; A; 3Di Division ivisi sioon ooff Pre si Preventive eveentivee M Medicine, ediici c ne,, U University niv versity y ooff Al Alabama aba ab bama att B Birmingham, irmingh i ham, B Birmingham, ir irmingha ham, m A AL; L; 4 D Depts epts off P Preventive reventtive Me M Medicine dicine aand di ndd Med Medicine, diciine, Northwestern University Feinberg School of Medicine, Medicine Chicago, Chicago IL; 5Dept of Epidemiology andd Biostatistics, University of California – San Francisco, San Francisco, CA Address for Correspondence: Michael Miedema MD Minneapolis Heart Institute 920 East 28th Street, Suite 100 Minneapolis, MN 55407 Tel: 612-863-3900 Fax: 612-863-4073 E-mail:
[email protected] Journal Subject Terms: Epidemiology; Imaging; Diet and Nutrition 1
DOI: 10.1161/CIRCULATIONAHA.114.012562
Abstract
Background—The relationship between intake of fruits and vegetables (F/V) during young adulthood and coronary atherosclerosis later in life is unclear. Methods and Results—We studied participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study, a cohort of young, healthy black and white individuals at baseline (1985-1986). Intake of F/V at baseline was assessed using a semi-quantitative interview Downloaded from http://circ.ahajournals.org/ by guest on October 2, 2017
administered diet history and CAC was measured at year 20 (2005-2006) using computed tomography. We used logistic regression to adjust for relevant variables and estimate the energy-adjusted, sex-specific adjusted odds ratios (OR) and 95% confidence intervals (CI) across energy-adjust stted ed, se sexx-sp xspec sp ecif ec i ic tertiles ertiles of total servings of F/V per day. Among our sample (n=2,506), the mean (SD) age at baseline was female. base eli line ne w as 25.33 (3 ((3.5) .5) years and 62.7% were fe ema male l . After adjustment ntt ffor o demographics and or lifestyle variables, intake was associated CAC: ifesstyle variab able les, hhigher le ighe her er in inta ake ooff F/ F/V Vw ass as ssocciaatedd wi with th a llower ower ow er pprevalence revvalenc re ncee of C nc AC: OR AC (95% (0.56-0.99), lowest the 95% CI) =1.00 =1. 1.00 1. 0 (reference), (reeferrennce), 0.78 0.7 (0.59-1.02), (0. 0.599-1 1.022), and d 00.74 .744 (0 (0.5 56--0. 0 99)), ), ffrom r m thee lo ro owesst tto o th he highest tertile F/V, trend
