Tamar / Candlewick Press, 2007 / 424 pages / Mal Peet / 2007. A single ataxia telangiectasia gene with a product similar
Tamar / Candlewick Press, 2007 / 424 pages / Mal Peet / 2007 A single ataxia telangiectasia gene with a product similar to PI-3 kinase, a gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) was identified by positional cloning on chromosome 11q22-23. AT is characterized by cerebellar degeneration, immunodeficiency, chromosomal instability, cancer predisposition. Partners in cognition: Extending human intelligence with intelligent technologies, we examine how technologies, particularly computer technologies that aid in cognitive processing, can support intellectual performance and enrich individuals' minds. We distinguish between effects with and of a technology: Effects with occur when people work. The coordination of arm movements: an experimentally confirmed mathematical model, this paper presents studies of the coordination of voluntary human arm movements. A mathematical model is formulated which is shown to predict both the qualitative features and the quantitative details observed experimentally in planar, multijoint arm movements. Colloquium: Aligning molecules with strong laser pulses, we review the theoretical and experimental status of intense laser alignment a field at the interface between intense laser physics and chemical dynamics with potential applications ranging from high harmonic generation and nanoscale processing to stereodynamics. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype, gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. Requirement of the MRN complex for ATM activation by DNA damage, the ATM protein kinase is a primary activator of the cellular response to DNA doubleâ strand breaks (DSBs). In response to DSBs, ATM is activated and phosphorylates key players in various branches of the DNA damage response network. ATM deficiency causes the genetic. A systematic review of psychological factors as predictors of chronicity/disability in prospective cohorts of low back pain, objectives. To evaluate the evidence implicating psychological factors in the development of chronicity in low back pain. Summary of Background Data. The biopsychosocial model is gaining acceptance in low back pain, and has provided a basis for screening. Narrative research: Reading, analysis, and interpretation, using a new model for the classification of types of readings, this book shows how to read, analyze and interpret life story materials. The authors introduce four models: holistic-content reading; holistic-form reading; categorical-content reading; and categorical-form reading. Molecular modeling and simulation: an interdisciplinary guide: an interdisciplinary guide, very broad overview of the field intended for an interdisciplinary audience; Lively discussion of current challenges written in a colloquial style; Author is a rising star in this discipline; Suitably accessible for beginners and suitably rigorous for experts; Features extensive four. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders, advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing remain largely unknown, impeding the development of interventions that might delay or prevent age-related disorders. Biovolume calculation for pelagic and benthic microalgae, microalgal biovolume is commonly calculated to assess the relative abundance (as biomass or carbon) of co-occurring algae varying in shape and/or size. However, a standardized set of equations for biovolume calculations from microscopically measured linear dimensions. mdm2 expression is induced by wild type p53 activity, we have recently characterized a 95 kDa protein, p95, which exhibits enhanced binding to temperaturesensitive p53 (ts-p53) when cells are shifted down to 32.5 degrees C, a temperature at which ts-p53 possesses wild-type (wt)-like activities. In the present study. Protic ionic liquids: properties and applications, the field of ionic liquids (ILs) is growing at a very fast rate, as the many beneficial properties of these liquids are identified and utilized. A subset of ILs are protic ionic liquids (PILs), which are easily produced through the combination of a Brønsted acid and Brønsted base. Endovenous therapies of lower extremity varicosities: a meta-analysis, background Minimally invasive techniques such as endovenous laser therapy, radiofrequency ablation, and ultrasound-guided foam sclerotherapy are widely used in the treatment of lower extremity varicosities. These therapies have not yet been compared with. The economic burden of anxiety disorders in the 1990s, assessed the annual economic burden of anxiety disorders in the United States from a societal perspective. Using data from the National Comorbidity Study with Ss aged 15-54, the costs associated with anxiety disorders were calculated, after adjusting for demographic. A theory of causal learning in children: causal maps and Bayes nets, the authors outline a cognitive and computational account of causal learning in children. They propose that children use specialized cognitive systems that allow them to recover an accurate causal map of the world: an abstract, coherent, learned representation. Innovation, organizational capabilities, and the born-global firm, we investigate born-global firms as early adopters of internationalization-that is, companies that expand into foreign markets and exhibit international business prowess and superior performance, from or near their founding. Our explication highlights the critical role. Bacterial mercury resistance from atoms to ecosystems, bacterial resistance to inorganic and organic mercury compounds (HgR) is one of the most widely observed phenotypes in eubacteria. Loci conferring HgR in Gram-positive or Gram-negative bacteria typically have at minimum a mercuric reductase enzyme (MerA) that. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity, retinopathy of prematurity (ROP) is initiated by hyperoxia-induced obliteration of newly formed blood vessels in the retina of the premature newborn. We propose that vessel regression is a consequence of hyperoxia-induced withdrawal of a critical vascular survival. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes, in preclinical studies, a doxorubicin liposome formulation containing polyethylene-glycol (Doxil) shows a long circulation time in plasma, enhanced accumulation in murine tumors, and a superior therapeutic activity over free (unencapsulated) doxorubicin (DOX. by PE Greenberg, T Sisitsky, RC Kessler
