YL, Shi XH, Hu GQ, Jiang XY, Lab Chip, 14(10): 1673-1677. (2014). 4. A Microfluidic Origami Chip for Synthesis of Functi
Microfluidics for nano-drugs and tissue engineering Xingyu Jiang National Center for NanoScience and Technology, The University of Chinese Academy of Sciences, 100190 P. R. China E-mail:
[email protected] I will describe two important bioengineering applications of polydimethylsiloxane (PDMS) microfluidic devices. This device allows for high-pressure connection in PDMS microchips, which allows a high throughput fabrication of size-controlled synthesis of poly(lactic-co-glycolic acid) (PLGA) nanoparticles ranging from 55 to 135 nm in diameter (coated with lipid monolayers or bilayers). We show that by controllable synthesis, we can manufacture nano-drugs that can overcome resistance. Another important application of microchips is that it allows for controlled delivery and adhesion of cells on surfaces, such that complex tubular tissues can be easily constructed. .
References 1. Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery. Zhang L, Feng Q, Wang JL, Sun JS, Shi XH, Jiang XY. Angew Chem Int Ed, 54(13), 3952-3956. (2015). 2. Tunable Rigidity of (Polymeric Core)-(Lipid Shell) Nanoparticles for Regulated Cellular Uptake, Sun JS, Zhang L, Wang JD, Feng Q, Liu DB, Yin QF, Xu DY, Wei YJ, Ding BQ, Shi XH, Jiang XY, Adv Mater,, 27(8), 1402-1407. (2015). 3. A Microfluidic Tubing Method and Its Application for Controlled Synthesis of Polymeric Nanoparticles, Wang JD, Chen WW, Sun JS, Liu C, Yin QF, Zhang L, Xianyu YL, Shi XH, Hu GQ, Jiang XY, Lab Chip, 14(10): 1673-1677. (2014). 4. A Microfluidic Origami Chip for Synthesis of Functionalized Polymeric Nanoparticles, Sun JS, Xianyu YL, Li MM, Liu WW, Zhang L, Liu DB, Liu C, Hu GQ, Jiang XY, Nanoscale, 5(12): 5262-5265. (2013). Short Bio Xingyu Jiang is a professor at the National Center for NanoScience and Technology of China (NCNST), as well as at the University of Chinese Academy of Sciences (CAS). Xingyu obtained his Bachelor of Science at the University of Chicago (1999), followed by an AM (2001) and a PhD (2004) from Harvard University (Chemistry), working with Professor George Whitesides on microfluidics and cell patterning. After a short postdoctoral fellowship with Professor George Whitesides, he joined the NCNST in 2005 as a professor where he has remained since. Dr. Jiang is a “Hundred Talents Plan” Professor, and was a National Distinguished Young Scholar Awardee by the National Science Foundation of China. He was a Young Investigator of the Human Frontier Science Program. His research interest includes include surface chemistry, microfluidics, micro/nano-fabrication, cell biology, immunoassays, and nanomedicine. Dr. Jiang has published over 170 papers in peer-reviewed journals.
