University of Pittsburgh Innovation Institute

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200 Gardner Steel Conference Center. Thackeray &O'Hara Streets. Pittsburgh, PA 15260. (412) 383-7670 www.innovation.
University of Pittsburgh ID: 3880

Featured Inventor: Greg Siegle Ph.D.

Emotion Prosthetics Take Control of Your Stress In the Moment

Value Proposition For those with poorly managed stress that impairs their quality of life, Emoto is a wearable device with a mobile application interface that empowers its users to take control of their stress, before it controls them. Emoto measures physical signs of stress in real-time and alerts the user when their stress level shifts. Users can control their physical stress response with Emoto, by signaling nerves in the head and neck that are shown to relax the body or improve alertness through gentle and safe stimulation. No other product senses stress and empowers its user to control it, in real-time.

Market Opportunity

Take Control Of Your Stress with Emoto

Approximately 71 million Americans suffer from chronic stress that negatively impacts their physical and emotional health, work performance, and personal relationships. This population costs U.S. employers approximately $90 Billion each year in lost productivity, missed work hours, and health care costs. This entry market is growing, with about 19 million Americans beginning to suffer negative physical and emotional symptoms of stress each year.

Technology

Competitive Landscape

Stage of Development

Some competing consumer products track stress and others use nerve stimulation to control it, but none do both and none do it in real-time, like Emoto.

We have developed a functional prototype and have submitted a provisional patent application. In Q1 and Q2 of 2016, we will fundraise to develop our minimally viable product, begin beta testing, and will seek IRB approval for larger studies. Our goal is to license the technology by the end of 2016.

Emoto measures physical signs of stress, like heart rate variability and perspiration, over time. The device adapts to your body and discovers your baseline. Sensors detect when your stress response shifts, and the device alerts you of the change. Users can adjust their physical response to become “more calm” or “more alert”, by activating nerves in the head and neck through gentle and safe electric stimulation.

IP Landscape Provisional patent has been filed. Existing patents cover specific pieces of the proposed work, but do not reflect the breadth or integrative potential of combining them. This combination (covered in the provisional filed) is neither obvious nor trivial and the integration of these pieces represents novel content.

University of Pittsburgh

Funding Emotion Prosthetics was awarded $8,000 in funding through the University of Pittsburgh’s First Gear Program.

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FEATURED INVENTOR: Greg J. Siegle, PhD Dr. Siegle directs the Program in Cognitive Affective Neuroscience (PICAN) at the University of Pittsburgh School of Medicine, where he is an Associate Professor of Psychiatry and Psychology. His research examines neural mechanisms of emotional and cognitive information processing in mood and anxiety disorders, how this information can be used to predict response to treatment and to guide novel treatment development. He works to translate cognitive and emotional neuroscience for use in the real world. Dr. Siegle has over 115 publications, and has been continuously funded by NIH and foundation awards for over 15 years. Education Undergraduate: 1987-1991 Brown University, Providence, RI Sc.B. with honors magna cum laude (1991) Graduate: 1992-1993 Northwestern University, Evanston IL Graduate courses 1994-1996 San Diego State University M.S. (1996) 1993-1999 San Diego State University / University of California, San Diego Joint Doctoral Program Doctor of Philosophy (1999) 1998-1999 Clarke Institute of Psychiatry, Toronto, ON Clinical Internship Post Graduate: 1999-2001 Western Psychiatric Institute and Clinic, University of Pittsburgh Medical School, Pittsburgh, PA NIH Postdoctoral Fellow

Innovation Institute Carolyn J. Weber, RPh, MBA Technology Licensing Associate (412) 383-7140 [email protected]

University of Pittsburgh

Publications 1. Siegle, G. J.+, Price, R. B.+, Jones, N. P., Ghinassi, F., & Thase, M. E. (2014). You gotta work at it: Pupillary indices of task focus are prognostic for response to a neurocognitive intervention for depression. Clinical Psychological Science. + These authors contributed equally. 2(4) 455-471. 2. Siegle, G.J., Thompson, W. K., Collier, A., Berman, S. R., Feldmiller, J., Thase, M. E., & Friedman, E. S. (2012). Towards clinically useful neuroimaging in depression treatment: Prognostic utility of subgenual cingulate activity for determining depression outcome in Cognitive Therapy across studies, scanners, and patient characteristics. Archives of General Psychiatry, 69(9), 913-924. NIHMSID 524641. 3. DeRubeis, R.J., Siegle, G. J., Hollon, S., (2008). Cognitive therapy versus medications for depression: treatment outcomes and neural mechanisms. Nature Neuroscience: Reviews, 9, 788-796. PMID: 18784657. 4. Siegle, G.J., Ghinassi, F., Thase, M.E. (2007). Neurobehavioral therapies in the 21st century: Summary of an emerging field and an extended example of Cognitive Control Training for depression. Cognitive Therapy and Research, 31, 235-262.

Innovation Institute 200 Gardner Steel Conference Center Thackeray &O’Hara Streets Pittsburgh, PA 15260 (412) 383-7670 www.innovation.pitt.edu

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