vinyl chloride - IARC Monographs

Agents Classified by the IARC Monographs, Volumes 1–120 CAS No

Agent

Group 0B

Volume

Year1

000075-07-0 Acetaldehyde associated with consumption of alcoholic beverages Acheson process, occupational exposure associated with Acid mists, strong inorganic 001402-68-2 Aflatoxins Alcoholic beverages Aluminium production

1

100E

2012

1 1 1 1 1

2017 2012 2012 2012 2012

000092-67-1 4-Aminobiphenyl

1

Areca nut 000313-67-7 Aristolochic acid (NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data) 000313-67-7 Aristolochic acid, plants containing 007440-38-2 Arsenic and inorganic arsenic compounds

1 1

111 54, 100F 56, 82, 100F 44, 96, 100E 34, Sup 7, 100F 1, Sup 7, 99, 100F 85, 100E 82, 100A

2012 2012

001332-21-4 Asbestos (all forms, including actinolite, amosite, 77536-67-5* anthophyllite, chrysotile, crocidolite, tremolite) (NB: Mineral substances (e.g. talc or vermiculite) that 012172-73-5 contain asbestos should also be regarded as 77536-66-4* carcinogenic to humans.) 012001-29-5 *The presence of an asterisk indicates that the 012001-28-4 registration is for a substance which CAS does not treat in its regular CA index

1

82, 100A 23, Sup 7, 100C 14, Sup 7, 100C

2012

1 1

2012 2012 2012

2012

77536-68-6* Auramine production

1

000446-86-6 Azathioprine

1

000071-43-2 Benzene

1

000092-87-5 Benzidine

1

Benzidine, dyes metabolized to (NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data) 000050-32-8 Benzo[a]pyrene (NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data) 007440-41-7 Beryllium and beryllium compounds Betel quid with tobacco

1

Sup 7, 99, 100F 26, Sup 7, 100A 29, Sup 7. 100F, 120 29, Sup 7, 99, 100F 99, 100F

1

92, 100F

2012

1 1

58, 100C 85, 100E

2012 2012

1

2012 In prep. 2012 2012


Agent

Group 0B

Volume

Year1

Betel quid without tobacco 000542-88-1 Bis(chloromethyl)ether; chloromethyl methyl ether 000107-30-2 (technical-grade)

1 1

85, 100E 4, Sup 7, 100F

2012 2012

000055-98-1 Busulfan

1

2012

000106-99-0 1,3-Butadiene 007440-43-9 Cadmium and cadmium compounds 000305-03-3 Chlorambucil

1 1 1

000494-03-1 Chlornaphazine

1

018540-29-9 Chromium (VI) compounds 059865-13-3 Ciclosporin Clonorchis sinensis (infection with) Coal, indoor emissions from household combustion of Coal gasification 008007-45-2 Coal-tar distillation 065996-93-2 Coal-tar pitch

1 1 1 1 1 1 1

Coke production 000050-18-0 Cyclophosphamide 006055-19-2 059865-13-3 Cyclosporine (see ciclosporin) 079217-60-0 000078-87-5 1,2-Dichloropropane

1 1

4, Sup 7, 100A 97, 100F 58, 100C 26, Sup 7, 100A 4, Sup 7, 100A 49, 100C 50, 100A 61, 100B 95, 100E 92, 100F 92, 100F 35, Sup 7, 100F 92, 100F 26, Sup 7, 100A

2017

000056-53-1 Diethylstilbestrol

1

41, Sup 7, 71, 110 21, Sup 7, 100A

Engine exhaust, diesel Epstein-Barr virus 066733-21-9 Erionite

1 1 1

2014 2012 2012

1

46, 105 70, 100B 42, Sup 7, 100C 72, 100A

1

72, 91, 100A

2012

1

Estrogen-only menopausal therapy Estrogen therapy, postmenopausal (see Estrogen-only menopausal therapy) Estrogen-progestogen menopausal therapy (combined)

2

2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012

2012

2012


000064-17-5 000075-21-8

033419-42-0

033419-42-0 015663-27-1 011056-06-7

Agent

Group 0B

Estrogen-progestogen oral contraceptives (combined) (NB: There is also convincing evidence in humans that these agents confer a protective effect against cancer in the endometrium and ovary) Ethanol in alcoholic beverages Ethylene oxide (NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data) Etoposide (NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data) Etoposide in combination with cisplatin and bleomycin

Fission products, including strontium-90 Fluoro-edenite fibrous amphibole 000050-00-0 Formaldehyde Haematite mining (underground) Helicobacter pylori (infection with) Hepatitis B virus (chronic infection with) Hepatitis C virus (chronic infection with) Human immunodeficiency virus type 1 (infection with) Human papillomavirus types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 (NB: The HPV types that have been classified as carcinogenic to humans can differ by an order of magnitude in risk for cervical cancer) Human T-cell lymphotropic virus type I Ionizing radiation (all types) Iron and steel founding (occupational exposure during)

Volume

1

72, 91, 100A

2012

1 1

96, 100E 97, 100F

2012 2012

1

76, 100A

2012

1

76, 100A

2012

1 1 1 1

100D 111 88, 100F 1, Sup 7, 100D 61, 100B 59, 100B 59, 100B 67, 100B 64, 90, 100B

2012 2017 2012 2012

2012 2012 2012

1 1 1 1 1

Isopropyl alcohol manufacture using strong acids Kaposi sarcoma herpesvirus Leather dust 000058-89-9 Lindane (see also Hexachlorocyclohexanes)

1 1 1 1

67, 100B 100D 34, Sup 7, 100F Sup 7, 100F 70, 100B 100C 113

Magenta production Meat, processed (see Processed meat) 000148-82-3 Melphalan

1

57, 99, 100F

1

9, Sup 7, 100A

3

Year1

1 1 1

2012 2012 2012 2012 2012

2012 2012 2012 In prep. 2012 2012


Agent

Group 0B

000298-81-7 Methoxsalen (8-methoxypsoralen) plus ultraviolet A radiation 013909-09-6 Methyl-CCNU 000101-14-4 4,4'-Methylenebis(2-chloroaniline) (MOCA) (NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data) Mineral oils, untreated or mildly treated

1

MOPP and other combined chemotherapy including alkylating agents 000091-59-8 2-Naphthylamine

1

Volume

Year1

24, Sup 7, 100A Sup 7, 100A 57, 99, 100F

2012

33, Sup 7, 100F Sup 7, 100A

2012

2012

1

4, Sup 7, 99, 100F 75, 100D

1 1

49, 100C 89, 100E

2012 2012

1 1 1 1

61, 100B 109 109 47, 98, 100F

2012 2016 2016 2012

1

100F

2012

1

100F

2012

1

53, 71, 117

000062-44-2 Phenacetin

1

Phenacetin, analgesic mixtures containing 014596-37-3 Phosphorus-32, as phosphate 007440-07-5 Plutonium 001336-36-3 Polychlorinated biphenyls

1 1 1 1

24, Sup 7, 100A Sup 7, 100A 78, 100D 78, 100D 18, Sup 7, 107

In prep. 2012

016543-55-8 064091-91-4

057465-28-8

057117-31-4

000087-86-5

Neutron radiation (NB: Overall evaluation upgraded to Group 1 with supporting evidence from other relevant data) Nickel compounds N'-Nitrosonornicotine (NNN) and 4-(NNitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) (NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data) Opisthorchis viverrini (infection with) Outdoor air pollution Outdoor air pollution, particulate matter in Painter (occupational exposure as a) Particulate matter in outdoor air pollution (see Outdoor air pollution, particulate matter in) 3,4,5,3’,4’-Pentachlorobiphenyl (PCB-126) (see Polychlorinated biphenyls, dioxin-like, with a TEF according to WHO) 2,3,4,7,8-Pentachlorodibenzofuran (NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data) Pentachlorophenol (see also Polychlorophenols)

4

1 1

1

1

2012 2012

2012

2012

2012 2012 2012 2016


013233-32-4 013982-63-3 015262-20-1 010043-92-2

Agent

Group 0B

Volume

Year1

Polychlorinated biphenyls, dioxin-like, with a Toxicity Equivalency Factor (TEF) according to WHO (PCBs 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169, 189) (NB: Overall evaluation upgraded to Group 1 with strong supporting evidence from other relevant data) Processed meat (consumption of)

1

107

2016

1

114

Radioiodines, including iodine-131 Radionuclides, alpha-particle-emitting, internally deposited (NB: Specific radionuclides for which there is sufficient evidence in humans are also listed individually as Group 1 agents) Radionuclides, beta-particle-emitting, internally deposited (NB: Specific radionuclides for which there is sufficient evidence in humans are also listed individually as Group 1 agents) Radium-224 and its decay products Radium-226 and its decay products Radium-228 and its decay products Radon-222 and its decay products Rubber manufacturing industry

1 1

78, 100D 78, 100D

In prep. 2012 2012

1

78, 100D

2012

1 1 1 1 1

78, 100D 78, 100D 78, 100D 43, 78, 100D 28, Sup 7, 100F 56, 100E 61, 100B

2012 2012 2012 2012 2012

2012

2012 2012 2012 2012

Salted fish, Chinese-style Schistosoma haematobium (infection with) 013909-09-6 Semustine (see Methyl-CCNU) 068308-34-9 Shale oils

1 1

014808-60-7 Silica dust, crystalline, in the form of quartz or cristobalite Solar radiation Soot (as found in occupational exposure of chimney sweeps) 000505-60-2 Sulfur mustard

1 1 1

010540-29-1 Tamoxifen (NB: There is also conclusive evidence that tamoxifen reduces the risk of contralateral breast cancer in breast cancer patients) 001746-01-6 2,3,7,8-Tetrachlorodibenzo-para-dioxin 000052-24-4 Thiotepa 007440-29-1 Thorium-232 and its decay products Tobacco, smokeless

1

35, Sup 7, 100F 68, 100C 55, 100D 35, Sup 7, 100F 9, Sup 7, 100F 66, 100A

1 1 1 1

69, 100F 50, 100A 78, 100D 89, 100E

5

1

1

2012 2012

2012 2012 2012 2012 2012


Agent

Group 0B

Tobacco smoke, second-hand Tobacco smoking 000095-53-4 ortho-Toluidine 000299-75-2 Treosulfan

1 1 1 1

000079-01-6 Trichloroethylene Ultraviolet radiation (wavelengths 100-400 nm, encompassing UVA, UVB, and UVC)

1 1

Volume 83, 100E 83, 100E 77, 99, 100F 26, Sup 7, 100A 63, 106 55, 100D*, 118#

Year1 2012 2012 2012 2012 2014 In prep.

*Volume 100D concluded that there is sufficient evidence for ocular melanoma in welders #

Volume 118 concluded that ultraviolet emissions from welding are carcinogenic to humans (Group 1). There is sufficient evidence in humans for the carcinogenicity of ultraviolet emissions from welding)

Ultraviolet-emitting tanning devices 000075-01-4 Vinyl chloride Welding fumes

000079-06-1

023214-92-8

000320-67-2

000154-93-8 064742-93-4 002425-06-1

000075-87-6 000302-17-0

Wood dust X- and Gamma-Radiation Acrylamide (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) Adriamycin (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) Androgenic (anabolic) steroids Art glass, glass containers and pressed ware (manufacture of) Azacitidine (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) Biomass fuel (primarily wood), indoor emissions from household combustion of Bischloroethyl nitrosourea (BCNU) Bitumens, occupational exposure to oxidized bitumens and their emissions during roofing Captafol (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) Carbon electrode manufacture Chloral Chloral hydrate

6

1 1 1

100D 97, 100F 49, 118

2012 2012 In prep.

1 1 2A

62, 100C 75, 100D 60

2012 2012 1994

2A

10, Sup 7

1987

2A 2A

Sup 7 58

1987 1993

2A

50

1990

2A

95

2010

2A 2A

26, Sup 7 103

1987 2013

2A

53

1991

2A 2A 2A

92 63, 106 84, 106

2010 2014 2014


Agent

Group 0B

Volume

Year1

000056-75-7 Chloramphenicol (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 000098-87-3 alpha-Chlorinated toluenes (benzal chloride, 000098-07-7 benzotrichloride, benzyl chloride) and benzoyl chloride (combined exposures) 000100-44-7 000098-88-4 013010-47-4 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 000095-69-2 4-Chloro-ortho-toluidine 054749-90-5 Chlorozotocin (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 015663-27-1 Cisplatin (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 007440-48-4 Cobalt metal with tungsten carbide 012070-12-1 008001-58-9 Creosotes 027208-37-3 Cyclopenta[cd]pyrene (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 000050-29-3 DDT (4,4'-Dichlorodiphenyltrichloroethane)

2A

50

1990

2A

29, Sup 7, 71

1999

2A

26, Sup 7

1987

2A 2A

77, 99 50

2010 1990

2A

26, Sup 7

1987

2A

86

2006

2A 2A

92 92

2010 2010

2A

333-41-5 Diazinon (NB: Overall evaluation upgraded to Group 2A based on mechanistic evidence) 000224-42-0 Dibenz[a,j]acridine (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 000053-70-3 Dibenz[a,h]anthracene (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 000191-30-0 Dibenzo[a,l]pyrene (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 000075-09-2 Dichloromethane (Methylene chloride) 000060-57-1 Dieldrin, and aldrin metabolized to dieldrin 000309-00-2 000064-67-5 Diethyl sulfate (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data)

2A

Sup 7, 53, 113 112

In prep. 2017

2A

32, Sup 7, 103

2013

2A

92

2010

2A

92

2010

2A 2A

71, 110 5, Sup 7, 117

2017 In prep.

2A

54, 71

1999

7


Agent

Group 0B

Volume

Year1

000079-44-7 Dimethylcarbamoyl chloride (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 000068-12-2 N,N-Dimethylformamide

2A

12, Sup 7, 71

1999

2A

47, 71, 115

000540-73-8 1,2-Dimethylhydrazine (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 000077-78-1 Dimethyl sulfate (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 000106-89-8 Epichlorohydrin (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 000051-79-6 Ethyl carbamate (Urethane) 000106-93-4 Ethylene dibromide (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 000759-73-9 N-Ethyl-N-nitrosourea (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) Frying, emissions from high-temperature 000556-52-5 Glycidol (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 001071-83-6 Glyphosate Hairdresser or barber (occupational exposure as a) Human papillomavirus type 68 000302-01-2 Hydrazine

2A

4, Sup 7, 71

In prep. 1999

2A

4, Sup 7, 71

1999

2A

11, Sup 7, 71

1999

2A 2A

7, Sup 7, 96 15, Sup 7, 71

2010 1999

2A

17, Sup 7

1987

2A 2A

95 77

2010 2000

2A 2A 2A 2A

022398-80-7 Indium phosphide (NB: Overall evaluation upgraded to Group 2A) 076180-96-6 IQ (2-Amino-3-methylimidazo[4,5-f]quinoline) (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) Lead compounds, inorganic Malaria (caused by infection with Plasmodium falciparum in holoendemic areas) 000121-75-5 Malathion

2A

112 57, 99 100B 4, Sup 7, 71, 115 86

2017 2010 2012 In prep. 2006

2A

56

1993

2A 2A

87 104

2006 2014

2A

30, Sup 7, 112

2017

2A

115

In prep.

Mate, hot (see Very hot beverages) 000149-30-4 2-Mercaptobenzothiazole

8


Agent

Group 0B

Year1

2A 2A

104 40, Sup 7

2014 1987

2A

7, Sup 7, 71

1999

2A

4, Sup 7

1987

2A

17, Sup 7

1987

2A

94

2010

2A 2A 2A 2A

46, 105 9, Sup 7 46, 105 17, Sup 7

2014 1987 2014 1987

2A

17, Sup 7

1987

2A

101

2013

2A

53

1991

2A 2A

45 108

1989 2016

059536-65-1 Polybrominated biphenyls (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data, namely mechanistic similarity with polychlorinated biphenyls classified in Group 1)

2A

41, Sup 7, 107

2016

000366-70-1 Procarbazine hydrochloride (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data)

2A

26, Sup 7

1987

001120-71-4 1,3-Propane sultone (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data)

2A

4, Sup 7, 71, 110

2017

000484-20-8

000066-27-3

000070-25-7

000684-93-5

007496-02-8 000051-75-2 005522-43-0 000055-18-5

000062-75-9

000088-72-2

111025-46-8

Merkel cell polyomavirus (MCV) 5-Methoxypsoralen (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) Methyl methanesulfonate (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) N-Methyl-N´-nitro-N-nitrosoguanidine (MNNG) (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) N-Methyl-N-nitrosourea (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) Nitrate or nitrite (ingested) under conditions that result in endogenous nitrosation 6-Nitrochrysene Nitrogen mustard 1-Nitropyrene N-Nitrosodiethylamine (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) N-Nitrosodimethylamine (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) 2-Nitrotoluene (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) Non-arsenical insecticides (occupational exposures in spraying and application of) Petroleum refining (occupational exposures in) Pioglitazone

Volume

9


Agent

Group 0B

Volume

Year1

Red meat (consumption of)

2A

114

Shiftwork that involves circadian disruption Silicon carbide whiskers Styrene-7,8-oxide (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) Teniposide (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) Tetrabromobisphenol A

2A 2A 2A

98 111 60

In prep. 2010 2017 1994

2A

76

2000

2A

115

014047-09-7 3,3′,4,4′-Tetrachloroazobenzene (NB: Overall evaluation upgraded to Group 2A) 000127-18-4 Tetrachloroethylene (Perchloroethylene) 000116-14-3 Tetrafluoroethylene (NB: Overall evaluation upgraded to Group 2A) 000096-18-4 1,2,3-Trichloropropane 000126-72-7 Tris(2,3-dibromopropyl) phosphate (NB: Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data) Very hot beverages at above 65 °C (drinking)

2A

117

2A 2A 2A 2A

63, 106 19, Sup 7, 71, 110 63 20, Sup 7, 71

In prep. In prep. 2014 2017

2A

116

000593-60-2 Vinyl bromide (NB: (1) Overall evaluation upgraded to Group 2A based on mechanistic and other relevant data; (2) For practical purposes, vinyl bromide should be considered to act similarly to the human carcinogen vinyl chloride.) 000075-02-5 Vinyl fluoride (NB: (1) Overall evaluation upgraded to Group 2A based on mechanistic and other relevant data; (2) For practical purposes, vinyl fluoride should be considered to act similarly to the human carcinogen vinyl chloride.) 026148-68-5 A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) 000075-07-0 Acetaldehyde 000060-35-5 Acetamide 000107-13-1 Acrylonitrile 003688-53-7 AF-2 [2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide] 006795-23-9 Aflatoxin M1 Aloe vera, whole leaf extract 000060-09-3 para-Aminoazobenzene

2A

39, Sup 7, 71, 97

2A

63, 97

2008

2B 2B 2B 2B 2B 2B 2B 2B

40, Sup 7 36, Sup 7, 71 7, Sup 7, 71 71 31, Sup 7 56 108 8, Sup 7

1987 1999 1999 1999 1987 1993 2016 1987

000409-21-2 000096-09-3

029767-20-2

000079-94-7

10

1995 1999

In prep. 2008


Agent

Group

000097-56-3 000081-49-2 000712-68-5 051264-14-3 000090-04-0 000084-65-1 001309-64-4 000140-57-8 000492-80-8

ortho-Aminoazotoluene 1-Amino-2,4-dibromoanthraquinone 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole Amsacrine ortho-Anisidine Anthraquinone Antimony trioxide Aramite® Auramine

2B 2B 2B 2B 2B 2B 2B 2B 2B

000115-02-6 Azaserine 000151-56-4 Aziridine (NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data) 000202-33-5 Benz[j]aceanthrylene (NB: Overall evaluation upgraded to Group 2B with supporting mechanistic and other relevant data) 000056-55-3 Benz[a]anthracene 000205-99-2 Benzo[b]fluoranthene 000205-82-3 Benzo[j]fluoranthene 000207-08-9 Benzo[k]fluoranthene 000271-89-6 Benzofuran 000195-19-7 Benzo[c]phenanthrene (NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data) 000119-61-9 Benzophenone 001694-09-3 Benzyl violet 4B 003296-90-0 2,2-Bis(bromomethyl)propane-1,3-diol Bitumens, occupational exposure to hard bitumens and their emissions during mastic asphalt work 008052-42-4 Bitumens, occupational exposure to straight-run bitumens 064741-56-6 and their emissions during road paving BK polyomavirus (BKV) 011056-06-7 Bleomycins (NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data) Bracken fern 005589-96-8 Bromochloroacetic acid 000075-27-4 Bromodichloromethane 000106-94-5 1-Bromopropane

0B

11

Volume

Year1 1987 2013 1987 2000 1999 2013 1989 1987 2012

2B 2B

8, Sup 7 101 7, Sup 7 76 73 101 47 5, Sup 7 1, Sup 7, 99, 100F 10, Sup 7 9, Sup 7, 71

2B

92

2010

2B 2B 2B 2B 2B 2B

92 92 92 92 63 92

2010 2010 2010 2010 1995 2010

2B 2B 2B 2B

101 16, Sup 7 77 103

2013 1987 2000 2013

2B

103

2013

2B 2B

104 26, Sup 7

2014 1987

2B 2B 2B 2B

40, Sup 7 101 52, 71 115

1987 2013 1999 In prep.

1987 1999


Agent

Year1

Group

Volume

057018-52-7 1-tert-Butoxypropan-2-ol

2B

88, 119

025013-16-5 003068-88-0 000331-39-5 000086-74-8

2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B

40, Sup 7 11, Sup 7, 71 56 32, Sup 7, 71, 103 65, 93 111 20, Sup 7, 71 25, Sup 7 31, Sup 7 15, Sup 7, 71 79 20, Sup 7 48 48

2B 2B 2B 2B 2B

57 84 73 63 63, 115

2B 2B 2B 2B 2B 2B 2B 2B 2B 2B

41, Sup 7 27, Sup 7 71 73 92 57 57, 99 57 8, Sup 7 52

1993 2004 1999 1995 In prep. 1987 1987 1999 1999 2010 1993 2010 1993 1987 1991

2B 2B 2B 2B

86 86 101 27, Sup 7

2006 2006 2013 1987

0B

Butylated hydroxyanisole (BHA) beta-Butyrolactone Caffeic acid Carbazole

001333-86-4 Carbon black 308068-56-6 Carbon nanotubes, multiwalled MWCNT-7 000056-23-5 Carbon tetrachloride Carpentry and joinery 053973-98-1 Carrageenan, degraded (Poligeenan) 000120-80-9 Catechol 000057-74-9 Chlordane 000143-50-0 Chlordecone (Kepone) 000115-28-6 Chlorendic acid Chlorinated paraffins of average carbon chain length C12 and average degree of chlorination approximately 60% 000106-47-8 para-Chloroaniline 077439-76-0 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone 000067-66-3 Chloroform 000513-37-1 1-Chloro-2-methylpropene 000563-47-3 3-Chloro-2-methylpropene, technical grade

000095-83-0 000126-99-8 001897-45-6 000218-01-9 006459-94-5 000569-61-9 002429-74-5 006358-53-8 007440-48-4 007440-48-4 010026-24-1 068603-42-9 000120-71-8

Chlorophenoxy herbicides 4-Chloro-ortho-phenylenediamine Chloroprene Chlorothalonil Chrysene CI Acid Red 114 CI Basic Red 9 CI Direct Blue 15 Citrus Red No. 2 Cobalt and cobalt compounds (NB: Evaluated as a group) Cobalt metal without tungsten carbide Cobalt sulfate and other soluble cobalt(II) salts Coconut oil diethanolamine condensate para-Cresidine

12

In prep. 1987 1999 1993 2013 2010 2017 1999 1987 1987 1999 2001 1987 1990 1990

Agents Classified by the IARC Monographs, Volumes 1–120 Group

Agent

000098-82-8 014901-08-7 004342-03-4 000117-10-2 020830-81-3

Cumene Cycasin Dacarbazine Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone) Daunomycin

2B 2B 2B 2B 2B

101 10, Sup 7 26, Sup 7 50 10, Sup 7

2013 1987 1987 1990 1987

000613-35-4 000615-05-4 000101-80-4 000095-80-7 000226-36-8

N,N'-Diacetylbenzidine 2,4-Diaminoanisole 4,4'-Diaminodiphenyl ether 2,4-Diaminotoluene Dibenz[a,h]acridine

2B 2B 2B 2B 2B

16, Sup 7 79 29, Sup 7 16, Sup 7 32, Sup 7, 103 103

1987 2001 1987 1987 2013

2013

0B

Volume

Year1

CAS No

000224-53-3 Dibenz[c,h]acridine (NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data) 000194-59-2 7H-Dibenzo[c,g]carbazole

2B

000189-64-0 000189-55-9 000631-64-1 003252-43-5 000096-12-8 000096-13-9 000079-43-6 000106-46-7 000091-94-1 028434-86-8 000107-06-2 000094-75-7

2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B

32, Sup 7, 103 92 92 101 52, 71, 101 20, Sup 7, 71 77 84, 106 73 29, Sup 7 16, Sup 7 20, Sup 7, 71 113

2B 2B 2B 2B

101 41, Sup 7, 71 53 45

2010 2010 2013 2013 1999 2000 2014 1999 1987 1987 1999 2016 online 2013 1999 1991 1989

2B 2B 2B 2B

77, 101 77, 101 4, Sup 7, 71 36, Sup 7, 71

2013 2013 1999 1999

000096-23-1 000542-75-6 000062-73-7

000111-42-2 000117-81-7 001615-80-1 000101-90-6

Dibenzo[a,h]pyrene Dibenzo[a,i]pyrene Dibromoacetic acid Dibromoacetonitrile 1,2-Dibromo-3-chloropropane 2,3-Dibromopropan-1-ol Dichloroacetic acid para-Dichlorobenzene 3,3'-Dichlorobenzidine 3,3'-Dichloro-4,4'-diaminodiphenyl ether 1,2-Dichloroethane 2,4-D (2,4-dichlorophenoxyacetic acid) (see also Chlorophenoxy herbicides) 1,3-Dichloro-2-propanol 1,3-Dichloropropene (technical-grade) Dichlorvos Diesel fuel, marine (NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data) Diethanolamine Di(2-ethylhexyl)phthalate 1,2-Diethylhydrazine Diglycidyl resorcinol ether

13

2B

2013

Agents Classified by the IARC Monographs, Volumes 1–120 Agent

020830-75-5 000094-58-6 002973-10-6 000119-90-4 000060-11-7 025962-77-0

Digoxin Dihydrosafrole Diisopropyl sulfate 3,3'-Dimethoxybenzidine (ortho-Dianisidine) para-Dimethylaminoazobenzene trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2furyl)-vinyl]-1,3,4-oxadiazole 2,6-Dimethylaniline (2,6-Xylidine) Dimethylarsinic acid 3,3'-Dimethylbenzidine (ortho-Tolidine) 1,1-Dimethylhydrazine N,N-Dimethyl-p-toluidine

2B 2B 2B 2B 2B 2B

108 10, Sup 7 54, 71 4, Sup 7 8, Sup 7 7, Sup 7

2016 1987 1999 1987 1987 1987

2B 2B 2B 2B 2B

57 100C 1, Sup 7 4, Sup 7, 71 115

3,7-Dinitrofluoranthene 3,9-Dinitrofluoranthene 1,3-Dinitropyrene 1,6-Dinitropyrene 1,8-Dinitropyrene 2,4-Dinitrotoluene 2,6-Dinitrotoluene 1,4-Dioxane Disperse Blue 1 Dry cleaning (occupational exposures in) Engine exhaust, gasoline 1,2-Epoxybutane (NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data) Ethyl acrylate Ethylbenzene Ethyl methanesulfonate Firefighter (occupational exposure as a) 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole Fuel oils, residual (heavy) Fumonisin B1 Furan Furfuryl alcohol

2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B

46, 65, 105 46, 65, 105 46, 105 46, 105 46, 105 65 65 11, Sup 7, 71 48 63 46, 105 47, 71

1993 2012 1987 1999 In prep. 2014 2014 2014 2014 2014 1996 1996 1999 1990 1995 2014 1999

2B 2B 2B 2B 2B 2B 2B 2B 2B

39, Sup 7, 71 77 7, Sup 7 98 7, Sup 7 45 82 63 119

2B

56

000087-62-7 000075-60-5 000119-93-7 000057-14-7 000099-97-8 105735-71-5 022506-53-2 075321-20-9 042397-64-8 042397-65-9 000121-14-2 000606-20-2 000123-91-1 002475-45-8

000106-88-7

000140-88-5 000100-41-4 000062-50-0 003570-75-0 116355-83-0 000110-00-9 000098-00-0

Group 0B

116355-83-0 Fusarium moniliforme, toxins derived from (fumonisin B1, fumonisin B2, and fusarin C)

14

Volume

Year1

CAS No

1999 2000 1987 2010 1987 1989 2002 1995 In prep. 1993


Agent

Group 0B

Year1

2B

45

1989

2B 2B

108 40, Sup 7

2016 1987

2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B

40, Sup 7 11, Sup 7, 71 108 79 57 79 79 20, Sup 7 73 101 15, Sup 7, 71 67 100B

1987 1999 2016 2001 1993 2001 2001 1987 1999 2013 1999 1996 2012

2B 2B

100B 100B

2012 2012

000058-93-5 Hydrochlorothiazide 000129-43-1 1-Hydroxyanthraquinone Implanted foreign bodies of metallic cobalt, metallic nickel, and an alloy powder containing 66–67% nickel, 13–16% chromium and 7% iron 000193-39-5 Indeno[1,2,3-cd]pyrene 050926-11-9 Indium tin oxide

2B 2B 2B

50, 108 82 74

2016 2002 1999

2B 2B

92 118

009004-66-4 Iron-dextran complex 000078-79-5 Isoprene JC polyomavirus (JCV) 009000-38-8 Kava extract 000303-34-4 Lasiocarpine 007439-92-1 Lead 000632-99-5 Magenta

2B 2B 2B 2B 2B 2B 2B

2, Sup 7 60, 71 104 108 10, Sup 7 23, Sup 7 57, 99, 100F

2010 In prep. 1987 1999 2014 2016 1987 1987 2012

090045-36-6 067730-11-4 067730-10-3 000765-34-4 000126-07-8 002784-94-3 000076-44-8 000118-74-1 000067-72-1 000142-83-6 000680-31-9

Gasoline (NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data) Ginkgo biloba extract Glu-P-1 (2-Amino-6-methyldipyrido[1,2-a:3',2'd]imidazole) Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole) Glycidaldehyde Goldenseal root powder Griseofulvin HC Blue No. 1 Heptachlor Hexachlorobenzene Hexachlorocyclohexanes (see also Lindane) Hexachloroethane 2,4-Hexadienal Hexamethylphosphoramide Human immunodeficiency virus type 2 (infection with) Human papillomavirus types 5 and 8 (in patients with epidermodysplasia verruciformis) Human papillomavirus types 26, 53, 66, 67, 70, 73, 82 Human papillomavirus types 30, 34, 69, 85, 97 (NB: Classified by phylogenetic analogy to the HPV genus alpha types classified in Group 1)

Volume

15


068006-83-7 000071-58-9 077094-11-2 077500-04-0 000108-78-1

Agent

Group 0B

Magnetic fields, extremely low-frequency MeA-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole) Meat, red (see Red meat) Medroxyprogesterone acetate MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) Melamine

Volume

Year1

2B 2B

80 40, Sup 7

2002 1987

2B 2B 2B 2B

1987 1993 1993 In prep. 1987 1999 2012 1999 1987 2010 1987 1987 2013 2013 2013 2013 1993

000531-76-0 Merphalan Metallic implants prepared as thin smooth films 000124-58-3 Methylarsonic acid 000075-55-8 2-Methylaziridine (Propyleneimine) 000592-62-1 Methylazoxymethanol acetate 003697-24-3 5-Methylchrysene 000838-88-0 4,4'-Methylene bis(2-methylaniline) 000101-77-9 4,4'-Methylenedianiline 000093-15-2 Methyleugenol 000693-98-1 2-Methylimidazole 000822-36-6 4-Methylimidazole 000108-10-1 Methyl isobutyl ketone Methylmercury compounds (NB: Evaluated as a group) 000129-15-7 2-Methyl-1-nitroanthraquinone (uncertain purity) 000615-53-2 N-Methyl-N-nitrosourethane 000098-83-9 -Methylstyrene

2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B

21, Sup 7 56 56 Sup 7, 73, 119 9, Sup 7 74 100C 9, Sup 7, 71 10, Sup 7 92 4, Sup 7 39, Sup 7 101 101 101 101 58

2B 2B 2B

27, Sup 7 4, Sup 7 101

1987 1987 2013

000056-04-2 Methylthiouracil 000443-48-1 Metronidazole 000101-61-1 Michler’s base [4,4-methylenebis(N,N-dimethyl)benzenamine] 000090-94-8 Michler’s ketone [4,4-Bis(dimethylamino)benzophenone]

2B 2B 2B

79 13, Sup 7 27, Sup 7, 99

2001 1987 2010

2B

99

2010

101043-37-2 002385-85-5 000050-07-7 065271-80-9 001313-27-5

2B 2B 2B 2B 2B

94 20, Sup 7 10, Sup 7 76 118

2B 2B

101 10, Sup 7

2010 1987 1987 2000 In prep. 2013 1987

Microcystin-LR Mirex Mitomycin C Mitoxantrone Molybdenum trioxide

000096-24-2 3-Monochloro-1,2-propanediol 000315-22-0 Monocrotaline

16


Year1

Group

Volume

003795-88-8 5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)amino]-2oxazolidinone 308068-56-6 Multi-walled carbon nanotubes MWCNT-7 (see Carbon nanotubes, multi-walled MWCNT-7) 000123-35-3 β-Myrcene

2B

7, Sup 7

1987

2B

119

003771-19-5 000091-20-3 007440-02-0 000061-57-4 000139-13-9

2B 2B 2B 2B 2B

24, Sup 7 82 49 13, Sup 7 73

In prep. 1987 2002 1990 1987 1999

2B 2B 2B

16, Sup 7 65 105

1987 1996 2014

2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B

65 30, Sup 7 46, 105 7, Sup 7 7, Sup 7 9, Sup 7 77 29, Sup 7, 71 46, 105 17, Sup 7 17, Sup 7, 77 17, Sup 7 85 17, Sup 7 17, Sup 7 17, Sup 7 17, Sup 7 17, Sup 7 17, Sup 7 56 8, Sup 7 66

1996 1987 2014 1987 1987 1987 2000 1999 2014 1987 2000 1987 2004 1987 1987 1987 1987 1987 1987 1993 1987 1996

000602-87-9 000091-23-6 017117-34-9

000098-95-3 001836-75-5 000607-57-8 000555-84-0 000531-82-8 000126-85-2 000075-52-5 000079-46-9 057835-92-4 000924-16-3 001116-54-7 000621-64-7 060153-49-3 010595-95-6 004549-40-0 000059-89-2 000100-75-4 000930-55-2 013256-22-9 000303-47-9 002646-17-5 000604-75-1

Agent 0B

Nafenopin Naphthalene Nickel, metallic and alloys Niridazole Nitrilotriacetic acid and its salts (NB: Evaluated as a group) 5-Nitroacenaphthene 2-Nitroanisole 3-Nitrobenzanthrone (NB: Overall evaluation upgraded to Group 2B with supporting evidence from other relevant data) Nitrobenzene Nitrofen (technical-grade) 2-Nitrofluorene 1-[(5-Nitrofurfurylidene)amino]-2-imidazolidinone N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide Nitrogen mustard N-oxide Nitromethane 2-Nitropropane 4-Nitropyrene N-Nitrosodi-n-butylamine N-Nitrosodiethanolamine N-Nitrosodi-n-propylamine 3-(N-Nitrosomethylamino)propionitrile N-Nitrosomethylethylamine N-Nitrosomethylvinylamine N-Nitrosomorpholine N-Nitrosopiperidine N-Nitrosopyrrolidine N-Nitrososarcosine Ochratoxin A Oil Orange SS Oxazepam

17


Agent

Group 0B

012174-11-7 Palygorskite (Attapulgite) (long fibres, > 5 micrometres) 000794-93-4 Panfuran S (containing dihydroxymethylfuratrizine) 000056-38-2 Parathion

2B 2B 2B

037319-17-8 Pentosan polysulfate sodium 000335-67-1 Perfluorooctanoic acid (PFOA) 000136-40-3 000050-06-6 000077-09-8 000063-92-3 000122-60-1 000057-41-0 105650-23-5

003564-09-8 003761-53-3 007758-01-2 000125-33-7

000057-57-8 000075-56-9 000051-52-5 000089-82-7 000110-86-1

Phenazopyridine hydrochloride Phenobarbital Phenolphthalein Phenoxybenzamine hydrochloride Phenyl glycidyl ether Phenytoin PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) Pickled vegetables (traditional Asian) Polychlorophenols and their sodium salts (mixed exposures) (see also Pentachlorophenol; 2,4,6Trichlorophenol) Polymeric implants prepared as thin smooth films (with the exception of poly(glycolic acid)) Ponceau 3R Ponceau MX Potassium bromate Primidone Printing processes (occupational exposures in) Progestins Progestogen-only contraceptives beta-Propiolactone Propylene oxide Propylthiouracil Pulegone Pyridine

Radiofrequency electromagnetic fields2 Refractory ceramic fibres 023246-96-0 Riddelliine 000094-59-7 Safrole Schistosoma japonicum (infection with) 308076-74-6 Silicon carbide, fibrous

0F2

18

Volume

Year1 1997 1987 2017

2B 2B

68 24, Sup 7 30, Sup 7, 112 108 110

2B 2B 2B 2B 2B 2B 2B 2B 2B

24, Sup 7 79 76 24, Sup 7 47, 71 66 56 56 53, 71

1987 2001 2000 1987 1999 1996 1993 1993 1999

2B

74

1999

2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B

8, Sup 7 8, Sup 7 73 108 65 Sup 7 72 4, Sup 7, 71 60 79 108 77, 119

2B 2B 2B 2B 2B 2B

102 43, 81 10, Sup 7, 82 10, Sup 7 61 111

1987 1987 1999 2016 1996 1987 1999 1999 1994 2001 2016 In prep. 2013 2002 2002 1987 1994 2017

2016 2017


Agent

Group 0B

Volume

Year1

000132-27-4 Sodium ortho-phenylphenate Special-purpose fibres such as E-glass and '475' glass fibres 010048-13-2 Sterigmatocystin 018883-66-4 Streptozotocin 000100-42-5 Styrene 000095-06-7 Sulfallate 000599-79-1 Sulfasalazine Surgical implants (see Implanted foreign bodies, Metallic implants, Polymeric implants) 014807-96-6 Talc-based body powder (perineal use of) 000630-20-6 1,1,1,2-Tetrachloroethane

2B 2B

73 81

1999 2002

2B 2B 2B 2B 2B

10, Sup 7 17, Sup 7 60, 82 30, Sup 7 108

1987 1987 2002 1987 2016

2B 2B

2010 2014

000079-34-5 1,1,2,2-Tetrachloroethane

2B

93 41, Sup 7, 71, 106 20, Sup 7, 71, 106

022248-79-9 Tetrachlorvinphos

2B

2017

000109-99-9 Tetrahydrofuran

2B

30, Sup 7, 112 119

000509-14-8 Tetranitromethane Textile manufacturing industry (work in) 000062-55-5 Thioacetamide 000139-65-1 4,4'-Thiodianiline 000141-90-2 Thiouracil 013463-67-7 Titanium dioxide 026471-62-5 Toluene diisocyanates 008001-35-2 Toxaphene (Polychlorinated camphenes) 000396-01-0 Triamterene 000817-09-4 Trichlormethine (Trimustine hydrochloride) 000076-03-9 Trichloroacetic acid 000088-06-2 2,4,6-Trichlorophenol (see also Polychlorophenols)

2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B 2B

65 48 7, Sup 7 27, Sup 7 79 47, 93 39, Sup 7, 71 79 108 50 84, 106 117

062450-06-0 062450-07-1 000072-57-1 000066-75-1 001314-62-1 000108-05-4 000100-40-3

2B 2B 2B 2B 2B 2B 2B

31, Sup 7 31, Sup 7 8, Sup 7 9, Sup 7 86 63 60

Trp-P-1 (3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole) Trp-P-2 (3-Amino-1-methyl-5H-pyrido[4,3-b]indole) Trypan blue Uracil mustard Vanadium pentoxide Vinyl acetate 4-Vinylcyclohexene

19

2014

In prep. 1996 1990 1987 1987 2001 2010 1999 2001 2016 1990 2014 In prep. 1987 1987 1987 1987 2006 1995 1994


Agent

Group 0B

000106-87-6 4-Vinylcyclohexene diepoxide 000075-35-4 Vinylidene chloride

2B 2B

007481-89-2 030516-87-1 000083-32-9 025732-74-5 059277-89-3 000494-38-2 008018-07-3 000107-02-8 000079-10-7

2B 2B 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

000050-76-0 002757-90-6 000116-06-3 000107-05-1 000057-06-7 002835-39-4 000915-67-3 004657-93-6 000117-79-3 000150-13-0 000082-28-0 000099-57-0 000121-88-0 000119-34-6 000121-66-4 002432-99-7 000061-82-5

000069-53-4 000523-50-2 000062-53-3 000104-94-9 000191-26-4

Zalcitabine Zidovudine (AZT) Acenaphthene Acepyrene (3,4-dihydrocyclopenta[cd]pyrene) Aciclovir Acridine orange Acriflavinium chloride Acrolein Acrylic acid Acrylic fibres Acrylonitrile-butadiene-styrene copolymers Actinomycin D Agaritine Aldicarb Allyl chloride Allyl isothiocyanate Allyl isovalerate Amaranth 5-Aminoacenaphthene 2-Aminoanthraquinone para-Aminobenzoic acid 1-Amino-2-methylanthraquinone 2-Amino-4-nitrophenol 2-Amino-5-nitrophenol 4-Amino-2-nitrophenol 2-Amino-5-nitrothiazole 11-Aminoundecanoic acid Amitrole (NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data) Ampicillin Anaesthetics, volatile Angelicin plus ultraviolet A radiation Aniline para-Anisidine Anthanthrene

20

3 3 3 3 3 3

Volume

Year1

60 39, Sup 7, 71, 119 76 76 92 92 76 16, Sup 7 13, Sup 7 63 19, Sup 7, 71 19, Sup 7 19, Sup 7 10, Sup 7 31, Sup 7 53 36, Sup 7, 71 73 36, Sup 7, 71 8, Sup 7 16, Sup 7 27, Sup 7 16, Sup 7 27, Sup 7 57 57 16, Sup 7 31, Sup 7 39, Sup 7 79

1994 In prep. 2000 2000 2010 2010 2000 1987 1987 1995 1999 1987 1987 1987 1987 1991 1999 1999 1999 1987 1987 1987 1987 1987 1993 1993 1987 1987 1987 2001

50 11, Sup 7 40, Sup 7 27, Sup 7 27, Sup 7 92

1990 1987 1987 1987 1987 2010


Agent

000120-12-7 000118-92-3 001345-04-6 000052-46-0 024938-64-5 064436-13-1

Anthracene Anthranilic acid Antimony trisulfide Apholate para-Aramid fibrils Arsenobetaine and other organic arsenic compounds that are not metabolized in humans Atrazine (NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data) Aurothioglucose 2-(1-Aziridinyl)ethanol Aziridyl benzoquinone Azobenzene 11H-Benz[bc]aceanthrylene Benz[l]aceanthrylene Benz[a]acridine

001912-24-9

012192-57-3 001072-52-2 000800-24-8 000103-33-3 000202-94-8 000211-91-6 000225-11-6

Group 0B

92 16, Sup 7 47 9, Sup 7 68 100C

2010 1987 1989 1987 1997 2012

3

73

1999

3 3 3 3 3 3 3

13, Sup 7 9, Sup 7 9, Sup 7 8, Sup 7 92 92 32, Sup 7, 103 32, Sup 7, 103 92 92 92 92 92 92 92 103 92 92 29, Sup 7, 71 36, Sup 7, 71 40, Sup 7, 71 9, Sup 7 9, Sup 7, 71 15; Sup 7, 71 15; Sup 7, 71 41, Sup 7, 71 47, 71

1987 1987 1987 1987 2010 2010 2013

3

000214-17-5 000196-78-1 000203-33-8 000203-12-3 000238-84-6 000243-17-4 000205-12-9 000239-35-0 000191-24-2 000192-97-2 000105-11-3 000094-36-0 000140-11-4 002168-68-5 000111-44-4 013483-18-6 056894-91-8 000108-60-1 002386-90-5

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

21

Year1

3 3 3 3 3 3

000225-51-4 Benz[c]acridine Benzo[b]chrysene Benzo[g]chrysene Benzo[a]fluoranthene Benzo[ghi]fluoranthene Benzo[a]fluorene Benzo[b]fluorene Benzo[c]fluorene Benzo[b]naphtho[2,1-d]thiophene Benzo[ghi]perylene Benzo[e]pyrene para-Benzoquinone dioxime Benzoyl peroxide Benzyl acetate Bis(1-aziridinyl)morpholinophosphine sulfide Bis(2-chloroethyl)ether 1,2-Bis(chloromethoxy)ethane 1,4-Bis(chloromethoxymethyl)benzene Bis(2-chloro-1-methylethyl)ether Bis(2,3-epoxycyclopentyl)ether

Volume

2013 2010 2010 2010 2010 2010 2010 2010 2013 2010 2010 1999 1999 1999 1987 1999 1999 1999 1999 1999


Agent

Group 0B

Volume

Year1

001675-54-3 Bisphenol A diglycidyl ether (Araldite ) Bisulfites 000129-17-9 Blue VRS 003844-45-9 Brilliant Blue FCF, disodium salt 083463-62-1 Bromochloroacetonitrile 000074-96-4 Bromoethane 000075-25-2 Bromoform 000111-76-2 2-Butoxyethanol

3 3 3 3 3 3 3 3

47, 71 54 16, Sup 7 16, Sup 7 52, 71 52, 71 52, 71 88

1999 1992 1987 1987 1999 1999 1999 2006

000141-32-2 000128-37-0 000085-68-7 000096-48-0 000058-08-2

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

39, Sup 7, 71 40, Sup 7 73 11, Sup 7, 71 51 92 10, Sup 7 30, Sup 7 12, Sup 7 40, Sup 7 111 111 8, Sup 7 31, Sup 7 74 84 30, Sup 7 52 52, 71 30, Sup 7 52, 71 41, Sup 7, 71 52, 71 41, Sup 7, 71

1999 1987 1999 1999 1991 2010 1987 1987 1987 1987 2017 2017 1987 1987 1999 2004 1987 1991 1999 1987 1999 1999 1999 1999

3

65

1996

3

27, Sup 7

1987

000056-25-7 000133-06-2 000063-25-2 020073-24-9 308068-56-6 308068-56-6 003567-69-9 009000-07-1 010599-90-3 006164-98-3 000107-14-2 000510-15-6 000124-48-1 000075-45-6 000075-00-3 000593-70-4

n-Butyl acrylate Butylated hydroxytoluene (BHT) Butyl benzyl phthalate gamma-Butyrolactone Caffeine Calcium carbide production Cantharidin Captan Carbaryl 3-Carbethoxypsoralen Carbon nanotubes, multiwalled, other than MWCNT-7 Carbon nanotubes, single-walled Carmoisine Carrageenan, native Ceramic implants Chloramine Chlordimeform Chlorinated drinking-water Chloroacetonitrile Chlorobenzilate Chlorodibromomethane Chlorodifluoromethane Chloroethane Chlorofluoromethane

000088-73-3 Chloronitrobenzenes 000121-73-3 000100-00-5 005131-60-2 4-Chloro-meta-phenylenediamine

22


Agent

000101-21-3 000054-05-7 000095-79-4 000075-88-7 000057-88-5 007440-47-3 016065-83-1 000532-82-1 006373-74-6 000523-44-4 001936-15-8 002425-85-6 051481-61-9 000087-29-6 000518-75-2 000637-07-0 000050-41-9

Chloropropham Chloroquine 5-Chloro-ortho-toluidine 2-Chloro-1,1,1-trifluoroethane Cholesterol Chromium, metallic Chromium (III) compounds Chrysoidine CI Acid Orange 3 CI Acid Orange 20 CI Orange G CI Pigment Red 3 Cimetidine Cinnamyl anthranilate Citrinin Clofibrate Clomiphene citrate Coal dust Coffee (drinking) (NB: There is evidence suggesting lack of carcinogenicity in humans of coffee drinking for cancers of the pancreas, liver, female breast, uterine endometrium, and prostate. Inverse associations with coffee drinking have been observed with cancers of the liver and uterine endometrium.) Copper 8-hydroxyquinoline Coronene Coumarin meta-Cresidine Crotonaldehyde Crude oil Cyclamates (sodium cyclamate) Cyclochlorotine Cyclohexanone 4H-Cyclopenta[def]chrysene 5,6-Cyclopenteno-1,2-benzanthracene D & C Red No. 9 Dapsone Decabromodiphenyl oxide Deltamethrin

010380-28-6 000191-07-1 000091-64-5 000102-50-1 004170-30-3 008002-05-9 000139-05-9 012663-46-6 000108-94-1 000202-98-2 007099-43-6 005160-02-1 000080-08-0 001163-19-5 052918-63-5

Group 0B

23

Volume

Year1

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

12, Sup 7 13, Sup 7 77, 99 41, Sup 7, 71 31, Sup 7 49 49 8, Sup 7 57 8, Sup 7 8, Sup 7 57 50 77 40, Sup 7 66 21, Sup 7 68 51, 116

1987 1987 2010 1999 1987 1990 1990 1987 1993 1987 1987 1993 1990 2000 1987 1996 1987 1997 In prep.

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

15, Sup 7 32, Sup 7 77 27, Sup 7 63 45 73 10, Sup 7 47, 71 92 92 57 24, Sup 7 48, 71 53

1987 1987 2000 1987 1995 1989 1999 1987 1999 2010 2010 1993 1987 1999 1991


000083-63-6 002303-16-4 000099-56-9 005307-14-2 000095-70-5 000439-14-5 000334-88-3 000215-58-7 000224-41-9 000262-12-4 005385-75-1 000207-83-0 000192-47-2 000192-65-4 000192-51-8 000132-65-0 003018-12-0 007572-29-4 000541-73-1 000095-50-1 000110-57-6 000609-20-1 000115-32-2 069655-05-6 000103-23-1 000105-55-5 000641-48-5 000794-93-4 000828-00-2 000091-93-0 000140-56-7 022975-76-4 004063-41-6 000121-69-7 000868-85-9 022349-59-3

Agent

Group 0B

Dental materials Diacetylaminoazotoluene Diallate 1,2-Diamino-4-nitrobenzene 1,4-Diamino-2-nitrobenzene 2,5-Diaminotoluene Diazepam Diazomethane Dibenz[a,c]anthracene Dibenz[a,j]anthracene Dibenzo-para-dioxin Dibenzo[a,e]fluoranthene 13H-Dibenzo[a,g]fluorene Dibenzo[h,rst]pentaphene Dibenzo[a,e]pyrene Dibenzo[e,l]pyrene Dibenzothiophene Dichloroacetonitrile Dichloroacetylene meta-Dichlorobenzene ortho-Dichlorobenzene trans-1,4-Dichlorobutene 2,6-Dichloro-para-phenylenediamine Dicofol Didanosine Diesel fuels, distillate (light) Di(2-ethylhexyl) adipate N,N'-Diethylthiourea Dihydroaceanthrylene Dihydroxymethylfuratrizine (see also Panfuran S) Dimethoxane 3,3'-Dimethoxybenzidine-4,4'-diisocyanate para-Dimethylaminoazobenzenediazo sodium sulfonate 4,4'-Dimethylangelicin plus ultraviolet A radiation 4,5'-Dimethylangelicin plus ultraviolet A radiation N,N-Dimethylaniline Dimethyl hydrogen phosphite 1,4-Dimethylphenanthrene

24

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

Volume 74 8, Sup 7 30, Sup 7 16, Sup 7 57 16, Sup 7 66 7, Sup 7 92 92 69 92 92 92 92 92 103 52, 71 39, Sup 7, 71 73 73 15, Sup 7, 71 39, Sup 7 30, Sup 7 76 45 77 79 92 24, Sup 7 15, Sup 7 39, Sup 7 8, Sup 7 Sup 7 Sup 7 57 48, 71 92

Year1 1999 1987 1987 1987 1993 1987 1996 1987 2010 2010 1997 2010 2010 2010 2010 2010 2013 1999 1999 1999 1999 1999 1987 1987 2000 1989 2000 2001 2010 1987 1987 1987 1987 1987 1987 1993 1999 2010


Agent

000101-25-7 000618-85-9 000492-17-1 002832-40-8 000097-77-8 001143-38-0 040762-15-0 000562-10-7 082413-20-5 000150-69-6

Dinitrosopentamethylenetetramine 3,5-Dinitrotoluene 2,4'-Diphenyldiamine Disperse Yellow 3 Disulfiram Dithranol Doxefazepam Doxylamine succinate Droloxifene Dulcin Electric fields, extremely low-frequency Electric fields, static Endrin Eosin 3,4-Epoxy-6-methylcyclohexylmethyl-3,4-epoxy-6methylcyclo-hexanecarboxylate cis-9,10-Epoxystearic acid Estazolam Ethionamide Ethylene Ethylene sulfide Ethylenethiourea (NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data) 2-Ethylhexyl acrylate Ethyl selenac Ethyl tellurac Eugenol Evans blue Fast Green FCF Fenvalerate Ferbam Ferric oxide Flat-glass and specialty glass (manufacture of) Fluometuron Fluoranthene Fluorene Fluorescent lighting Fluorides (inorganic, used in drinking-water)

000072-20-8 015086-94-9 000141-37-7 024560-98-3 029975-16-4 000536-33-4 000074-85-1 000420-12-2 000096-45-7

000103-11-7 005456-28-0 020941-65-5 000097-53-0 000314-13-6 002353-45-9 051630-58-1 014484-64-1 001309-37-1 002164-17-2 000206-44-0 000086-73-7 016984-48-8

Group 0B

25

Volume

Year1

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

11, Sup 7 65 16, Sup 7 48 12, Sup 7 13; Sup 7 66 79 66 12, Sup 7 80 80 5, Sup 7 15, Sup 7 11, Sup 7, 71

1987 1996 1987 1990 1987 1987 1996 2001 1996 1987 2002 2002 1987 1987 1999

3 3 3 3 3 3

11, Sup 7, 71 66 13, Sup 7 60 11, Sup 7 79

1999 1996 1987 1994 1987 2001

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

60 12, Sup 7 12, Sup 7 36, Sup 7 8, Sup 7 16, Sup 7 53 12, Sup 7 1, Sup 7 58 30, Sup 7 92 92 55 27, Sup 7

1994 1987 1987 1987 1987 1987 1991 1987 1987 1993 1987 2010 2010 1992 1987


Agent

Group 0B

000051-21-8 5-Fluorouracil Foreign bodies (see Ceramic implants, Dental materials, Implanted foreign bodies, Organic polymeric materials, Orthopaedic implants, Silicone breast implants) Fuel oils, distillate (light) 000067-45-8 Furazolidone 000098-01-1 Furfural 000054-31-9 Furosemide (Frusemide) Fusarium graminearum, F. culmorum, and F. crookwellense, toxins derived from (zearalenone, deoxynivalenol, nivalenol, and fusarenone X) Fusarium sporotrichioides, toxins derived from (T-2 toxin) 025812-30-0 Gemfibrozil Glass filament, continuous 005431-33-4 Glycidyl oleate 007460-84-6 Glycidyl stearate 004680-78-8 Guinea Green B 016568-02-8 Gyromitrin 001317-60-8 Haematite Hair colouring products (personal use of) 033229-34-4 HC Blue No. 2 002871-01-4 HC Red No. 3 059820-43-8 HC Yellow No. 4 Hepatitis D virus 000087-68-3 Hexachlorobutadiene 000070-30-4 Hexachlorophene Human papillomavirus genus beta (except types 5 and 8) and genus gamma Human papillomavirus types 6 and 11 Human T-cell lymphotropic virus type II 023255-93-8 Hycanthone mesylate 000086-54-4 Hydralazine 007647-01-0 Hydrochloric acid 007722-84-1 Hydrogen peroxide 000123-31-9 Hydroquinone 001689-82-3 4-Hydroxyazobenzene 000148-24-3 8-Hydroxyquinoline 026782-43-4 Hydroxysenkirkine 000127-07-1 Hydroxyurea

26

Volume

Year1

3

26, Sup 7

1987

3 3 3 3 3

45 31, Sup 7 63 50 56

1989 1987 1995 1990 1993

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

56 66 43, 81 11, Sup 7 11, Sup 7 16, Sup 7 31, Sup 7 1, Sup 7 57, 99 57 57 57 59 73 20, Sup 7 90, 100B

1993 1996 2002 1987 1987 1987 1987 1987 2010 1993 1993 1993 1994 1999 1987 2012

3 3 3 3 3 3 3 3 3 3 3

90, 100B 67 13, Sup 7 24, Sup 7 54 36, Sup 7, 71 15, Sup 7, 71 8, Sup 7 13, Sup 7 10, Sup 7 76

2012 1996 1987 1987 1992 1999 1999 1987 1987 1987 2000


009004-51-7 001338-16-5 015503-86-3 000054-85-3 003778-73-2 000067-63-0 000120-58-1 006870-67-3 000520-18-3 000501-30-4 000105-74-8

005141-20-8 005989-27-5

021884-44-6

000123-33-1 000542-78-9 012427-38-2 000551-74-6

Agent

Group 0B

Hypochlorite salts Implanted foreign bodies of metallic chromium or titanium and of cobalt-based, chromium-based, and titaniumbased alloys, stainless steel, and depleted uranium Insulation glass wool Iron-dextrin complex Iron sorbitol-citric acid complex Isatidine Isonicotinic acid hydrazide (Isoniazid) Isophosphamide Isopropyl alcohol Isopropyl oils Isosafrole Jacobine Jet fuel Kaempferol Kojic acid Lauroyl peroxide Lead compounds, organic (NB: Organic lead compounds are metabolized at least in part, to ionic lead both in humans and animals. To the extent that ionic lead, generated from organic lead, is present in the body, it will be expected to exert the toxicities associated with inorganic lead.) Leather goods manufacture Leather tanning and processing Light Green SF d-Limonene (NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data) Lumber and sawmill industries (including logging) Luteoskyrin Madder root (Rubia tinctorum) Magnetic fields, static Maleic hydrazide Malonaldehyde Maneb Mannomustine dihydrochloride Maté, not very hot (drinking)

27

Volume

Year1

3 3

52 74

1991 1999

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

43, 81 2, Sup 7 2, Sup 7 10, Sup 7 4, Sup 7 26, Sup 7 15, Sup 7, 71 15, Sup 7, 71 10, Sup 7 10, Sup 7 45 31, Sup 7 79 36, Sup 7, 71 23, Sup 7, 87

2002 1987 1987 1987 1987 1987 1999 1999 1987 1987 1989 1987 2001 1999 2006

3 3 3 3

25, Sup 7 25, Sup 7 16, Sup 7 73

1987 1987 1987 1999

3 3 3 3 3 3 3 3 3

25, Sup 7 10, Sup 7 82 80 4, Sup 7 36, Sup 7, 71 12, Sup 7 9, Sup 7 51, 116

1987 1987 2002 2002 1987 1999 1987 1987 In prep.


Agent

Year1

Group

Volume

013045-94-8 Medphalan

3

9, Sup 7

1987

000050-44-2 6-Mercaptopurine 007439-97-6 Mercury and inorganic mercury compounds Metabisulfites 000060-56-0 Methimazole 000059-05-2 Methotrexate 000072-43-5 Methoxychlor 000096-33-3 Methyl acrylate 073459-03-7 5-Methylangelicin plus ultraviolet A radiation 000074-83-9 Methyl bromide 001634-04-4 Methyl tert-butyl ether 000598-55-0 Methyl carbamate 000074-87-3 Methyl chloride 003351-28-8 1-Methylchrysene 003351-32-4 2-Methylchrysene 003351-31-3 3-Methylchrysene 003351-30-2 4-Methylchrysene 001705-85-7 6-Methylchrysene 000099-80-9 N-Methyl-N,4-dinitrosoaniline 007220-79-3 Methylene blue 000101-68-8 4,4'-Methylenediphenyl diisocyanate 033543-31-6 2-Methylfluoranthene 001706-01-0 3-Methylfluoranthene 000078-98-8 Methylglyoxal 000074-88-4 Methyl iodide 000080-62-6 Methyl methacrylate 090456-67-0 N-Methylolacrylamide 000298-00-0 Methyl parathion 000832-69-9 1-Methylphenanthrene 085878-63-3 7-Methylpyrido[3,4-c]psoralen 000493-52-7 Methyl red 000144-34-3 Methyl selenac Microcystis extracts Mineral oils, highly-refined Modacrylic fibres 000150-68-5 Monuron

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

26, Sup 7 58 54 79 26, Sup 7 20, Sup 7 39, Sup 7, 71 Sup 7 41, Sup 7, 71 73 12, Sup 7 41, Sup 7, 71 92 92 92 92 92 1, Sup 7 108 19, Sup 7, 71 92 92 51 41, Sup 7, 71 60 60 30, Sup 7 92 40, Sup 7 8, Sup 7 12, Sup 7 94 33, Sup 7 19, Sup 7 53

1987 1993 1992 2001 1987 1987 1999 1987 1999 1999 1987 1999 2010 2010 2010 2010 2010 1987 2016 1999 2010 2010 1991 1999 1994 1994 1987 2010 1987 1987 1987 2010 1987 1987 1991

0B

28


Agent

000110-91-8 Morpholine 308068-56-6 Multiwalled carbon nanotubes other than MWCNT-7 (see Carbon nanotubes, multiwalled, other than MWCNT-7) 000083-66-9 Musk ambrette 000081-15-2 Musk xylene 002243-62-1 1,5-Naphthalenediamine 003173-72-6 1,5-Naphthalene diisocyanate 111189-32-3 Naphtho[1,2-b]fluoranthene 000203-20-3 Naphtho[2,1-a]fluoranthene 000193-09-9 Naphtho[2,3-e]pyrene 000134-32-7 1-Naphthylamine 000086-88-4 1-Naphthylthiourea (ANTU) 000139-94-6 Nithiazide 000099-59-2 5-Nitro-ortho-anisidine 000602-60-8 9-Nitroanthracene 020268-51-3 7-Nitrobenz[a]anthracene 063041-90-7 6-Nitrobenzo[a]pyrene 000092-93-3 4-Nitrobiphenyl 000892-21-7 3-Nitrofluoranthene 000059-87-0 Nitrofural (Nitrofurazone) 000067-20-9 Nitrofurantoin 000086-57-7 1-Nitronaphthalene 000581-89-5 2-Nitronaphthalene 020589-63-3 3-Nitroperylene 000789-07-1 2-Nitropyrene 037620-20-5 N'-Nitrosoanabasine (NAB) 071267-22-6 N'-Nitrosoanatabine (NAT) 000086-30-6 N-Nitrosodiphenylamine 000156-10-5 para-Nitrosodiphenylamine 029291-35-8 N-Nitrosofolic acid 055557-01-2 N-Nitrosoguvacine 055557-02-3 N-Nitrosoguvacoline 030310-80-6 N-Nitrosohydroxyproline 085502-23-4 3-(N-Nitrosomethylamino)propionaldehyde 007519-36-0 N-Nitrosoproline 000099-08-1 Nitrotoluenes 000099-99-0 000099-55-8 5-Nitro-ortho-toluidine

29

Year1

Group

Volume

3

47, 71

1999

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

65 65 27, Sup 7 19, Sup 7, 71 92 92 92 4, Sup 7 30, Sup 7 31, Sup 7 27, Sup 7 33, Sup 7 46 46 4, Sup 7 33, Sup 7 50 50 46 46 46 46 37, Sup 7, 89 37, Sup 7, 89 27, Sup 7 27, Sup 7 17, Sup 7 85 85 17, Sup 7 85 17, Sup 7 65

1996 1996 1987 1999 2010 2010 2010 1987 1987 1987 1987 1987 1989 1989 1987 1987 1990 1990 1989 1989 1989 1989 2007 2007 1987 1987 1987 2004 2004 1987 2004 1987 1996

3

48

1990

0B


Agent

000804-36-4 118399-22-7 025038-54-4 022966-79-6

Nitrovin Nodularins Nylon 6 Oestradiol mustard Opisthorchis felineus (infection with) Organic polymeric materials Orthopaedic implants of complex composition and cardiac pacemakers Oxyphenbutazone Paint manufacture (occupational exposure in) Palygorskite (Attapulgite)(short fibres, < 5 micrometres) Paracetamol (Acetaminophen) Parasorbic acid Patulin Penicillic acid Pentachloroethane Permethrin Perylene Petasitenine Petroleum solvents Phenanthrene Phenelzine sulfate Phenicarbazide Phenol Phenylbutazone meta-Phenylenediamine para-Phenylenediamine N-Phenyl-2-naphthylamine ortho-Phenylphenol Picene Picloram Piperonyl butoxide Polyacrylic acid Polychlorinated dibenzo-para-dioxins (other than 2,3,7,8tetrachlorodibenzo-para-dioxin) Polychlorinated dibenzofurans (see 2,3,4,7,8-Pentachlorodibenzofuran) Polychloroprene Polyethylene

000129-20-4 012174-11-7 000103-90-2 010048-32-5 000149-29-1 000090-65-3 000076-01-7 052645-53-1 000198-55-0 060102-37-6 000085-01-8 000156-51-4 000103-03-7 000108-95-2 000050-33-9 000108-45-2 000106-50-3 000135-88-6 000090-43-7 000213-46-7 001918-02-1 000051-03-6 009003-01-4

009010-98-4 009002-88-4

Group 0B

30

Volume

Year1

3 3 3 3 3 3 3

31, Sup 7 94 19, Sup 7 9, Sup 7 61 74 74

1987 2010 1987 1987 1994 1999 1999

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

13, Sup 7 47 68 73 10, Sup 7 40, Sup 7 10, Sup 7 41, Sup 7, 71 53 92 31, Sup 7 47 92 24, Sup 7 12, Sup 7 47, 71 13, Sup 7 16, Sup 7 16, Sup 7 16, Sup 7 73 92 53 30, Sup 7 19, Sup 7 69

1987 1989 1997 1999 1987 1987 1987 1999 1991 2010 1987 1989 2010 1987 1987 1999 1987 1987 1987 1987 1999 2010 1991 1987 1987 1997

3

69

1997

3 3

19, Sup 7 19, Sup 7

1987 1987


009016-87-9 009011-14-7 009003-07-0 009003-53-6 009002-84-0 009009-54-5 009003-20-7 009002-89-5 009002-86-2 009003-39-8 004548-53-2 023746-34-1 002955-38-6 029069-24-7 000053-03-2

000129-00-0

Polymethylene polyphenyl isocyanate Polymethyl methacrylate Polypropylene Polystyrene Polytetrafluoroethylene Polyurethane foams Polyvinyl acetate Polyvinyl alcohol Polyvinyl chloride Polyvinyl pyrrolidone Ponceau SX Potassium bis(2-hydroxyethyl)dithiocarbamate Prazepam Prednimustine Prednisone Printing inks Proflavine salts Pronetalol hydrochloride Propham n-Propyl carbamate Propylene Ptaquiloside Pulp and paper manufacture Pyrene

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

19, Sup 7 19, Sup 7 19, Sup 7 19, Sup 7 19, Sup 7 19, Sup 7 19, Sup 7 19, Sup 7 19, Sup 7 19, Sup 7, 71 8, Sup 7 12, Sup 7 66 50 26, Sup 7 65 24, Sup 7 13, Sup 7 12, Sup 7 12, Sup 7 60 40, Sup 7 25, Sup 7 92

1987 1987 1987 1987 1987 1987 1987 1987 1987 1987 1987 1987 1996 1990 1987 1996 1987 1987 1987 1987 1994 1987 1987 2010

085878-62-2 000058-14-0 000117-39-5 000106-51-4 000082-68-8 000050-55-5 000108-46-3 000480-54-6 000081-88-9 000989-38-8 013292-46-1 026308-28-1 122320-73-4

Pyrido[3,4-c]psoralen Pyrimethamine Quercetin para-Quinone Quintozene (Pentachloronitrobenzene) Reserpine Resorcinol Retrorsine Rhodamine B Rhodamine 6G Rifampicin Ripazepam Rosiglitazone

3 3 3 3 3 3 3 3 3 3 3 3 3

40, Sup 7 13, Sup 7 73 15, Sup 7, 71 5, Sup 7 24, Sup 7 15, Sup 7, 71 10, Sup 7 16, Sup 7 16, Sup 7 24, Sup 7 66 108

1987 1987 1999 1999 1987 1987 1999 1987 1987 1987 1987 1996 2016

000051-02-5 000122-42-9 000627-12-3 000115-07-1 087625-62-5

Group 0B

31

Volume

Year1

CAS No


Agent

Group 0B

023537-16-8 Rugulosin Rock (stone) wool 008047-67-4 Saccharated iron oxide 000081-07-2 Saccharin and its salts (NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data) 000085-83-6 Scarlet Red Schistosoma mansoni (infection with) 007782-49-2 Selenium and selenium compounds 000563-41-7 Semicarbazide hydrochloride 000480-81-9 Seneciphylline 002318-18-5 Senkirkine 015501-74-3 Sepiolite 000138-59-0 Shikimic acid 007631-86-9 Silica, amorphous Silicone breast implants 000122-34-9 Simazine 308068-56-6 Single-walled carbon nanotubes (see Carbon nanotubes, single-walled) Slag wool 007758-19-2 Sodium chlorite 000148-18-5 Sodium diethyldithiocarbamate 000052-01-7 Spironolactone 009003-54-7 Styrene-acrylonitrile copolymers 009003-55-8 Styrene-butadiene copolymers 000108-30-5 Succinic anhydride 000842-07-9 Sudan I 003118-97-6 Sudan II 000085-86-9 Sudan III 006416-57-5 Sudan Brown RR 006368-72-5 Sudan Red 7B 000127-69-5 Sulfafurazole (Sulfisoxazole) 000057-68-1 Sulfamethazine (NB: Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data) 000723-46-6 Sulfamethoxazole Sulfites 007446-09-5 Sulfur dioxide 002783-94-0 Sunset Yellow FCF

32

Volume

Year1

3 3 3 3

40, Sup 7 43, 81 2, Sup 7 73

1987 2002 1987 1999

3 3 3 3 3 3 3 3 3 3 3

8, Sup 7 61 9, Sup 7 12, Sup 7 10, Sup 7 31, Sup 7 68 40, Sup 7 68 74 73

1987 1994 1987 1987 1987 1987 1997 1987 1997 1999 1999

3 3 3 3 3 3 3 3 3 3 3 3 3 3

43, 81 52 12, Sup 7 79 19, Sup .7 19, Sup 7 15, Sup 7 8, Sup 7 8, Sup 7 8, Sup 7 8, Sup 7 8, Sup 7 24, Sup 7 79

2002 1991 1987 2001 1987 1987 1987 1987 1987 1987 1987 1987 1987 2001

3 3 3 3

79 54 54 8, Sup 7

2001 1992 1992 1987


022571-95-5 014807-96-6 001401-55-4 000846-50-4 008001-50-1 015721-02-5 000083-67-0 000058-55-9 000062-56-6 000137-26-8 000108-88-3 089778-26-7 021259-20-1 000052-68-6 000545-06-2 000071-55-6 000079-00-5 000102-71-6 001954-28-5 001582-09-8 090370-29-9 000137-17-7 000088-05-1 003902-71-4 000118-96-7 000217-59-4 000068-76-8 000545-55-1 000051-18-3 000115-96-8 038571-73-2 000057-39-6

Agent

Group 0B

Surgical implants (see Ceramic implants, Dental materials, Implanted foreign bodies, Organic polymeric materials, Orthopaedic implants, Silicone breast implants) SV40 polyomavirus Symphytine Talc not containing asbestos or asbestiform fibres Tannic acid and tannins Tea Temazepam Terpene polychlorinates (Strobane®) 2,2',5,5'-Tetrachlorobenzidine Tetrakis(hydroxymethyl)phosphonium salts Theobromine Theophylline Thiourea Thiram Toluene Toremifene T2-Trichothecene Trichlorfon Trichloroacetonitrile 1,1,1-Trichloroethane 1,1,2-Trichloroethane Triethanolamine Triethylene glycol diglycidyl ether Trifluralin 4,4',6-Trimethylangelicin plus ultraviolet A radiation 2,4,5-Trimethylaniline 2,4,6-Trimethylaniline 4,5',8-Trimethylpsoralen 2,4,6-Trinitrotoluene Triphenylene Tris(aziridinyl)-para-benzoquinone (Triaziquone) Tris(1-aziridinyl)phosphine oxide 2,4,6-Tris(1-aziridinyl)-s-triazine Tris(2-chloroethyl) phosphate 1,2,3-Tris(chloromethoxy)propane Tris(2-methyl-1-aziridinyl)phosphine oxide

33

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

Volume

104 31, Sup 7 42, Sup 7, 93 10, Sup 7 51 66 5, Sup 7 27, Sup 7 48, 71 51 51 79 53 47, 71 66 31, Sup 7 30, Sup 7 52, 71 20, Sup 7, 71 52, 71 77 11, Sup 7, 71 53 Sup 7 27, Sup 7 27, Sup 7 40, Sup 7 65 92 9, Sup 7 9, Sup 7 9, Sup 7 48, 71 15, Sup 7, 71 9, Sup 7

Year1

2014 1987 2010 1987 1991 1996 1987 1987 1999 1991 1991 2001 1991 1999 1996 1987 1987 1999 1999 1999 2000 1999 1991 1987 1987 1987 1987 1996 2010 1987 1987 1987 1999 1999 1987


000128-66-5 000143-67-9 002068-78-2 009003-22-9

Vat Yellow 4 Vinblastine sulfate Vincristine sulfate Vinyl chloride-vinyl acetate copolymers

3 3 3 3

48 26, Sup 7 26, Sup 7 19, Sup 7

1990 1987 1987 1987

009011-06-7 000075-38-7 000088-12-0 025013-15-4 012001-79-5 013983-17-0 001330-20-7 000095-68-1 000095-78-3 000085-84-7 000131-79-3 000315-18-4 001318-02-1

Vinylidene chloride-vinyl chloride copolymers Vinylidene fluoride N-Vinyl-2-pyrrolidone Vinyl toluene Vitamin K substances Wollastonite Xylenes 2,4-Xylidine 2,5-Xylidine Yellow AB Yellow OB Zectran Zeolites other than erionite (clinoptilolite, phillipsite,mordenite, non-fibrous Japanese zeolite, synthetic zeolites) Zineb Ziram Caprolactam Acetaminophen (see Paracetamol) Aldrin (see Dieldrin, and aldrin metabolized to dieldrin) Alpha particles (see Radionuclides) Attapulgite (see Palygorskite) Beta particles (see Radionuclides) N,N-Bis(2-chloroethyl)-2-naphthylamine (see Chlornaphazine) Bis(2-ethylhexyl) phthalate (see Di(2-ethylhexyl) phthalate) Boot and shoe manufacture and repair (see Leather dust, Benzene) 1,4-Butanediol dimethanesulfonate (see Busulfan) Chimney sweeping (see Soot) 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (see Methyl-CCNU) Chloromethyl methyl ether (see Bis(chloromethyl)ether; chloromethyl methyl ether)

3 3 3 3 3 3 3 3 3 3 3 3 3

19, Sup 7 39, Sup 7, 71 19, Sup 7, 71 60 76 68 47, 71 16, Sup 7 16, Sup 7 8, Sup 7 8, Sup 7 12, Sup 7 68

1987 1999 1999 1994 2000 1997 1999 1987 1987 1987 1987 1987 1997

3 3 4

12, Sup 7 53 39, Sup 7, 71

1987 1991 1999

25, Sup 7

1987

92

2010

012122-67-7 000137-30-4 000105-60-2 000103-90-2 000309-00-2 012174-11-7 000494-03-1 000117-81-7

000055-98-1 013909-09-6 000107-30-2

Group 0B

34

Volume

Year1

CAS No


Agent

Group 0B

Volume

Year1

Chlorophenols (see Polychlorophenols) 001937-37-7 CI Direct Black 38 (see Benzidine, dyes metabolized to) 002602-46-2 CI Direct Blue 6 (see Benzidine, dyes metabolized to) 016071-86-6 CI Direct Brown 95 (see Benzidine, dyes metabolized to) 008007-45-2 Coal tars (see Coal-tar distillation) Continuous glass filament (see Glass filament) 001464-53-5 1,2:3,4-Diepoxybutane (see Monographs on 1,3Butadiene) 000060-57-1 Dieldrin (see Dieldrin, and aldrin metabolized to dieldrin) Diesel engine exhaust (see Engine exhaust, diesel) Dyes metabolized to benzidine (see Benzidine, dyes metabolized to) Foreign bodies (see Surgical implants and other foreign bodies) Furniture and cabinet making (see Wood dust) 001303-00-0 Gallium arsenide (see Arsenic and inorganic arsenic compounds) Gamma-Radiation (see X- and Gamma-Radiation) Gasoline engine exhaust (see Engine exhaust, gasoline) High-temperature frying (see Frying) Hot mate (see Very hot beverages) Household combustion of biomass fuel (see Biomass fuel, indoor emissions from household combustion of) Household combustion of coal (see Coal, indoor emissions from household combustion) Human herpesvirus type 4 (see Epstein-Barr virus) Human herpesvirus type 8 (see Kaposi sarcoma herpesvirus) Involuntary smoking (see Tobacco smoke, second-hand) 010043-66-0 Iodine-131 (see Radioiodines) 000505-60-2 Mustard gas (see Sulfur mustard) 000055-98-1 Myleran (see Busulfan) Nickel refining (see Nickel compounds) Oestrogen (see Estrogen) Oral contraceptives, combined estrogen-progestogen (see Estrogen-progestogen oral contraceptives) 000523-44-4 Orange I (see CI Acid Orange 20) 001936-15-8 Orange G (see CI Orange G) Paving and roofing with coal-tar pitch (see Coal-tar pitch)

35

35, Sup 7

1987

11, Sup 7

1987

25, Sup 7 86, 100C

1987 2012

11

1976

92

2010


Agent

Group 0B

053973-98-1 Poligeenan (see Carrageenan, degraded) 007664-93-9 Strong-inorganic-acid mists containing sulfuric acid (see Acid mists) 010098-97-2 Strontium-90 (see Fission products) Sunlamps and sunbeds (see Ultraviolet-emitting tanning devices) 014807-96-6 Talc containing asbestiform fibres (see Asbestos) Toxins derived from certain Fusarium species (see Fusarium) 012070-12-1 Tungsten carbide with cobalt metal (see Cobalt metal 007440-48-4 with tungsten carbide) Urethane (see Ethyl carbamate) Wood smoke (see Biomass fuel, indoor emissions from household combustion) 1 2

Year of publication in print; if published in electronic format only, this is stated as “online” Includes radiofrequency electromagnetic fields from wireless phones

Last update: 23 October 2017

36

Volume

42, Sup 7

Year1

1987